Matches in SemOpenAlex for { <https://semopenalex.org/work/W1899897445> ?p ?o ?g. }
- W1899897445 endingPage "2804" @default.
- W1899897445 startingPage "2796" @default.
- W1899897445 abstract "Previous studies have shown that the Notch1 and TGF-beta signaling pathways are mutually re-enforcing. Given recent evidence that regulatory T cell (Treg) effector function is mediated by TGF-beta signaling, we investigated whether Notch1 signaling also participated in Treg effector function. Initial studies showed that Notch1 ligands, particularly Jagged1, are present on Tregs and that, indeed, blockade of Notch1 signaling with an anti-Jagged1 or a blocking anti-Notch1 Ab inhibits Treg suppressor function in vitro. We then showed that a signaling component generated by Notch1 activation (Notch1 intracellular domain) of dendritic cells physically interacts with a signaling component generated by TGF-beta signaling (pSmad3). Furthermore, this interaction has functional downstream effects because over-expression of Notch1 intracellular domain facilitates pSmad3 translocation to the nucleus and enhances pSmad3 transcriptional activity of a Smad-sensitive promoter linked to a luciferase reporter. Finally, we showed that blockade of TGF-beta signaling and Notch signaling did not have additive inhibitory effects on Treg suppressor function. These results are consistent with the conclusion that Notch1 signaling facilitates TGF-beta-mediated effector function of Tregs." @default.
- W1899897445 created "2016-06-24" @default.
- W1899897445 creator A5034851349 @default.
- W1899897445 creator A5051210772 @default.
- W1899897445 creator A5053370481 @default.
- W1899897445 creator A5056842523 @default.
- W1899897445 creator A5078914737 @default.
- W1899897445 date "2008-03-01" @default.
- W1899897445 modified "2023-10-18" @default.
- W1899897445 title "Notch1 Signaling and Regulatory T Cell Function" @default.
- W1899897445 cites W1509517161 @default.
- W1899897445 cites W1516366539 @default.
- W1899897445 cites W1518759830 @default.
- W1899897445 cites W1530044612 @default.
- W1899897445 cites W1542406910 @default.
- W1899897445 cites W1572225000 @default.
- W1899897445 cites W1661750169 @default.
- W1899897445 cites W1745273943 @default.
- W1899897445 cites W1898102248 @default.
- W1899897445 cites W1962132325 @default.
- W1899897445 cites W1965543291 @default.
- W1899897445 cites W1968673182 @default.
- W1899897445 cites W1978146894 @default.
- W1899897445 cites W1983173932 @default.
- W1899897445 cites W2026545194 @default.
- W1899897445 cites W2028050458 @default.
- W1899897445 cites W2033260397 @default.
- W1899897445 cites W2036582868 @default.
- W1899897445 cites W2041843279 @default.
- W1899897445 cites W2043180327 @default.
- W1899897445 cites W2045884854 @default.
- W1899897445 cites W2047820200 @default.
- W1899897445 cites W2063197903 @default.
- W1899897445 cites W2064316796 @default.
- W1899897445 cites W2071360012 @default.
- W1899897445 cites W2074576643 @default.
- W1899897445 cites W2093518810 @default.
- W1899897445 cites W2102578057 @default.
- W1899897445 cites W2109001750 @default.
- W1899897445 cites W2119610104 @default.
- W1899897445 cites W2122689765 @default.
- W1899897445 cites W2124975442 @default.
- W1899897445 cites W2130253814 @default.
- W1899897445 cites W2139226941 @default.
- W1899897445 cites W2139839202 @default.
- W1899897445 cites W2141870048 @default.
- W1899897445 cites W2144281230 @default.
- W1899897445 cites W2145499731 @default.
- W1899897445 cites W2147389132 @default.
- W1899897445 cites W2149914697 @default.
- W1899897445 cites W2152244674 @default.
- W1899897445 cites W2152329008 @default.
- W1899897445 cites W2154538286 @default.
- W1899897445 cites W2155521069 @default.
- W1899897445 cites W2158937563 @default.
- W1899897445 cites W2159146866 @default.
- W1899897445 cites W2161545566 @default.
- W1899897445 cites W2164872587 @default.
- W1899897445 cites W2167293538 @default.
- W1899897445 cites W4313324526 @default.
- W1899897445 cites W4321429568 @default.
- W1899897445 doi "https://doi.org/10.4049/jimmunol.180.5.2796" @default.
- W1899897445 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18292500" @default.
- W1899897445 hasPublicationYear "2008" @default.
- W1899897445 type Work @default.
- W1899897445 sameAs 1899897445 @default.
- W1899897445 citedByCount "84" @default.
- W1899897445 countsByYear W18998974452012 @default.
- W1899897445 countsByYear W18998974452013 @default.
- W1899897445 countsByYear W18998974452014 @default.
- W1899897445 countsByYear W18998974452015 @default.
- W1899897445 countsByYear W18998974452016 @default.
- W1899897445 countsByYear W18998974452017 @default.
- W1899897445 countsByYear W18998974452018 @default.
- W1899897445 countsByYear W18998974452019 @default.
- W1899897445 countsByYear W18998974452020 @default.
- W1899897445 countsByYear W18998974452021 @default.
- W1899897445 countsByYear W18998974452022 @default.
- W1899897445 countsByYear W18998974452023 @default.
- W1899897445 crossrefType "journal-article" @default.
- W1899897445 hasAuthorship W1899897445A5034851349 @default.
- W1899897445 hasAuthorship W1899897445A5051210772 @default.
- W1899897445 hasAuthorship W1899897445A5053370481 @default.
- W1899897445 hasAuthorship W1899897445A5056842523 @default.
- W1899897445 hasAuthorship W1899897445A5078914737 @default.
- W1899897445 hasBestOaLocation W18998974451 @default.
- W1899897445 hasConcept C104317684 @default.
- W1899897445 hasConcept C14036430 @default.
- W1899897445 hasConcept C150555746 @default.
- W1899897445 hasConcept C161879069 @default.
- W1899897445 hasConcept C179185449 @default.
- W1899897445 hasConcept C185592680 @default.
- W1899897445 hasConcept C2781080636 @default.
- W1899897445 hasConcept C51785407 @default.
- W1899897445 hasConcept C55493867 @default.
- W1899897445 hasConcept C62478195 @default.
- W1899897445 hasConcept C65114990 @default.
- W1899897445 hasConcept C79879829 @default.