FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1900528944> ?p ?o ?g. }

• W1900528944 endingPage "6516" @default.
• W1900528944 startingPage "6508" @default.
• W1900528944 abstract "Abstract An important regulatory suppressive function in autoimmune and other inflammatory processes has been ascribed to CD4+Foxp3+ regulatory T cells (Tregs), which requires direct cell-cell communication between Tregs, effector T cells, and APCs. However, the molecular basis for these interactions has not yet been clarified. We show here that sialoadhesin (Sn), the prototype of the siglec family of sialic acid-binding transmembrane proteins, expressed by resident and activated tissue-infiltrating macrophages, directly binds to Tregs, negatively regulating their expansion in an animal model of multiple sclerosis (MS), experimental autoimmune encephalomyelitis (EAE). In this model, macrophages infiltrate the CNS exhibiting tissue-destructing and demyelinating activity, leading to MS-like symptoms. We show here that severity of EAE symptoms is reduced in Sn knockout (KO) mice compared with wild-type littermates due to an up-regulation of CD4+Foxp3+ Treg lymphocytes. Through the use of a Sn fusion protein, Tregs were shown to express substantial amounts of Sn ligand on their cell surface, and direct interaction of Sn+ macrophages with Tregs specifically inhibited Treg but not effector T lymphocyte proliferation. Conversely, blocking of Sn on macrophages by Sn-specific Abs resulted in elevated proliferation of Tregs. Data indicate that Sn+ macrophages regulate Treg homeostasis which subsequently influences EAE progression. We propose a new direct cell-cell interaction-based mechanism regulating the expansion of the Tregs during the immune response, representing a “dialogue” between Sn+ macrophages and Sn-accessible sialic acid residues on Treg lymphocytes." @default.
• W1900528944 created "2016-06-24" @default.
• W1900528944 creator A5028741978 @default.
• W1900528944 creator A5031189214 @default.
• W1900528944 creator A5031719922 @default.
• W1900528944 creator A5045347734 @default.
• W1900528944 creator A5052160547 @default.
• W1900528944 creator A5072230399 @default.
• W1900528944 creator A5088206488 @default.
• W1900528944 date "2009-05-15" @default.
• W1900528944 modified "2023-10-17" @default.
• W1900528944 title "Sialoadhesin-Positive Macrophages Bind Regulatory T Cells, Negatively Controlling Their Expansion and Autoimmune Disease Progression" @default.
• W1900528944 cites W1560865892 @default.
• W1900528944 cites W1589864226 @default.
• W1900528944 cites W1609881762 @default.
• W1900528944 cites W1641259203 @default.
• W1900528944 cites W1836588334 @default.
• W1900528944 cites W1971907885 @default.
• W1900528944 cites W1973395156 @default.
• W1900528944 cites W1977012724 @default.
• W1900528944 cites W1978180376 @default.
• W1900528944 cites W1987259015 @default.
• W1900528944 cites W1994457578 @default.
• W1900528944 cites W1995747351 @default.
• W1900528944 cites W1996087599 @default.
• W1900528944 cites W2004660702 @default.
• W1900528944 cites W2018122406 @default.
• W1900528944 cites W2021603971 @default.
• W1900528944 cites W2026426963 @default.
• W1900528944 cites W2033388004 @default.
• W1900528944 cites W2046361773 @default.
• W1900528944 cites W2053189124 @default.
• W1900528944 cites W2056139144 @default.
• W1900528944 cites W2061071534 @default.
• W1900528944 cites W2064365779 @default.
• W1900528944 cites W2065425492 @default.
• W1900528944 cites W2068639447 @default.
• W1900528944 cites W2069079409 @default.
• W1900528944 cites W2075853683 @default.
• W1900528944 cites W2082828623 @default.
• W1900528944 cites W2088422105 @default.
• W1900528944 cites W2094062606 @default.
• W1900528944 cites W2097276049 @default.
• W1900528944 cites W2100357356 @default.
• W1900528944 cites W2104460754 @default.
• W1900528944 cites W2113647744 @default.
• W1900528944 cites W2116060589 @default.
• W1900528944 cites W2130842098 @default.
• W1900528944 cites W2138278594 @default.
• W1900528944 cites W2139974970 @default.
• W1900528944 cites W2148226248 @default.
• W1900528944 cites W2150224248 @default.
• W1900528944 cites W2152765608 @default.
• W1900528944 cites W2153274751 @default.
• W1900528944 cites W2154793195 @default.
• W1900528944 cites W2155170237 @default.
• W1900528944 cites W2168000735 @default.
• W1900528944 cites W2338102355 @default.
• W1900528944 cites W4239710358 @default.
• W1900528944 doi "https://doi.org/10.4049/jimmunol.0804247" @default.
• W1900528944 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3733067" @default.
• W1900528944 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19414805" @default.
• W1900528944 hasPublicationYear "2009" @default.
• W1900528944 type Work @default.
• W1900528944 sameAs 1900528944 @default.
• W1900528944 citedByCount "76" @default.
• W1900528944 countsByYear W19005289442012 @default.
• W1900528944 countsByYear W19005289442013 @default.
• W1900528944 countsByYear W19005289442014 @default.
• W1900528944 countsByYear W19005289442015 @default.
• W1900528944 countsByYear W19005289442016 @default.
• W1900528944 countsByYear W19005289442017 @default.
• W1900528944 countsByYear W19005289442018 @default.
• W1900528944 countsByYear W19005289442020 @default.
• W1900528944 countsByYear W19005289442021 @default.
• W1900528944 countsByYear W19005289442022 @default.
• W1900528944 countsByYear W19005289442023 @default.
• W1900528944 crossrefType "journal-article" @default.
• W1900528944 hasAuthorship W1900528944A5028741978 @default.
• W1900528944 hasAuthorship W1900528944A5031189214 @default.
• W1900528944 hasAuthorship W1900528944A5031719922 @default.
• W1900528944 hasAuthorship W1900528944A5045347734 @default.
• W1900528944 hasAuthorship W1900528944A5052160547 @default.
• W1900528944 hasAuthorship W1900528944A5072230399 @default.
• W1900528944 hasAuthorship W1900528944A5088206488 @default.
• W1900528944 hasBestOaLocation W19005289441 @default.
• W1900528944 hasConcept C170493617 @default.
• W1900528944 hasConcept C185592680 @default.
• W1900528944 hasConcept C203014093 @default.
• W1900528944 hasConcept C2776090121 @default.
• W1900528944 hasConcept C2778017598 @default.
• W1900528944 hasConcept C2778296632 @default.
• W1900528944 hasConcept C2778486448 @default.
• W1900528944 hasConcept C2779727006 @default.
• W1900528944 hasConcept C51785407 @default.
• W1900528944 hasConcept C55493867 @default.
• W1900528944 hasConcept C79484868 @default.
• W1900528944 hasConcept C86803240 @default.

• next