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- W18996837 abstract "The aim of this study is to clarify the relationship between serum 3-O-methyldopa (3-OMD) and the clinical effects of entacapone. The 3-OMD and maximum serum concentration (Cmax) of levodopa were measured in 21 Parkinson's Disease patients who took 100 mg levodopa / dopa decarboxylase inhibitor. After the administration of entacapone, the 3-OMD concentration and percentage of on time during waking hours (% of on time) were studied for 8 weeks. The 3-OMD concentration was reduced by 34%, and the increase in % of on time was 28% at the 8th week compared with baseline. We defined the COMT-index as [baseline 3-OMD concentration] / [levodopa Cmax when 100 mg levodopa was administered alone]. The COMT-index was significantly correlated with the increase in % of on time at the 8th week. In conclusion, the measurement of baseline 3-OMD and levodopa pharmacokinetics is useful for predicting the clinical effects of entacapone." @default.
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- W18996837 date "2011-09-01" @default.
- W18996837 modified "2023-10-18" @default.
- W18996837 title "Relationship between 3-O-methyldopa and the clinical effects of entacapone in advanced Parkinson's disease." @default.
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