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- W1899700862 endingPage "2026" @default.
- W1899700862 startingPage "2019" @default.
- W1899700862 abstract "Programmed necrosis mediated by receptor interacting protein kinase (RIP)3 (also called RIPK3) has emerged as an alternate death pathway triggered by TNF family death receptors, pathogen sensors, IFNRs, Ag-specific TCR activation, and genotoxic stress. Necrosis leads to cell leakage and acts as a trap door, eliminating cells that cannot die by apoptosis because of the elaboration of pathogen-encoded caspase inhibitors. Necrotic signaling requires RIP3 binding to one of three partners-RIP1, DAI, or TRIF-via a common RIP homotypic interaction motif. Once activated, RIP3 kinase targets the pseudokinase mixed lineage kinase domain-like to drive cell lysis. Although necrotic and apoptotic death can enhance T cell cross-priming during infection, mice that lack these extrinsic programmed cell death pathways are able to produce Ag-specific T cells and control viral infection. The entwined relationship of apoptosis and necrosis evolved in response to pathogen-encoded suppressors to support host defense and contribute to inflammation." @default.
- W1899700862 created "2016-06-24" @default.
- W1899700862 creator A5017200212 @default.
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- W1899700862 creator A5035976818 @default.
- W1899700862 creator A5055638395 @default.
- W1899700862 creator A5076195846 @default.
- W1899700862 date "2014-02-21" @default.
- W1899700862 modified "2023-10-12" @default.
- W1899700862 title "True Grit: Programmed Necrosis in Antiviral Host Defense, Inflammation, and Immunogenicity" @default.
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