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• W1899691332 endingPage "11959" @default.
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• W1899691332 abstract "Survivors of preterm birth are at high risk of pervasive cognitive and learning impairments, suggesting disrupted early brain development. The limits of viability for preterm birth encompass the third trimester of pregnancy, a precritical period of activity-dependent development characterized by the onset of spontaneous and evoked patterned electrical activity that drives neuronal maturation and formation of cortical circuits. Reduced background activity on electroencephalogram (EEG) is a sensitive marker of brain injury in human preterm infants that predicts poor neurodevelopmental outcome. We studied a rodent model of very early hypoxic-ischemic brain injury to investigate effects of injury on both general background and specific patterns of cortical activity measured with EEG. EEG background activity is depressed transiently after moderate hypoxia-ischemia with associated loss of spindle bursts. Depressed activity, in turn, is associated with delayed expression of glutamate receptor subunits and transporters. Cortical pyramidal neurons show reduced dendrite development and spine formation. Complementing previous observations in this model of impaired visual cortical plasticity, we find reduced somatosensory whisker barrel plasticity. Finally, EEG recordings from human premature newborns with brain injury demonstrate similar depressed background activity and loss of bursts in the spindle frequency band. Together, these findings suggest that abnormal development after early brain injury may result in part from disruption of specific forms of brain activity necessary for activity-dependent circuit development.Preterm birth and term birth asphyxia result in brain injury from inadequate oxygen delivery and constitute a major and growing worldwide health problem. Poor outcomes are noted in a majority of very premature (<25 weeks gestation) newborns, resulting in death or life-long morbidity with motor, sensory, learning, behavioral, and language disabilities that limit academic achievement and well-being. Limited progress has been made to develop therapies that improve neurologic outcomes. The overall objective of this study is to understand the effect of early brain injury on activity-dependent brain development and cortical plasticity to develop new treatments that will optimize repair and recovery after brain injury." @default.
• W1899691332 created "2016-06-24" @default.
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• W1899691332 date "2015-08-26" @default.
• W1899691332 modified "2023-10-15" @default.
• W1899691332 title "Reduced Cortical Activity Impairs Development and Plasticity after Neonatal Hypoxia Ischemia" @default.
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• W1899691332 cites W1880079596 @default.
• W1899691332 cites W1930405521 @default.
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• W1899691332 cites W1972797480 @default.
• W1899691332 cites W1975797278 @default.
• W1899691332 cites W1979640889 @default.
• W1899691332 cites W1981360765 @default.
• W1899691332 cites W1981799940 @default.
• W1899691332 cites W1982752299 @default.
• W1899691332 cites W1985111805 @default.
• W1899691332 cites W1986408320 @default.
• W1899691332 cites W1990323131 @default.
• W1899691332 cites W1993628295 @default.
• W1899691332 cites W2001116239 @default.
• W1899691332 cites W2007644749 @default.
• W1899691332 cites W2013377646 @default.
• W1899691332 cites W2017265687 @default.
• W1899691332 cites W2019203795 @default.
• W1899691332 cites W2029219843 @default.
• W1899691332 cites W2035409446 @default.
• W1899691332 cites W2040666378 @default.
• W1899691332 cites W2045915611 @default.
• W1899691332 cites W2046545720 @default.
• W1899691332 cites W2047555285 @default.
• W1899691332 cites W2049021816 @default.
• W1899691332 cites W2050215536 @default.
• W1899691332 cites W2050247727 @default.
• W1899691332 cites W2052437034 @default.
• W1899691332 cites W2052449009 @default.
• W1899691332 cites W2057098469 @default.
• W1899691332 cites W2059743066 @default.
• W1899691332 cites W2064896583 @default.
• W1899691332 cites W2068247428 @default.
• W1899691332 cites W2075400177 @default.
• W1899691332 cites W2075677999 @default.
• W1899691332 cites W2076605578 @default.
• W1899691332 cites W2079141380 @default.
• W1899691332 cites W2079801737 @default.
• W1899691332 cites W2081918193 @default.
• W1899691332 cites W2082333529 @default.
• W1899691332 cites W2083541352 @default.
• W1899691332 cites W2086416919 @default.
• W1899691332 cites W2087774055 @default.
• W1899691332 cites W2094442107 @default.
• W1899691332 cites W2097604510 @default.
• W1899691332 cites W2097760882 @default.
• W1899691332 cites W2109132762 @default.
• W1899691332 cites W2111447973 @default.
• W1899691332 cites W2112140599 @default.
• W1899691332 cites W2112166106 @default.
• W1899691332 cites W2113996138 @default.
• W1899691332 cites W2114603675 @default.
• W1899691332 cites W2118214897 @default.
• W1899691332 cites W2119119716 @default.
• W1899691332 cites W2119137351 @default.
• W1899691332 cites W2120787848 @default.
• W1899691332 cites W2127068730 @default.
• W1899691332 cites W2128966898 @default.
• W1899691332 cites W2130023909 @default.
• W1899691332 cites W2130249957 @default.
• W1899691332 cites W2133369864 @default.
• W1899691332 cites W2139403906 @default.
• W1899691332 cites W2140214978 @default.
• W1899691332 cites W2145036203 @default.
• W1899691332 cites W2153065561 @default.
• W1899691332 cites W2156252138 @default.
• W1899691332 cites W2159941510 @default.
• W1899691332 cites W2167279371 @default.
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• W1899691332 doi "https://doi.org/10.1523/jneurosci.2682-14.2015" @default.
• W1899691332 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4549405" @default.
• W1899691332 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26311776" @default.
• W1899691332 hasPublicationYear "2015" @default.
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