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• W1900517450 endingPage "832" @default.
• W1900517450 startingPage "811" @default.
• W1900517450 abstract "Abstract Terpenoids are the largest, most diverse class of plant natural products and they play numerous functional roles in primary metabolism and in ecological interactions. The first committed step in the formation of the various terpenoid classes is the transformation of the prenyl diphosphate precursors, geranyl diphosphate, farnesyl diphosphate, and geranylgeranyl diphosphate, to the parent structures of each type catalyzed by the respective monoterpene (C10), sesquiterpene (C15), and diterpene synthases (C20). Over 30 cDNAs encoding plant terpenoid synthases involved in primary and secondary metabolism have been cloned and characterized. Here we describe the isolation and analysis of six genomic clones encoding terpene synthases of conifers, [(-)-pinene (C10), (-)-limonene (C10), (E)-α-bisabolene (C15), δ-selinene (C15), and abietadiene synthase (C20) from Abies grandis and taxadiene synthase (C20) from Taxus brevifolia], all of which are involved in natural products biosynthesis. Genome organization (intron number, size, placement and phase, and exon size) of these gymnosperm terpene synthases was compared to eight previously characterized angiosperm terpene synthase genes and to six putative terpene synthase genomic sequences from Arabidopsis thaliana. Three distinct classes of terpene synthase genes were discerned, from which assumed patterns of sequential intron loss and the loss of an unusual internal sequence element suggest that the ancestral terpenoid synthase gene resembled a contemporary conifer diterpene synthase gene in containing at least 12 introns and 13 exons of conserved size. A model presented for the evolutionary history of plant terpene synthases suggests that this superfamily of genes responsible for natural products biosynthesis derived from terpene synthase genes involved in primary metabolism by duplication and divergence in structural and functional specialization. This novel molecular evolutionary approach focused on genes of secondary metabolism may have broad implications for the origins of natural products and for plant phylogenetics in general." @default.
• W1900517450 created "2016-06-24" @default.
• W1900517450 creator A5060790939 @default.
• W1900517450 creator A5087088205 @default.
• W1900517450 date "2001-06-01" @default.
• W1900517450 modified "2023-10-11" @default.
• W1900517450 title "Genomic Organization of Plant Terpene Synthases and Molecular Evolutionary Implications" @default.
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• W1900517450 doi "https://doi.org/10.1093/genetics/158.2.811" @default.
• W1900517450 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1461696" @default.
• W1900517450 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11404343" @default.
• W1900517450 hasPublicationYear "2001" @default.
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