Matches in SemOpenAlex for { <https://semopenalex.org/work/W1899719674> ?p ?o ?g. }
- W1899719674 endingPage "1893" @default.
- W1899719674 startingPage "1883" @default.
- W1899719674 abstract "High-level resistance to antimicrobial drugs is a major factor in the pathogenesis of chronic Staphylococcus aureus biofilm-associated, medical device-related infections. Antimicrobial susceptibility analysis revealed that biofilms grown for ≤ 24 hours on biomaterials conditioned with human plasma under venous shear in iron-free cell culture medium were significantly more susceptible to antistaphylococcal antibiotics. Biofilms formed under these physiologically relevant conditions were regulated by SaeRS and dependent on coagulase-catalyzed conversion of fibrinogen into fibrin. In contrast, SarA-regulated biofilms formed on uncoated polystyrene in nutrient-rich bacteriological medium were mediated by the previously characterized biofilm factors poly-N-acetyl glucosamine, fibronectin-binding proteins, or autolytic activity and were antibiotic resistant. Coagulase-mediated biofilms exhibited increased antimicrobial resistance over time (>48 hours) but were always susceptible to dispersal by the fibrinolytic enzymes plasmin or nattokinase. Biofilms recovered from infected central venous catheters in a rat model of device-related infection were dispersed by nattokinase, supporting the important role of the biofilm phenotype and identifying a potentially new therapeutic approach with antimicrobials and fibrinolytic drugs, particularly during the early stages of device-related infection." @default.
- W1899719674 created "2016-06-24" @default.
- W1899719674 creator A5000144696 @default.
- W1899719674 creator A5019032222 @default.
- W1899719674 creator A5066232739 @default.
- W1899719674 creator A5086744844 @default.
- W1899719674 creator A5087289174 @default.
- W1899719674 date "2015-06-04" @default.
- W1899719674 modified "2023-10-10" @default.
- W1899719674 title "An Essential Role for Coagulase in<i>Staphylococcus aureus</i>Biofilm Development Reveals New Therapeutic Possibilities for Device-Related Infections" @default.
- W1899719674 cites W1506811449 @default.
- W1899719674 cites W1963912540 @default.
- W1899719674 cites W1969275616 @default.
- W1899719674 cites W1970022475 @default.
- W1899719674 cites W1973675012 @default.
- W1899719674 cites W1973836606 @default.
- W1899719674 cites W1991532243 @default.
- W1899719674 cites W1994852088 @default.
- W1899719674 cites W2001277616 @default.
- W1899719674 cites W2001326149 @default.
- W1899719674 cites W2003147562 @default.
- W1899719674 cites W2006333863 @default.
- W1899719674 cites W2016045705 @default.
- W1899719674 cites W2017292954 @default.
- W1899719674 cites W2029900219 @default.
- W1899719674 cites W2037982852 @default.
- W1899719674 cites W2038924596 @default.
- W1899719674 cites W2059444426 @default.
- W1899719674 cites W2061688904 @default.
- W1899719674 cites W2066767199 @default.
- W1899719674 cites W2068041880 @default.
- W1899719674 cites W2073828123 @default.
- W1899719674 cites W2098785211 @default.
- W1899719674 cites W2102360445 @default.
- W1899719674 cites W2106498488 @default.
- W1899719674 cites W2106538205 @default.
- W1899719674 cites W2112363064 @default.
- W1899719674 cites W2121897239 @default.
- W1899719674 cites W2123572535 @default.
- W1899719674 cites W2126420325 @default.
- W1899719674 cites W2127113854 @default.
- W1899719674 cites W2127498551 @default.
- W1899719674 cites W2127839426 @default.
- W1899719674 cites W2132145187 @default.
- W1899719674 cites W2134017075 @default.
- W1899719674 cites W2137010791 @default.
- W1899719674 cites W2149660414 @default.
- W1899719674 cites W2154661271 @default.
- W1899719674 cites W2155252498 @default.
- W1899719674 cites W2156126133 @default.
- W1899719674 cites W2157220975 @default.
- W1899719674 cites W2158033863 @default.
- W1899719674 cites W2163463398 @default.
- W1899719674 cites W2165139231 @default.
- W1899719674 cites W2166961382 @default.
- W1899719674 cites W2171414599 @default.
- W1899719674 cites W2172074295 @default.
- W1899719674 cites W2407136586 @default.
- W1899719674 cites W4242084189 @default.
- W1899719674 doi "https://doi.org/10.1093/infdis/jiv319" @default.
- W1899719674 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26044292" @default.
- W1899719674 hasPublicationYear "2015" @default.
- W1899719674 type Work @default.
- W1899719674 sameAs 1899719674 @default.
- W1899719674 citedByCount "84" @default.
- W1899719674 countsByYear W18997196742016 @default.
- W1899719674 countsByYear W18997196742017 @default.
- W1899719674 countsByYear W18997196742018 @default.
- W1899719674 countsByYear W18997196742019 @default.
- W1899719674 countsByYear W18997196742020 @default.
- W1899719674 countsByYear W18997196742021 @default.
- W1899719674 countsByYear W18997196742022 @default.
- W1899719674 countsByYear W18997196742023 @default.
- W1899719674 crossrefType "journal-article" @default.
- W1899719674 hasAuthorship W1899719674A5000144696 @default.
- W1899719674 hasAuthorship W1899719674A5019032222 @default.
- W1899719674 hasAuthorship W1899719674A5066232739 @default.
- W1899719674 hasAuthorship W1899719674A5086744844 @default.
- W1899719674 hasAuthorship W1899719674A5087289174 @default.
- W1899719674 hasBestOaLocation W18997196741 @default.
- W1899719674 hasConcept C181199279 @default.
- W1899719674 hasConcept C185592680 @default.
- W1899719674 hasConcept C2777334864 @default.
- W1899719674 hasConcept C2779288629 @default.
- W1899719674 hasConcept C2779489039 @default.
- W1899719674 hasConcept C2781071845 @default.
- W1899719674 hasConcept C4937899 @default.
- W1899719674 hasConcept C501593827 @default.
- W1899719674 hasConcept C523546767 @default.
- W1899719674 hasConcept C54355233 @default.
- W1899719674 hasConcept C55493867 @default.
- W1899719674 hasConcept C58123911 @default.
- W1899719674 hasConcept C8408860 @default.
- W1899719674 hasConcept C86803240 @default.
- W1899719674 hasConcept C89423630 @default.
- W1899719674 hasConcept C94665300 @default.
- W1899719674 hasConceptScore W1899719674C181199279 @default.
- W1899719674 hasConceptScore W1899719674C185592680 @default.