FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1900066480> ?p ?o ?g. }

• W1900066480 endingPage "168" @default.
• W1900066480 startingPage "160" @default.
• W1900066480 abstract "Aims: Intervention studies have shown that angiotensin receptor blockers (ARB) may reduce the incidence of type 2 diabetes mellitus. It is currently unclear whether short-term therapy with ARBs affects metabolic parameters. Methods: i-RESPOND, a randomised, controlled, multicentre, double-blind study evaluated the effect of 16 weeks of irbesartan vs. hydrochlorothiazide (HCTZ) on insulin resistance as well as on lipid and inflammatory parameters in hypertensive subjects with metabolic syndrome. Patients received irbesartan (150 mg/d; n = 211) or HCTZ (12.5 mg/d; n = 215), titrated to 300 mg/day and 25 mg/day respectively. In a second part of the study (weeks 16–28), patients initially randomised to irbesartan received additional HCTZ and vice versa. Results: At week 16 both irbesartan and HCTZ had no effect on insulin resistance measured by the Matzuda index and beta-cell function. Similarly, in the second part of the study (week 16–28) no differences between irbesartan and HCTZ with respect to glucose metabolism were observed. However, irbesartan induced beneficial changes in high-sensitivity-C-reactive protein (hs-CRP) (irbesartan: −5.5 ± 5.2%; HCTZ + 19.9 ± 6.5%, p = 0.0024) and in urinary albumin/creatinine ratio (ACR) (irbesartan: −13%; HCTZ + 9%; p = 0.0041) compared with HCTZ despite a similar decrease in blood pressure in both treatment groups. Irbesartan and HCTZ were well tolerated and adverse events were comparable. Conclusion: Irbesartan did not show significant favourable effects on insulin resistance compared with HCTZ in this study; however, may have beneficial effects on inflammation and microalbuminuria in hypertensive patients with metabolic syndrome." @default.
• W1900066480 created "2016-06-24" @default.
• W1900066480 creator A5011164322 @default.
• W1900066480 creator A5021777258 @default.
• W1900066480 creator A5034383160 @default.
• W1900066480 creator A5051153455 @default.
• W1900066480 creator A5060577165 @default.
• W1900066480 creator A5073917506 @default.
• W1900066480 date "2009-11-19" @default.
• W1900066480 modified "2023-10-17" @default.
• W1900066480 title "Irbesartan has no short-term effect on insulin resistance in hypertensive patients with additional cardiometabolic risk factors (i-RESPOND)" @default.
• W1900066480 cites W1497461844 @default.
• W1900066480 cites W1783195625 @default.
• W1900066480 cites W1966447246 @default.
• W1900066480 cites W1968969864 @default.
• W1900066480 cites W1986349550 @default.
• W1900066480 cites W1988948859 @default.
• W1900066480 cites W1997047615 @default.
• W1900066480 cites W2007653610 @default.
• W1900066480 cites W2008372154 @default.
• W1900066480 cites W2013228583 @default.
• W1900066480 cites W2022841004 @default.
• W1900066480 cites W2025772414 @default.
• W1900066480 cites W2038844856 @default.
• W1900066480 cites W2039102693 @default.
• W1900066480 cites W2043875701 @default.
• W1900066480 cites W2044773944 @default.
• W1900066480 cites W2048748448 @default.
• W1900066480 cites W2051259089 @default.
• W1900066480 cites W2078600320 @default.
• W1900066480 cites W2107732097 @default.
• W1900066480 cites W2113273743 @default.
• W1900066480 cites W2126516593 @default.
• W1900066480 cites W2129697991 @default.
• W1900066480 cites W2129991662 @default.
• W1900066480 cites W2135473035 @default.
• W1900066480 cites W2137298057 @default.
• W1900066480 cites W2137408480 @default.
• W1900066480 cites W2139016545 @default.
• W1900066480 cites W2139638393 @default.
• W1900066480 cites W2141502241 @default.
• W1900066480 cites W2141659719 @default.
• W1900066480 cites W2150278133 @default.
• W1900066480 cites W2156121263 @default.
• W1900066480 cites W2159854507 @default.
• W1900066480 cites W2162506832 @default.
• W1900066480 cites W2164310769 @default.
• W1900066480 cites W2165824673 @default.
• W1900066480 cites W2168493982 @default.
• W1900066480 cites W2172032309 @default.
• W1900066480 cites W2303651371 @default.
• W1900066480 cites W2562329777 @default.
• W1900066480 cites W3021250193 @default.
• W1900066480 cites W4230870013 @default.
• W1900066480 cites W4241031718 @default.
• W1900066480 cites W75245760 @default.
• W1900066480 doi "https://doi.org/10.1111/j.1742-1241.2009.02246.x" @default.
• W1900066480 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19929980" @default.
• W1900066480 hasPublicationYear "2009" @default.
• W1900066480 type Work @default.
• W1900066480 sameAs 1900066480 @default.
• W1900066480 citedByCount "7" @default.
• W1900066480 countsByYear W19000664802012 @default.
• W1900066480 countsByYear W19000664802013 @default.
• W1900066480 countsByYear W19000664802014 @default.
• W1900066480 countsByYear W19000664802015 @default.
• W1900066480 countsByYear W19000664802018 @default.
• W1900066480 crossrefType "journal-article" @default.
• W1900066480 hasAuthorship W1900066480A5011164322 @default.
• W1900066480 hasAuthorship W1900066480A5021777258 @default.
• W1900066480 hasAuthorship W1900066480A5034383160 @default.
• W1900066480 hasAuthorship W1900066480A5051153455 @default.
• W1900066480 hasAuthorship W1900066480A5060577165 @default.
• W1900066480 hasAuthorship W1900066480A5073917506 @default.
• W1900066480 hasConcept C126322002 @default.
• W1900066480 hasConcept C134018914 @default.
• W1900066480 hasConcept C2777180221 @default.
• W1900066480 hasConcept C2777391703 @default.
• W1900066480 hasConcept C2780259554 @default.
• W1900066480 hasConcept C2780361556 @default.
• W1900066480 hasConcept C2781203188 @default.
• W1900066480 hasConcept C555293320 @default.
• W1900066480 hasConcept C71924100 @default.
• W1900066480 hasConcept C84393581 @default.
• W1900066480 hasConceptScore W1900066480C126322002 @default.
• W1900066480 hasConceptScore W1900066480C134018914 @default.
• W1900066480 hasConceptScore W1900066480C2777180221 @default.
• W1900066480 hasConceptScore W1900066480C2777391703 @default.
• W1900066480 hasConceptScore W1900066480C2780259554 @default.
• W1900066480 hasConceptScore W1900066480C2780361556 @default.
• W1900066480 hasConceptScore W1900066480C2781203188 @default.
• W1900066480 hasConceptScore W1900066480C555293320 @default.
• W1900066480 hasConceptScore W1900066480C71924100 @default.
• W1900066480 hasConceptScore W1900066480C84393581 @default.
• W1900066480 hasIssue "2" @default.
• W1900066480 hasLocation W19000664801 @default.
• W1900066480 hasLocation W19000664802 @default.
• W1900066480 hasOpenAccess W1900066480 @default.

• next