FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1899689470> ?p ?o ?g. }

• W1899689470 endingPage "3402" @default.
• W1899689470 startingPage "3397" @default.
• W1899689470 abstract "ABSTRACT Adherence of parasite-infected erythrocytes (IEs) to the microvascular endothelium of various organs, a process known as sequestration, is a feature of Plasmodium falciparum malaria. This event is mediated by specific adhesive interactions between parasite proteins, expressed on the surface of IEs, and host molecules. P. falciparum IEs can bind to purified chondroitin sulfate A (CS-A), to the proteoglycan thrombomodulin through CS-A side chains, and to CS-A present on the surface of brain and lung endothelial cells and placental syncytiotrophoblasts. In order to identify structural characteristics of CS-A important for binding, oligosaccharide fragments ranging in size from 2 to 20 monosaccharide units were isolated from CS-A and CS-C, following controlled chondroitin lyase digestion, and used as competitive inhibitors of IE binding to immobilized ligands. Inhibition of binding to CS-A was highly dependent on molecular size: a CS-A tetradecasaccharide fraction was the minimum length able to almost completely inhibit binding. The effect was dose dependent and similar to that of the parent polysaccharide, and the same degree of inhibition was not found with the CS-C oligosaccharides. There was no effect on binding of IEs to other ligands, e.g., CD36 and intercellular adhesion molecule 1. Hexadeca- and octadecasaccharide fractions of CS-A were required for maximum inhibition of binding to thrombomodulin. Analyses of oligosaccharide fractions and polysaccharides by electrospray mass spectrometry and high-performance liquid chromatography suggest that the differences between the activities of CS-A and CS-C oligosaccharides can be attributed to differences in sulfate content and sulfation pattern and that iduronic acid is not involved in IE binding." @default.
• W1899689470 created "2016-06-24" @default.
• W1899689470 creator A5039234260 @default.
• W1899689470 creator A5049265849 @default.
• W1899689470 creator A5077385105 @default.
• W1899689470 creator A5077431608 @default.
• W1899689470 creator A5078488695 @default.
• W1899689470 date "1998-07-01" @default.
• W1899689470 modified "2023-10-16" @default.
• W1899689470 title "Inhibition of Binding of Malaria-Infected Erythrocytes by a Tetradecasaccharide Fraction from Chondroitin Sulfate A" @default.
• W1899689470 cites W1536511766 @default.
• W1899689470 cites W1543482838 @default.
• W1899689470 cites W1593495424 @default.
• W1899689470 cites W1601945803 @default.
• W1899689470 cites W167062134 @default.
• W1899689470 cites W1750130041 @default.
• W1899689470 cites W1855353753 @default.
• W1899689470 cites W191901781 @default.
• W1899689470 cites W1938411842 @default.
• W1899689470 cites W1967192407 @default.
• W1899689470 cites W1983320016 @default.
• W1899689470 cites W1984840918 @default.
• W1899689470 cites W1998855105 @default.
• W1899689470 cites W1999249942 @default.
• W1899689470 cites W2002655185 @default.
• W1899689470 cites W2013899184 @default.
• W1899689470 cites W2020251171 @default.
• W1899689470 cites W2021874649 @default.
• W1899689470 cites W2028526808 @default.
• W1899689470 cites W2030994801 @default.
• W1899689470 cites W2033736186 @default.
• W1899689470 cites W2039266863 @default.
• W1899689470 cites W2040237189 @default.
• W1899689470 cites W2044708838 @default.
• W1899689470 cites W2059405663 @default.
• W1899689470 cites W2059917880 @default.
• W1899689470 cites W2070308532 @default.
• W1899689470 cites W2074535583 @default.
• W1899689470 cites W2076000327 @default.
• W1899689470 cites W2076481966 @default.
• W1899689470 cites W2083541967 @default.
• W1899689470 cites W2083788953 @default.
• W1899689470 cites W2085541452 @default.
• W1899689470 cites W2094649888 @default.
• W1899689470 cites W2095622544 @default.
• W1899689470 cites W2119678833 @default.
• W1899689470 cites W2132140005 @default.
• W1899689470 cites W2149443398 @default.
• W1899689470 cites W2155421201 @default.
• W1899689470 cites W2395791699 @default.
• W1899689470 cites W2409658973 @default.
• W1899689470 cites W2413393961 @default.
• W1899689470 cites W4211103546 @default.
• W1899689470 cites W4247666569 @default.
• W1899689470 cites W55402024 @default.
• W1899689470 doi "https://doi.org/10.1128/iai.66.7.3397-3402.1998" @default.
• W1899689470 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/108358" @default.
• W1899689470 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9632611" @default.
• W1899689470 hasPublicationYear "1998" @default.
• W1899689470 type Work @default.
• W1899689470 sameAs 1899689470 @default.
• W1899689470 citedByCount "52" @default.
• W1899689470 countsByYear W18996894702012 @default.
• W1899689470 countsByYear W18996894702014 @default.
• W1899689470 countsByYear W18996894702016 @default.
• W1899689470 countsByYear W18996894702018 @default.
• W1899689470 countsByYear W18996894702019 @default.
• W1899689470 crossrefType "journal-article" @default.
• W1899689470 hasAuthorship W1899689470A5039234260 @default.
• W1899689470 hasAuthorship W1899689470A5049265849 @default.
• W1899689470 hasAuthorship W1899689470A5077385105 @default.
• W1899689470 hasAuthorship W1899689470A5077431608 @default.
• W1899689470 hasAuthorship W1899689470A5078488695 @default.
• W1899689470 hasBestOaLocation W18996894701 @default.
• W1899689470 hasConcept C100817775 @default.
• W1899689470 hasConcept C107824862 @default.
• W1899689470 hasConcept C153074725 @default.
• W1899689470 hasConcept C201267052 @default.
• W1899689470 hasConcept C203014093 @default.
• W1899689470 hasConcept C2775895372 @default.
• W1899689470 hasConcept C2775909754 @default.
• W1899689470 hasConcept C2776735749 @default.
• W1899689470 hasConcept C2777292125 @default.
• W1899689470 hasConcept C2777557582 @default.
• W1899689470 hasConcept C2777726330 @default.
• W1899689470 hasConcept C2778041096 @default.
• W1899689470 hasConcept C2778048844 @default.
• W1899689470 hasConcept C2778371730 @default.
• W1899689470 hasConcept C2779553658 @default.
• W1899689470 hasConcept C2779650520 @default.
• W1899689470 hasConcept C55493867 @default.
• W1899689470 hasConcept C86803240 @default.
• W1899689470 hasConcept C89560881 @default.
• W1899689470 hasConceptScore W1899689470C100817775 @default.
• W1899689470 hasConceptScore W1899689470C107824862 @default.
• W1899689470 hasConceptScore W1899689470C153074725 @default.
• W1899689470 hasConceptScore W1899689470C201267052 @default.
• W1899689470 hasConceptScore W1899689470C203014093 @default.

• next