FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1900387077> ?p ?o ?g. }

• W1900387077 endingPage "978" @default.
• W1900387077 startingPage "969" @default.
• W1900387077 abstract "The vertebrate embryonic body plan is constructed through the interaction of many developmentally regulated genes that supply cells with the essential positional and functional information they require to migrate to their appropriate destination and generate the proper structures. Some molecular cues involved in patterning the central nervous system, particularly in the hindbrain, are interpreted by the Hox homeobox genes. Retinoids can affect the expression of Hox genes in cells lines and embryonic tissues; the hindbrain and branchial region of the head are particularly sensitive to the teratogenic effects of retinoic acid. The presence of endogenous retinoic acid, together with the distribution of retinoid binding proteins and nuclear receptors in the developing embryo, strongly suggest that retinoic acid is a natural morphogen in vertebrate development. The molecular basis for the interaction between retinoic acid and the Hox genes has been aided in part by approaches using deletion analysis in transgenic mice carrying lacZ reporter constructs. Such studies have identified functional retinoic acid response elements within flanking sequences of some of the most 3' Hox genes, suggesting a direct interaction between the genes and retinoic acid. Furthermore, as demonstrated using transgenic mice carrying Hoxb-1/lacZ constructs, multiple retinoic acid response elements may cooperate with positive and negative regulatory enhancers to specify pattern formation in the vertebrate embryo. These types of studies strongly support the normal roles of retinoids in patterning vertebrate embryogenesis through the Hox genes." @default.
• W1900387077 created "2016-06-24" @default.
• W1900387077 creator A5007596395 @default.
• W1900387077 creator A5009690607 @default.
• W1900387077 creator A5015222167 @default.
• W1900387077 creator A5029217631 @default.
• W1900387077 creator A5089207995 @default.
• W1900387077 date "1996-07-01" @default.
• W1900387077 modified "2023-10-17" @default.
• W1900387077 title "Retinoids and <i>Hox</i> genes" @default.
• W1900387077 cites W157053982 @default.
• W1900387077 cites W1817142398 @default.
• W1900387077 cites W1835685966 @default.
• W1900387077 cites W1901448151 @default.
• W1900387077 cites W1936954588 @default.
• W1900387077 cites W1963526989 @default.
• W1900387077 cites W1965350971 @default.
• W1900387077 cites W1972294274 @default.
• W1900387077 cites W1976237650 @default.
• W1900387077 cites W1978096077 @default.
• W1900387077 cites W1981451611 @default.
• W1900387077 cites W2006788765 @default.
• W1900387077 cites W2006877541 @default.
• W1900387077 cites W2008668462 @default.
• W1900387077 cites W2011467252 @default.
• W1900387077 cites W2014591899 @default.
• W1900387077 cites W2023003508 @default.
• W1900387077 cites W2027736032 @default.
• W1900387077 cites W2038192335 @default.
• W1900387077 cites W2039603232 @default.
• W1900387077 cites W2042018645 @default.
• W1900387077 cites W2046541575 @default.
• W1900387077 cites W2046859370 @default.
• W1900387077 cites W2048249977 @default.
• W1900387077 cites W2054160429 @default.
• W1900387077 cites W2057433337 @default.
• W1900387077 cites W2062140641 @default.
• W1900387077 cites W2068069263 @default.
• W1900387077 cites W2072173923 @default.
• W1900387077 cites W2074786828 @default.
• W1900387077 cites W2078661919 @default.
• W1900387077 cites W2083436346 @default.
• W1900387077 cites W2084158728 @default.
• W1900387077 cites W2091626902 @default.
• W1900387077 cites W2093937748 @default.
• W1900387077 cites W2098161701 @default.
• W1900387077 cites W2099715509 @default.
• W1900387077 cites W2106807810 @default.
• W1900387077 cites W2133760066 @default.
• W1900387077 cites W2139521310 @default.
• W1900387077 cites W2169284834 @default.
• W1900387077 cites W2169920445 @default.
• W1900387077 cites W2184176235 @default.
• W1900387077 cites W2185605595 @default.
• W1900387077 cites W2187472266 @default.
• W1900387077 cites W2276715922 @default.
• W1900387077 cites W2276923998 @default.
• W1900387077 cites W2291668409 @default.
• W1900387077 cites W2337949001 @default.
• W1900387077 cites W2411745245 @default.
• W1900387077 doi "https://doi.org/10.1096/fasebj.10.9.8801179" @default.
• W1900387077 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8801179" @default.
• W1900387077 hasPublicationYear "1996" @default.
• W1900387077 type Work @default.
• W1900387077 sameAs 1900387077 @default.
• W1900387077 citedByCount "240" @default.
• W1900387077 countsByYear W19003870772012 @default.
• W1900387077 countsByYear W19003870772013 @default.
• W1900387077 countsByYear W19003870772014 @default.
• W1900387077 countsByYear W19003870772015 @default.
• W1900387077 countsByYear W19003870772016 @default.
• W1900387077 countsByYear W19003870772017 @default.
• W1900387077 countsByYear W19003870772018 @default.
• W1900387077 countsByYear W19003870772019 @default.
• W1900387077 countsByYear W19003870772020 @default.
• W1900387077 countsByYear W19003870772021 @default.
• W1900387077 countsByYear W19003870772022 @default.
• W1900387077 crossrefType "journal-article" @default.
• W1900387077 hasAuthorship W1900387077A5007596395 @default.
• W1900387077 hasAuthorship W1900387077A5009690607 @default.
• W1900387077 hasAuthorship W1900387077A5015222167 @default.
• W1900387077 hasAuthorship W1900387077A5029217631 @default.
• W1900387077 hasAuthorship W1900387077A5089207995 @default.
• W1900387077 hasConcept C104317684 @default.
• W1900387077 hasConcept C111039654 @default.
• W1900387077 hasConcept C111936080 @default.
• W1900387077 hasConcept C120197328 @default.
• W1900387077 hasConcept C121587040 @default.
• W1900387077 hasConcept C139522298 @default.
• W1900387077 hasConcept C150194340 @default.
• W1900387077 hasConcept C161733203 @default.
• W1900387077 hasConcept C2777075493 @default.
• W1900387077 hasConcept C2778386714 @default.
• W1900387077 hasConcept C2781121885 @default.
• W1900387077 hasConcept C54355233 @default.
• W1900387077 hasConcept C80261634 @default.
• W1900387077 hasConcept C86803240 @default.
• W1900387077 hasConcept C89364313 @default.

• next