Matches in SemOpenAlex for { <https://semopenalex.org/work/W1899752912> ?p ?o ?g. }
- W1899752912 endingPage "904" @default.
- W1899752912 startingPage "895" @default.
- W1899752912 abstract "Changes in chemokine receptor expression are important in determining T cell migration and the subsequent immune response. To better understand the contribution of the chemokine system in immune senescence we determined the effect of aging on CD4(+) T cell chemokine receptor function using microarray, RNase protection assays, Western blot, and in vitro chemokine transmigration assays. Freshly isolated CD4(+) cells from aged (20-22 mo) mice were found to express a higher level of CCR1, 2, 4, 5, 6, and 8 and CXCR2-5, and a lower level of CCR7 and 9 than those from young (3-4 mo) animals. Caloric restriction partially or completely restored the aging effects on CCR1, 7, and 8 and CXCR2, 4, and 5. The aging-associated differences in chemokine receptor expression cannot be adequately explained by the age-associated shift in the naive/memory or Th1/Th2 profile. CD4(+) cells from aged animals have increased chemotactic response to stromal cell-derived factor-1 and macrophage-inflammatory protein-1alpha, suggesting that the observed chemokine receptor changes have important functional consequences. We propose that the aging-associated changes in T cell chemokine receptor expression may contribute to the different clinical outcome in T cell chemokine receptor-dependent diseases in the elderly." @default.
- W1899752912 created "2016-06-24" @default.
- W1899752912 creator A5007878481 @default.
- W1899752912 creator A5018473516 @default.
- W1899752912 creator A5040156444 @default.
- W1899752912 creator A5050876804 @default.
- W1899752912 creator A5051201397 @default.
- W1899752912 creator A5055777832 @default.
- W1899752912 creator A5084936917 @default.
- W1899752912 creator A5088877031 @default.
- W1899752912 date "2003-01-15" @default.
- W1899752912 modified "2023-10-03" @default.
- W1899752912 title "T Cell Chemokine Receptor Expression in Aging" @default.
- W1899752912 cites W1523694553 @default.
- W1899752912 cites W1527078822 @default.
- W1899752912 cites W1552567815 @default.
- W1899752912 cites W1594451450 @default.
- W1899752912 cites W1648671938 @default.
- W1899752912 cites W1806371085 @default.
- W1899752912 cites W1821778272 @default.
- W1899752912 cites W1881691580 @default.
- W1899752912 cites W1963984954 @default.
- W1899752912 cites W1965019797 @default.
- W1899752912 cites W1971222990 @default.
- W1899752912 cites W1973572963 @default.
- W1899752912 cites W1981480494 @default.
- W1899752912 cites W1981644527 @default.
- W1899752912 cites W1982854219 @default.
- W1899752912 cites W1983404910 @default.
- W1899752912 cites W1986420324 @default.
- W1899752912 cites W1986512614 @default.
- W1899752912 cites W1988367414 @default.
- W1899752912 cites W1989035987 @default.
- W1899752912 cites W1991233761 @default.
- W1899752912 cites W1991641555 @default.
- W1899752912 cites W1994343537 @default.
- W1899752912 cites W1999355913 @default.
- W1899752912 cites W2001044562 @default.
- W1899752912 cites W2003124067 @default.
- W1899752912 cites W2010559487 @default.
- W1899752912 cites W2019532828 @default.
- W1899752912 cites W2024077848 @default.
- W1899752912 cites W2025267708 @default.
- W1899752912 cites W2027646237 @default.
- W1899752912 cites W2028139115 @default.
- W1899752912 cites W2028446510 @default.
- W1899752912 cites W2030493262 @default.
- W1899752912 cites W2034379109 @default.
- W1899752912 cites W2035790314 @default.
- W1899752912 cites W2039842586 @default.
- W1899752912 cites W2041161248 @default.
- W1899752912 cites W2047857185 @default.
- W1899752912 cites W2050268523 @default.
- W1899752912 cites W2050761459 @default.
- W1899752912 cites W2052493267 @default.
- W1899752912 cites W2053893823 @default.
- W1899752912 cites W2056166262 @default.
- W1899752912 cites W2057648744 @default.
- W1899752912 cites W2063001043 @default.
- W1899752912 cites W2064956950 @default.
- W1899752912 cites W2066991415 @default.
- W1899752912 cites W2067714902 @default.
- W1899752912 cites W2074263471 @default.
- W1899752912 cites W2075695831 @default.
- W1899752912 cites W2076260270 @default.
- W1899752912 cites W2085843752 @default.
- W1899752912 cites W2086396788 @default.
- W1899752912 cites W2087646337 @default.
- W1899752912 cites W2087941260 @default.
- W1899752912 cites W2095245907 @default.
- W1899752912 cites W2097117885 @default.
- W1899752912 cites W2104935326 @default.
- W1899752912 cites W2113060075 @default.
- W1899752912 cites W2115914792 @default.
- W1899752912 cites W2117342688 @default.
- W1899752912 cites W2119437000 @default.
- W1899752912 cites W2121669136 @default.
- W1899752912 cites W2127492558 @default.
- W1899752912 cites W2131376910 @default.
- W1899752912 cites W2132105766 @default.
- W1899752912 cites W2132445147 @default.
- W1899752912 cites W2134444154 @default.
- W1899752912 cites W2136376178 @default.
- W1899752912 cites W2137869737 @default.
- W1899752912 cites W2140372161 @default.
- W1899752912 cites W2142546120 @default.
- W1899752912 cites W2146439590 @default.
- W1899752912 cites W2149037336 @default.
- W1899752912 cites W2149116434 @default.
- W1899752912 cites W2150926065 @default.
- W1899752912 cites W2155408559 @default.
- W1899752912 cites W2158294445 @default.
- W1899752912 cites W2160129587 @default.
- W1899752912 cites W2168660808 @default.
- W1899752912 cites W2327471638 @default.
- W1899752912 cites W2328228059 @default.
- W1899752912 cites W2328378226 @default.
- W1899752912 cites W4299303240 @default.