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- W1900028656 abstract "Background : Pulmonary endarterectomy is the treatment of choice for a majority of patients with chronic thromboembolicpulmonary hypertension (CTEPH), however, haemodynamic criteria for the surgery have not been established. It is stillunknown whether patients with mild CTEPH should be operated on and what is the clinical course of unoperated, anticoagulatedmild CTEPH. Aim : To determine the clinical course in chronically anticoagulated, unoperated patients with mild CTEPH. Methods : A single-centre, non-randomised, follow-up study involved 10 anticoagulated, unoperated patients (3 males and7 females aged 46 to 77 years) with mild CTEPH (mean pulmonary artery pressure [MPAP] £ 30 mm Hg and pulmonaryvascular resistance £ 300 dynes ¥ s ¥ cm –5 , ≥ 2 METs achieved during symptom limited treadmill exercise test) selectedfrom 73 consecutive patients with CTEPH. The 3-year follow up included yearly echocardiographic evaluation of pulmonaryartery systolic pressure (PASP), right ventricular end-diastolic diameter (RVEDD) and acceleration time (AcT) as well as NYHAfunctional class and symptom-limited treadmill exercise test. Results : All the patients survived the 3-year follow-up. The PASP, RVEDD and AcT (mean ± SD) at baseline and at theend of follow-up were 43.9 ± 6.1 mm Hg and 25.6 ± 8.0 mm Hg, p = 0.0017, 25.4 ± 4.9 mm and 17.8 ± 3.82 mm,p = 0.00006, 68.3 ± 10.0 ms and 104.4 ± 16.48 ms, p = 0.0004, respectively. The NYHA functional class improved from2.1 ± 0.32 to 1.3 ± 0.48, p = 0.002 and was accompanied by the trend to improve results of exercise test. Conclusions : The results of the study suggest that patients with mild CTEPH can be treated successfully by anticoagulationalone with excellent 3-year survival rate, improved functional status and with gradual decrease of pulmonary pressure andright ventricular overload. Kardiol Pol 2011; 69, 5: 438–443" @default.
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- W1900028656 date "2011-01-01" @default.
- W1900028656 modified "2023-09-24" @default.
- W1900028656 title "Clinical course of unoperated mild chronic thromboembolic pulmonary hypertension." @default.
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