FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1900525792> ?p ?o ?g. }

• W1900525792 endingPage "348" @default.
• W1900525792 startingPage "341" @default.
• W1900525792 abstract "ABSTRACT BACKGROUND Process analytical technology ( PAT ) is gradually being implemented in the biopharmaceutical industry due to the potential for continuous real‐time quality assurance resulting in improved operational control and compliance. Process chromatography remains the primary unit operation for purification of biotech therapeutics for separation of the various host cell related, process related, and product related impurities and variants. The latter often have very similar physicochemical properties to that of the product and hence in the absence of baseline separation, a robust pooling strategy is required to ensure consistent product quality. RESULTS This paper presents an evaluation of a variety of PAT based and pseudo‐ PAT based approaches for pooling a real commercial process chromatography column. The pseudo‐ PAT approaches that have been evaluated include ultraviolet ( UV ) absorbance, % peak height, retention time, and relative retention time. These approaches do not involve direct measurement of product quality attributes, but are operationally simpler to implement. Two other PAT based approaches have also been considered. The first involves use of a feed forward control based model that uses as an input the retention time of a characteristic peak that elutes prior to the main peak. The second PAT based approach involves use of a rapid HPLC method that can facilitate near‐real‐time decision making on pooling. CONCLUSIONS The paper provides a comparison of the advantages and drawbacks of the various approaches that have been examined and establishes the feasibility of multiple approaches that can facilitate implementation of PAT for pooling of process chromatography columns. © 2014 Society of Chemical Industry" @default.
• W1900525792 created "2016-06-24" @default.
• W1900525792 creator A5000648679 @default.
• W1900525792 creator A5040815462 @default.
• W1900525792 creator A5078008569 @default.
• W1900525792 creator A5082994856 @default.
• W1900525792 date "2014-07-03" @default.
• W1900525792 modified "2023-10-18" @default.
• W1900525792 title "Comparison of PAT based approaches for making real-time pooling decisions for process chromatography - use of feed forward control" @default.
• W1900525792 cites W1480442169 @default.
• W1900525792 cites W1546889383 @default.
• W1900525792 cites W1580783414 @default.
• W1900525792 cites W1964871155 @default.
• W1900525792 cites W1973350855 @default.
• W1900525792 cites W1974345595 @default.
• W1900525792 cites W2006893257 @default.
• W1900525792 cites W2010530023 @default.
• W1900525792 cites W2019859863 @default.
• W1900525792 cites W2021433808 @default.
• W1900525792 cites W2021598569 @default.
• W1900525792 cites W2050728149 @default.
• W1900525792 cites W2051368657 @default.
• W1900525792 cites W2074619604 @default.
• W1900525792 cites W2093540825 @default.
• W1900525792 cites W2101199384 @default.
• W1900525792 cites W2106601030 @default.
• W1900525792 cites W2142533124 @default.
• W1900525792 cites W2150417286 @default.
• W1900525792 cites W2151077707 @default.
• W1900525792 cites W2153236322 @default.
• W1900525792 cites W3004335124 @default.
• W1900525792 cites W4237118585 @default.
• W1900525792 cites W4241141797 @default.
• W1900525792 cites W4379509319 @default.
• W1900525792 doi "https://doi.org/10.1002/jctb.4448" @default.
• W1900525792 hasPublicationYear "2014" @default.
• W1900525792 type Work @default.
• W1900525792 sameAs 1900525792 @default.
• W1900525792 citedByCount "29" @default.
• W1900525792 countsByYear W19005257922014 @default.
• W1900525792 countsByYear W19005257922015 @default.
• W1900525792 countsByYear W19005257922016 @default.
• W1900525792 countsByYear W19005257922017 @default.
• W1900525792 countsByYear W19005257922018 @default.
• W1900525792 countsByYear W19005257922019 @default.
• W1900525792 countsByYear W19005257922020 @default.
• W1900525792 countsByYear W19005257922021 @default.
• W1900525792 countsByYear W19005257922022 @default.
• W1900525792 countsByYear W19005257922023 @default.
• W1900525792 crossrefType "journal-article" @default.
• W1900525792 hasAuthorship W1900525792A5000648679 @default.
• W1900525792 hasAuthorship W1900525792A5040815462 @default.
• W1900525792 hasAuthorship W1900525792A5078008569 @default.
• W1900525792 hasAuthorship W1900525792A5082994856 @default.
• W1900525792 hasConcept C106436119 @default.
• W1900525792 hasConcept C111472728 @default.
• W1900525792 hasConcept C111919701 @default.
• W1900525792 hasConcept C127413603 @default.
• W1900525792 hasConcept C13280743 @default.
• W1900525792 hasConcept C138885662 @default.
• W1900525792 hasConcept C150903083 @default.
• W1900525792 hasConcept C154945302 @default.
• W1900525792 hasConcept C155386361 @default.
• W1900525792 hasConcept C174998907 @default.
• W1900525792 hasConcept C178144697 @default.
• W1900525792 hasConcept C185592680 @default.
• W1900525792 hasConcept C185798385 @default.
• W1900525792 hasConcept C205649164 @default.
• W1900525792 hasConcept C21547014 @default.
• W1900525792 hasConcept C21880701 @default.
• W1900525792 hasConcept C2524010 @default.
• W1900525792 hasConcept C2778618615 @default.
• W1900525792 hasConcept C2779530757 @default.
• W1900525792 hasConcept C2781047461 @default.
• W1900525792 hasConcept C33923547 @default.
• W1900525792 hasConcept C41008148 @default.
• W1900525792 hasConcept C43617362 @default.
• W1900525792 hasConcept C70437156 @default.
• W1900525792 hasConcept C86803240 @default.
• W1900525792 hasConcept C90673727 @default.
• W1900525792 hasConcept C98045186 @default.
• W1900525792 hasConceptScore W1900525792C106436119 @default.
• W1900525792 hasConceptScore W1900525792C111472728 @default.
• W1900525792 hasConceptScore W1900525792C111919701 @default.
• W1900525792 hasConceptScore W1900525792C127413603 @default.
• W1900525792 hasConceptScore W1900525792C13280743 @default.
• W1900525792 hasConceptScore W1900525792C138885662 @default.
• W1900525792 hasConceptScore W1900525792C150903083 @default.
• W1900525792 hasConceptScore W1900525792C154945302 @default.
• W1900525792 hasConceptScore W1900525792C155386361 @default.
• W1900525792 hasConceptScore W1900525792C174998907 @default.
• W1900525792 hasConceptScore W1900525792C178144697 @default.
• W1900525792 hasConceptScore W1900525792C185592680 @default.
• W1900525792 hasConceptScore W1900525792C185798385 @default.
• W1900525792 hasConceptScore W1900525792C205649164 @default.
• W1900525792 hasConceptScore W1900525792C21547014 @default.
• W1900525792 hasConceptScore W1900525792C21880701 @default.
• W1900525792 hasConceptScore W1900525792C2524010 @default.

• next