FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1900503590> ?p ?o ?g. }

• W1900503590 abstract "Background: Despite its insulin-sensitizing and atheroprotective properties, higher plasma adiponectin (APN) has been linked to increased mortality in older adults. The basis for this adverse association is not well delineated, but natriuretic peptides (NPs) have been invoked as a potential explanation because they are known to stimulate APN secretion. One prospective study showed that adjustment for baseline NP levels attenuated APN’s relationship with mortality, but another demonstrated persistence despite such adjustment. The relationship between serial changes in NP and APN levels, however, and their association with fatal events, has not been previously examined. Methods: We used linear regression to estimate the association of change (Δ) in N-terminal pro-B-type natriuretic peptide (NT-proBNP) with concurrent ΔAPN, and Cox regression to estimate the relative risk of death for ΔNT-proBNP and ΔAPN in a population-based study of older adults (Cardiovascular Health Study). NT-proBNP and APN were measured in stored plasma from the 1996 exam to complement previous measures of both analytes obtained at the 1992 exam. There were n=2669 participants with all measures; APN values were well harmonized across the 2 exams, but because NT-proBNP values >1000 pg/ml were not, we excluded such values (n=238) from the primary analysis. Both annualized change and average level across both years were considered in order to distinguish true change from improved precision from repeated measurement. Results: Age 77±4 yrs, 62% women; ΔNT-proBNP 15±37 pg/mL/yr; ΔAPN 0.3±1.2 mg/L/yr. After full adjustment (age, sex, race, smoking, alcohol, Δweight, Δglucose, albumin, medications, prevalent CVD, health status, eGFR, and CRP), ΔNT-proBNP, but not mean NT-proBNP, was positively associated with ΔAPN (0.1 mg/L/yr [0.06, 0.16] APN increase per SD increment in ΔNT-proBNP). During follow-up through 2010, 1792 participants died. In fully adjusted models, both mean APN and ΔAPN were significantly associated with mortality (HR per SD increment 1.06 [1.00, 1.12] and 1.1 [1.05, 1.16], respectively), whereas mean NT-proBNP (1.25 [1.18, 1.33]), but not ΔNT-proBNP, was significantly related to this outcome. When both measures of APN & NT-proBNP were included in a fully adjusted model, mean APN ceased to be significant, but associations of ΔAPN and mean NT-proBNP with mortality were not materially changed. Sensitivity analysis including NT-proBNP >1000 pg/mL with winsorization at the upper 99th %ile of NT-proBNP showed similar findings. Conclusion: These findings provide new insights into APN’s association with mortality in older adults, showing that (i) longitudinal change in NT-proBNP is associated with change in APN; and (ii) it is this longitudinal change in APN, independent of concurrent change or average level of NT-proBNP, but not the adipokine’s mean level, that is associated with increased mortality." @default.
• W1900503590 created "2016-06-24" @default.
• W1900503590 creator A5007241513 @default.
• W1900503590 creator A5023858070 @default.
• W1900503590 creator A5023969759 @default.
• W1900503590 creator A5031077891 @default.
• W1900503590 creator A5039797196 @default.
• W1900503590 creator A5052674061 @default.
• W1900503590 creator A5064816095 @default.
• W1900503590 creator A5071573513 @default.
• W1900503590 creator A5076440538 @default.
• W1900503590 creator A5081670681 @default.
• W1900503590 creator A5089876350 @default.
• W1900503590 date "2015-03-10" @default.
• W1900503590 modified "2023-10-16" @default.
• W1900503590 title "Abstract 49: Changes in Circulating Natriuretic Peptide and Adiponectin Levels and All-cause Mortality in Older People: The Cardiovascular Health Study" @default.
• W1900503590 hasPublicationYear "2015" @default.
• W1900503590 type Work @default.
• W1900503590 sameAs 1900503590 @default.
• W1900503590 citedByCount "0" @default.
• W1900503590 crossrefType "journal-article" @default.
• W1900503590 hasAuthorship W1900503590A5007241513 @default.
• W1900503590 hasAuthorship W1900503590A5023858070 @default.
• W1900503590 hasAuthorship W1900503590A5023969759 @default.
• W1900503590 hasAuthorship W1900503590A5031077891 @default.
• W1900503590 hasAuthorship W1900503590A5039797196 @default.
• W1900503590 hasAuthorship W1900503590A5052674061 @default.
• W1900503590 hasAuthorship W1900503590A5064816095 @default.
• W1900503590 hasAuthorship W1900503590A5071573513 @default.
• W1900503590 hasAuthorship W1900503590A5076440538 @default.
• W1900503590 hasAuthorship W1900503590A5081670681 @default.
• W1900503590 hasAuthorship W1900503590A5089876350 @default.
• W1900503590 hasConcept C126322002 @default.
• W1900503590 hasConcept C134018914 @default.
• W1900503590 hasConcept C164705383 @default.
• W1900503590 hasConcept C188816634 @default.
• W1900503590 hasConcept C2775915353 @default.
• W1900503590 hasConcept C2776782570 @default.
• W1900503590 hasConcept C2777391703 @default.
• W1900503590 hasConcept C2778198053 @default.
• W1900503590 hasConcept C2779134260 @default.
• W1900503590 hasConcept C2908647359 @default.
• W1900503590 hasConcept C3018284874 @default.
• W1900503590 hasConcept C50382708 @default.
• W1900503590 hasConcept C555293320 @default.
• W1900503590 hasConcept C71924100 @default.
• W1900503590 hasConcept C99454951 @default.
• W1900503590 hasConceptScore W1900503590C126322002 @default.
• W1900503590 hasConceptScore W1900503590C134018914 @default.
• W1900503590 hasConceptScore W1900503590C164705383 @default.
• W1900503590 hasConceptScore W1900503590C188816634 @default.
• W1900503590 hasConceptScore W1900503590C2775915353 @default.
• W1900503590 hasConceptScore W1900503590C2776782570 @default.
• W1900503590 hasConceptScore W1900503590C2777391703 @default.
• W1900503590 hasConceptScore W1900503590C2778198053 @default.
• W1900503590 hasConceptScore W1900503590C2779134260 @default.
• W1900503590 hasConceptScore W1900503590C2908647359 @default.
• W1900503590 hasConceptScore W1900503590C3018284874 @default.
• W1900503590 hasConceptScore W1900503590C50382708 @default.
• W1900503590 hasConceptScore W1900503590C555293320 @default.
• W1900503590 hasConceptScore W1900503590C71924100 @default.
• W1900503590 hasConceptScore W1900503590C99454951 @default.
• W1900503590 hasOpenAccess W1900503590 @default.
• W1900503590 hasRelatedWork W148876507 @default.
• W1900503590 hasRelatedWork W1499249488 @default.
• W1900503590 hasRelatedWork W1526064652 @default.
• W1900503590 hasRelatedWork W1815297513 @default.
• W1900503590 hasRelatedWork W2029004522 @default.
• W1900503590 hasRelatedWork W2076593268 @default.
• W1900503590 hasRelatedWork W2089909589 @default.
• W1900503590 hasRelatedWork W2100013046 @default.
• W1900503590 hasRelatedWork W2123729456 @default.
• W1900503590 hasRelatedWork W2382260077 @default.
• W1900503590 hasRelatedWork W2404135105 @default.
• W1900503590 hasRelatedWork W2404808657 @default.
• W1900503590 hasRelatedWork W2561982313 @default.
• W1900503590 hasRelatedWork W2906956525 @default.
• W1900503590 hasRelatedWork W2921238205 @default.
• W1900503590 hasRelatedWork W2994851663 @default.
• W1900503590 hasRelatedWork W3153889060 @default.
• W1900503590 hasRelatedWork W3182353357 @default.
• W1900503590 hasRelatedWork W2183621160 @default.
• W1900503590 hasRelatedWork W3029850893 @default.
• W1900503590 hasVolume "131" @default.
• W1900503590 isParatext "false" @default.
• W1900503590 isRetracted "false" @default.
• W1900503590 magId "1900503590" @default.
• W1900503590 workType "article" @default.