FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W190033982> ?p ?o ?g. }

• W190033982 endingPage "1032" @default.
• W190033982 startingPage "1028" @default.
• W190033982 abstract "Summary The optimal intensity of oral anticoagulant therapy for the prevention of thromboembolism in patients with antiphospholipid antibodies (APLA) and systemic lupus erythematosus is controversial. Retrospective studies have suggested that patients with APLA are resistant to oral anticoagulant therapy, with a targeted International Normalization Ratio (INR) of 2.0 to 3.0, and that a higher intensity of anticoagulation (INR: 2.6 to 4.5) is required to prevent recurrent thromboembolism. To investigate if patients with APLA are resistant to the anticoagulant effect of low intensities of warfarin therapy, we performed a randomized trial in which 21 patients with APLA and systemic lupus erythematosus were allocated to receive one of three intensities of warfarin (INR: 1.1 to 1.4, 1.5 to 1.9 or 2.0 to 2.5) or placebo for four months. The main outcome was the effect of each intensity of warfarin therapy on prothrombin fragment 1+2 level (F1+2), that was used as a marker of coagulation activation. When F1+2 levels in patients allocated to the three warfarin intensities were compared to F1+2 levels in the placebo group, there was a statistically significant decrease (p <0.05) in the patient group receiving warfarin with a targeted INR of 2.0 to 2.5 at two, three and four months, and in the patient group with a targeted of INR 1.5 to 1.9 at three months. We conclude that in patients with APLA and systemic lupus erythematosus, warfarin therapy, with a targeted INR of 2.0 to 2.5, is effective in suppressing coagulation activation, and therefore, might be effective in preventing thromboembolism." @default.
• W190033982 created "2016-06-24" @default.
• W190033982 creator A5018161501 @default.
• W190033982 creator A5022175730 @default.
• W190033982 creator A5031899801 @default.
• W190033982 creator A5055721179 @default.
• W190033982 creator A5055785288 @default.
• W190033982 creator A5069466103 @default.
• W190033982 creator A5070338572 @default.
• W190033982 creator A5079941141 @default.
• W190033982 date "1999-01-01" @default.
• W190033982 modified "2023-09-27" @default.
• W190033982 title "The Effects of Low-intensity Warfarin on Coagulation Activation in Patients with Antiphospholipid Antibodies and Systemic Lupus Erythematosus" @default.
• W190033982 cites W124985240 @default.
• W190033982 cites W166703492 @default.
• W190033982 cites W168978929 @default.
• W190033982 cites W170551571 @default.
• W190033982 cites W1901279264 @default.
• W190033982 cites W1980784832 @default.
• W190033982 cites W1981746689 @default.
• W190033982 cites W1996667418 @default.
• W190033982 cites W2012757283 @default.
• W190033982 cites W2032105970 @default.
• W190033982 cites W2070477088 @default.
• W190033982 cites W2100184560 @default.
• W190033982 cites W2109451688 @default.
• W190033982 cites W2125646842 @default.
• W190033982 cites W2141062748 @default.
• W190033982 cites W2152348310 @default.
• W190033982 cites W2152900444 @default.
• W190033982 cites W2157778986 @default.
• W190033982 cites W2163428021 @default.
• W190033982 cites W2178797281 @default.
• W190033982 cites W2256723314 @default.
• W190033982 cites W2258076533 @default.
• W190033982 cites W2314358062 @default.
• W190033982 cites W2327141264 @default.
• W190033982 cites W2331935930 @default.
• W190033982 cites W2333330110 @default.
• W190033982 cites W2337130116 @default.
• W190033982 cites W2400001338 @default.
• W190033982 cites W2408898441 @default.
• W190033982 cites W2409445331 @default.
• W190033982 cites W2411487456 @default.
• W190033982 cites W2432864869 @default.
• W190033982 cites W2468801568 @default.
• W190033982 cites W265405240 @default.
• W190033982 cites W44202489 @default.
• W190033982 cites W93524816 @default.
• W190033982 doi "https://doi.org/10.1055/s-0037-1614324" @default.
• W190033982 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10494759" @default.
• W190033982 hasPublicationYear "1999" @default.
• W190033982 type Work @default.
• W190033982 sameAs 190033982 @default.
• W190033982 citedByCount "25" @default.
• W190033982 countsByYear W1900339822015 @default.
• W190033982 countsByYear W1900339822018 @default.
• W190033982 countsByYear W1900339822019 @default.
• W190033982 crossrefType "journal-article" @default.
• W190033982 hasAuthorship W190033982A5018161501 @default.
• W190033982 hasAuthorship W190033982A5022175730 @default.
• W190033982 hasAuthorship W190033982A5031899801 @default.
• W190033982 hasAuthorship W190033982A5055721179 @default.
• W190033982 hasAuthorship W190033982A5055785288 @default.
• W190033982 hasAuthorship W190033982A5069466103 @default.
• W190033982 hasAuthorship W190033982A5070338572 @default.
• W190033982 hasAuthorship W190033982A5079941141 @default.
• W190033982 hasConcept C126322002 @default.
• W190033982 hasConcept C142724271 @default.
• W190033982 hasConcept C204787440 @default.
• W190033982 hasConcept C27081682 @default.
• W190033982 hasConcept C2776301958 @default.
• W190033982 hasConcept C2776874634 @default.
• W190033982 hasConcept C2778205648 @default.
• W190033982 hasConcept C2779161974 @default.
• W190033982 hasConcept C2780022809 @default.
• W190033982 hasConcept C2780434524 @default.
• W190033982 hasConcept C2780868729 @default.
• W190033982 hasConcept C71924100 @default.
• W190033982 hasConcept C90924648 @default.
• W190033982 hasConceptScore W190033982C126322002 @default.
• W190033982 hasConceptScore W190033982C142724271 @default.
• W190033982 hasConceptScore W190033982C204787440 @default.
• W190033982 hasConceptScore W190033982C27081682 @default.
• W190033982 hasConceptScore W190033982C2776301958 @default.
• W190033982 hasConceptScore W190033982C2776874634 @default.
• W190033982 hasConceptScore W190033982C2778205648 @default.
• W190033982 hasConceptScore W190033982C2779161974 @default.
• W190033982 hasConceptScore W190033982C2780022809 @default.
• W190033982 hasConceptScore W190033982C2780434524 @default.
• W190033982 hasConceptScore W190033982C2780868729 @default.
• W190033982 hasConceptScore W190033982C71924100 @default.
• W190033982 hasConceptScore W190033982C90924648 @default.
• W190033982 hasFunder F4320324195 @default.
• W190033982 hasIssue "09" @default.
• W190033982 hasLocation W1900339821 @default.
• W190033982 hasLocation W1900339822 @default.
• W190033982 hasOpenAccess W190033982 @default.

• next