FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1899469043> ?p ?o ?g. }

• W1899469043 endingPage "1016" @default.
• W1899469043 startingPage "1009" @default.
• W1899469043 abstract "The mouse alpha-lactalbumin gene has been replaced with the human gene by two consecutive rounds of gene targeting in hypoxanthine phosphoribosyltransferase (HPRT)-deficient feeder-independent murine embryonic stem (ES) cells. One mouse alpha-lactalbumin allele was first replaced by an HPRT minigene which was in turn replaced by human alpha-lactalbumin. The end result is a clean exchange of defined DNA fragments with no other DNA remaining at the target locus. Targeted ES cells at each stage remained capable of contributing efficiently to the germ line of chimeric animals. Double replacement using HPRT-deficient ES cells and the HPRT selection system is therefore a powerful and flexible method of targeting specific alterations to animal genes. A typical strategy for future use would be to generate a null mutation which could then be used to produce multiple second-step alterations at the same locus." @default.
• W1899469043 created "2016-06-24" @default.
• W1899469043 creator A5013468905 @default.
• W1899469043 creator A5026456188 @default.
• W1899469043 creator A5033688133 @default.
• W1899469043 creator A5062081714 @default.
• W1899469043 creator A5087530760 @default.
• W1899469043 creator A5087681454 @default.
• W1899469043 date "1994-02-01" @default.
• W1899469043 modified "2023-10-07" @default.
• W1899469043 title "Use of double-replacement gene targeting to replace the murine alpha-lactalbumin gene with its human counterpart in embryonic stem cells and mice." @default.
• W1899469043 cites W107172435 @default.
• W1899469043 cites W1484163259 @default.
• W1899469043 cites W1802649525 @default.
• W1899469043 cites W1820036906 @default.
• W1899469043 cites W1850435450 @default.
• W1899469043 cites W1904279590 @default.
• W1899469043 cites W1951800697 @default.
• W1899469043 cites W1966595105 @default.
• W1899469043 cites W1972260583 @default.
• W1899469043 cites W1975297300 @default.
• W1899469043 cites W1980739617 @default.
• W1899469043 cites W1983237714 @default.
• W1899469043 cites W1986582631 @default.
• W1899469043 cites W1989194294 @default.
• W1899469043 cites W1989385179 @default.
• W1899469043 cites W1991502013 @default.
• W1899469043 cites W1994901592 @default.
• W1899469043 cites W2000170431 @default.
• W1899469043 cites W2012134426 @default.
• W1899469043 cites W2047853337 @default.
• W1899469043 cites W2053200644 @default.
• W1899469043 cites W2062210778 @default.
• W1899469043 cites W2072735811 @default.
• W1899469043 cites W2074244754 @default.
• W1899469043 cites W2084963186 @default.
• W1899469043 cites W2091882935 @default.
• W1899469043 cites W2096859263 @default.
• W1899469043 cites W2101710059 @default.
• W1899469043 cites W2107238263 @default.
• W1899469043 cites W2108056897 @default.
• W1899469043 cites W2110881937 @default.
• W1899469043 cites W2118529037 @default.
• W1899469043 cites W2163391143 @default.
• W1899469043 cites W2168504426 @default.
• W1899469043 cites W2180457952 @default.
• W1899469043 cites W2180906670 @default.
• W1899469043 doi "https://doi.org/10.1128/mcb.14.2.1009" @default.
• W1899469043 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/358456" @default.
• W1899469043 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8289781" @default.
• W1899469043 hasPublicationYear "1994" @default.
• W1899469043 type Work @default.
• W1899469043 sameAs 1899469043 @default.
• W1899469043 citedByCount "95" @default.
• W1899469043 countsByYear W18994690432013 @default.
• W1899469043 countsByYear W18994690432015 @default.
• W1899469043 countsByYear W18994690432016 @default.
• W1899469043 countsByYear W18994690432019 @default.
• W1899469043 crossrefType "journal-article" @default.
• W1899469043 hasAuthorship W1899469043A5013468905 @default.
• W1899469043 hasAuthorship W1899469043A5026456188 @default.
• W1899469043 hasAuthorship W1899469043A5033688133 @default.
• W1899469043 hasAuthorship W1899469043A5062081714 @default.
• W1899469043 hasAuthorship W1899469043A5087530760 @default.
• W1899469043 hasAuthorship W1899469043A5087681454 @default.
• W1899469043 hasBestOaLocation W18994690432 @default.
• W1899469043 hasConcept C104317684 @default.
• W1899469043 hasConcept C111829913 @default.
• W1899469043 hasConcept C143065580 @default.
• W1899469043 hasConcept C145103041 @default.
• W1899469043 hasConcept C153911025 @default.
• W1899469043 hasConcept C166342232 @default.
• W1899469043 hasConcept C194583182 @default.
• W1899469043 hasConcept C2796436 @default.
• W1899469043 hasConcept C28328180 @default.
• W1899469043 hasConcept C2909697302 @default.
• W1899469043 hasConcept C30278631 @default.
• W1899469043 hasConcept C36823959 @default.
• W1899469043 hasConcept C54355233 @default.
• W1899469043 hasConcept C57708383 @default.
• W1899469043 hasConcept C78179603 @default.
• W1899469043 hasConcept C84597430 @default.
• W1899469043 hasConcept C86803240 @default.
• W1899469043 hasConceptScore W1899469043C104317684 @default.
• W1899469043 hasConceptScore W1899469043C111829913 @default.
• W1899469043 hasConceptScore W1899469043C143065580 @default.
• W1899469043 hasConceptScore W1899469043C145103041 @default.
• W1899469043 hasConceptScore W1899469043C153911025 @default.
• W1899469043 hasConceptScore W1899469043C166342232 @default.
• W1899469043 hasConceptScore W1899469043C194583182 @default.
• W1899469043 hasConceptScore W1899469043C2796436 @default.
• W1899469043 hasConceptScore W1899469043C28328180 @default.
• W1899469043 hasConceptScore W1899469043C2909697302 @default.
• W1899469043 hasConceptScore W1899469043C30278631 @default.
• W1899469043 hasConceptScore W1899469043C36823959 @default.
• W1899469043 hasConceptScore W1899469043C54355233 @default.
• W1899469043 hasConceptScore W1899469043C57708383 @default.
• W1899469043 hasConceptScore W1899469043C78179603 @default.

• next