Matches in SemOpenAlex for { <https://semopenalex.org/work/W1900387932> ?p ?o ?g. }
- W1900387932 endingPage "14" @default.
- W1900387932 startingPage "208" @default.
- W1900387932 abstract "Although tricyclic antidepressant (TCA) blockade of cardiac Na+ channels is appreciated, actions on neuronal Na+ channels are less clear. Therefore, the effects of TCAs (amitriptyline, doxepin and desipramine) as well as trazdone and fluoxetine on voltage-gated Na+ current (INa) were examined in bovine adrenal chromaffin cells using the whole-cell patch-clamp method. Amitriptyline produced concentration-dependent depression of peak INa evoked from a holding potential of -80 mV with KD value of 20.2 microM and a Hill coefficient of 1.2. Although 20 microM amitriptyline induced no change in the rate or voltage dependence of INa activation, steady-state inactivation demonstrated a 15-mV hyperpolarizing shift. Similar results were observed for doxepin and desipramine. This shift in steady-state inactivation was associated with a slowed rate of recovery from the inactivated state. Contrasting results were observed with the atypical antidepressants: while 20 microM fluoxetine depressed peak INa by 61% and caused a 7-mV hyperpolarizing shift in steady-state inactivation, 100 microM trazodone decreased peak INa by only 19% and caused only a 3-mV shift. Although the magnitude of fluoxetine effects was similar to those of the TCAs, the onset of fluoxetine effects was substantially slower than for amitriptyline. In voltage-clamp and current-clamp measurements from neonatal rat dorsal root ganglion neurons, 20 microM amitriptyline decreased INa by 52% and depressed action potential dynamics consistent with enhanced Na+ channel inactivation. The effects of the TCAs on INa are similar to local anesthetic behavior and could contribute to certain analgesic actions." @default.
- W1900387932 created "2016-06-24" @default.
- W1900387932 creator A5036651934 @default.
- W1900387932 creator A5048915941 @default.
- W1900387932 creator A5083434443 @default.
- W1900387932 creator A5086846420 @default.
- W1900387932 date "1998-01-01" @default.
- W1900387932 modified "2023-10-03" @default.
- W1900387932 title "Inhibition of neuronal Na+ channels by antidepressant drugs." @default.
- W1900387932 cites W1482513578 @default.
- W1900387932 cites W1564009326 @default.
- W1900387932 cites W1574624502 @default.
- W1900387932 cites W1848126947 @default.
- W1900387932 cites W1858818584 @default.
- W1900387932 cites W1970616248 @default.
- W1900387932 cites W1971702542 @default.
- W1900387932 cites W1974295986 @default.
- W1900387932 cites W1976750269 @default.
- W1900387932 cites W1983572531 @default.
- W1900387932 cites W1985051584 @default.
- W1900387932 cites W1993584057 @default.
- W1900387932 cites W2002197506 @default.
- W1900387932 cites W2009185989 @default.
- W1900387932 cites W2009667219 @default.
- W1900387932 cites W2010827474 @default.
- W1900387932 cites W2022050392 @default.
- W1900387932 cites W2022432610 @default.
- W1900387932 cites W2029009945 @default.
- W1900387932 cites W2039262751 @default.
- W1900387932 cites W2039788784 @default.
- W1900387932 cites W2042285770 @default.
- W1900387932 cites W2043442353 @default.
- W1900387932 cites W2043554960 @default.
- W1900387932 cites W2061603952 @default.
- W1900387932 cites W2067995523 @default.
- W1900387932 cites W2081363425 @default.
- W1900387932 cites W2084911408 @default.
- W1900387932 cites W2102038880 @default.
- W1900387932 cites W2108771826 @default.
- W1900387932 cites W2126191204 @default.
- W1900387932 cites W2128198304 @default.
- W1900387932 cites W2134321467 @default.
- W1900387932 cites W2135239295 @default.
- W1900387932 cites W2150883260 @default.
- W1900387932 cites W2154637671 @default.
- W1900387932 cites W2169447022 @default.
- W1900387932 cites W2268120706 @default.
- W1900387932 cites W2328445755 @default.
- W1900387932 cites W2422118345 @default.
- W1900387932 cites W2460598618 @default.
- W1900387932 cites W2465651915 @default.
- W1900387932 cites W3035877465 @default.
- W1900387932 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9435180" @default.
- W1900387932 hasPublicationYear "1998" @default.
- W1900387932 type Work @default.
- W1900387932 sameAs 1900387932 @default.
- W1900387932 citedByCount "94" @default.
- W1900387932 countsByYear W19003879322012 @default.
- W1900387932 countsByYear W19003879322013 @default.
- W1900387932 countsByYear W19003879322014 @default.
- W1900387932 countsByYear W19003879322015 @default.
- W1900387932 countsByYear W19003879322016 @default.
- W1900387932 countsByYear W19003879322017 @default.
- W1900387932 countsByYear W19003879322018 @default.
- W1900387932 countsByYear W19003879322019 @default.
- W1900387932 countsByYear W19003879322020 @default.
- W1900387932 countsByYear W19003879322022 @default.
- W1900387932 countsByYear W19003879322023 @default.
- W1900387932 crossrefType "journal-article" @default.
- W1900387932 hasAuthorship W1900387932A5036651934 @default.
- W1900387932 hasAuthorship W1900387932A5048915941 @default.
- W1900387932 hasAuthorship W1900387932A5083434443 @default.
- W1900387932 hasAuthorship W1900387932A5086846420 @default.
- W1900387932 hasConcept C105702510 @default.
- W1900387932 hasConcept C126322002 @default.
- W1900387932 hasConcept C134018914 @default.
- W1900387932 hasConcept C140530291 @default.
- W1900387932 hasConcept C147944092 @default.
- W1900387932 hasConcept C170493617 @default.
- W1900387932 hasConcept C178790620 @default.
- W1900387932 hasConcept C185263204 @default.
- W1900387932 hasConcept C185592680 @default.
- W1900387932 hasConcept C2775864247 @default.
- W1900387932 hasConcept C2776134451 @default.
- W1900387932 hasConcept C2776281502 @default.
- W1900387932 hasConcept C2779177272 @default.
- W1900387932 hasConcept C2780216858 @default.
- W1900387932 hasConcept C2780250439 @default.
- W1900387932 hasConcept C2780831388 @default.
- W1900387932 hasConcept C2780980600 @default.
- W1900387932 hasConcept C2781081902 @default.
- W1900387932 hasConcept C2781161787 @default.
- W1900387932 hasConcept C42219234 @default.
- W1900387932 hasConcept C50952357 @default.
- W1900387932 hasConcept C537181965 @default.
- W1900387932 hasConcept C55493867 @default.
- W1900387932 hasConcept C71924100 @default.
- W1900387932 hasConcept C98274493 @default.