FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1899693826> ?p ?o ?g. }

• W1899693826 endingPage "1009" @default.
• W1899693826 startingPage "998" @default.
• W1899693826 abstract "Disease overview : Multiple myeloma accounts for approximately 10% of hematologic malignancies. Diagnosis : The diagnosis requires 10% or more clonal plasma cells on bone marrow examination or a biopsy proven plasmacytoma plus evidence of associated end‐organ damage. If end‐organ damage is not present, the presence of 60% or more clonal plasma cells in the marrow is also considered as myeloma. Risk stratification : In the absence of concurrent trisomies, patients with 17p deletion, t(14;16), and t(14;20) are considered to have high‐risk myeloma. Patients with t(4;14) translocation are considered intermediate‐risk. All others are considered as standard‐risk. Risk‐adapted intial therapy : Standard‐risk patients can be treated with lenalidomide plus low‐dose dexamethasone (Rd), or a bortezomib‐containing triplet such as bortezomib, cyclophosphamide, dexamethasone (VCD). Intermediate‐risk and high‐risk patients require a bortezomib‐based triplet regimen. In eligible patients, initial therapy is given for approximately 4 months followed by autologous stem cell transplantation (ASCT). Standard risk patients can opt for delayed ASCT if stem cells can be cryopreserved. In patients who are not candidates for transplant, initial therapy is given for approximately 12 to 18 months. Maintenance therapy : After initial therapy, lenalidomide maintenance is considered for standard risk patients who are not in very good partial response or better, while maintenance with a bortezomib‐based regimen should be considered in patients with intermediate or high risk myeloma. Management of refractory disease : Patients with indolent relapse can be treated first with 2‐drug or 3‐drug combinations. Patients with more aggressive relapse often require therapy with a combination of multiple active agents. Am. J. Hematol. 89:998–1009, 2014. © 2014 Wiley Periodicals, Inc." @default.
• W1899693826 created "2016-06-24" @default.
• W1899693826 creator A5066940168 @default.
• W1899693826 date "2014-09-16" @default.
• W1899693826 modified "2023-10-15" @default.
• W1899693826 title "Multiple myeloma: 2014 Update on diagnosis, risk-stratification, and management" @default.
• W1899693826 cites W137122611 @default.
• W1899693826 cites W1556628912 @default.
• W1899693826 cites W182568540 @default.
• W1899693826 cites W1964471413 @default.
• W1899693826 cites W1967276606 @default.
• W1899693826 cites W1968654086 @default.
• W1899693826 cites W1969648097 @default.
• W1899693826 cites W1973888964 @default.
• W1899693826 cites W1974983065 @default.
• W1899693826 cites W1982496733 @default.
• W1899693826 cites W1983706317 @default.
• W1899693826 cites W1986692982 @default.
• W1899693826 cites W1988092780 @default.
• W1899693826 cites W1988265934 @default.
• W1899693826 cites W1992538067 @default.
• W1899693826 cites W1997952190 @default.
• W1899693826 cites W2001151538 @default.
• W1899693826 cites W2003734726 @default.
• W1899693826 cites W2006382315 @default.
• W1899693826 cites W2008886056 @default.
• W1899693826 cites W2011871138 @default.
• W1899693826 cites W2013370486 @default.
• W1899693826 cites W2015003025 @default.
• W1899693826 cites W2015880063 @default.
• W1899693826 cites W2015934295 @default.
• W1899693826 cites W2020778579 @default.
• W1899693826 cites W2021954218 @default.
• W1899693826 cites W2023501070 @default.
• W1899693826 cites W2025656486 @default.
• W1899693826 cites W2026895719 @default.
• W1899693826 cites W2027698431 @default.
• W1899693826 cites W2028399237 @default.
• W1899693826 cites W2028611771 @default.
• W1899693826 cites W2030764092 @default.
• W1899693826 cites W2030885435 @default.
• W1899693826 cites W2031157863 @default.
• W1899693826 cites W2036985459 @default.
• W1899693826 cites W2038908179 @default.
• W1899693826 cites W2039838780 @default.
• W1899693826 cites W2040889135 @default.
• W1899693826 cites W2040925557 @default.
• W1899693826 cites W2043396394 @default.
• W1899693826 cites W2044436186 @default.
• W1899693826 cites W2046344454 @default.
• W1899693826 cites W2047300367 @default.
• W1899693826 cites W2055338149 @default.
• W1899693826 cites W2056199034 @default.
• W1899693826 cites W2057660602 @default.
• W1899693826 cites W2060496777 @default.
• W1899693826 cites W2060630093 @default.
• W1899693826 cites W2060929578 @default.
• W1899693826 cites W2066668506 @default.
• W1899693826 cites W2066800926 @default.
• W1899693826 cites W2067410031 @default.
• W1899693826 cites W2068698136 @default.
• W1899693826 cites W2071006295 @default.
• W1899693826 cites W2071434932 @default.
• W1899693826 cites W2071541868 @default.
• W1899693826 cites W2078752778 @default.
• W1899693826 cites W2083181071 @default.
• W1899693826 cites W2083365324 @default.
• W1899693826 cites W2083814475 @default.
• W1899693826 cites W2085092835 @default.
• W1899693826 cites W2086990334 @default.
• W1899693826 cites W2088081193 @default.
• W1899693826 cites W2089311432 @default.
• W1899693826 cites W2090310344 @default.
• W1899693826 cites W2091773528 @default.
• W1899693826 cites W2093757149 @default.
• W1899693826 cites W2095109341 @default.
• W1899693826 cites W2095255742 @default.
• W1899693826 cites W2096207943 @default.
• W1899693826 cites W2097331346 @default.
• W1899693826 cites W2101576302 @default.
• W1899693826 cites W2102591890 @default.
• W1899693826 cites W2103289287 @default.
• W1899693826 cites W2110466835 @default.
• W1899693826 cites W2113020324 @default.
• W1899693826 cites W2115760271 @default.
• W1899693826 cites W2117172636 @default.
• W1899693826 cites W2117582823 @default.
• W1899693826 cites W2120474651 @default.
• W1899693826 cites W2120780398 @default.
• W1899693826 cites W2122038117 @default.
• W1899693826 cites W2124240218 @default.
• W1899693826 cites W2124560610 @default.
• W1899693826 cites W2125721471 @default.
• W1899693826 cites W2125765642 @default.
• W1899693826 cites W2126894260 @default.
• W1899693826 cites W2127760782 @default.
• W1899693826 cites W2128084036 @default.
• W1899693826 cites W2128880706 @default.

• next