FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1900529645> ?p ?o ?g. }

• W1900529645 endingPage "6" @default.
• W1900529645 startingPage "2560" @default.
• W1900529645 abstract "This study was undertaken to determine whether in vitro treatment of Lewis lung carcinoma (3LL) cells with ultraviolet (UV) radiation could increase their immunogenicity. Tumor cells were irradiated with UV light from a germicidal lamp (254 nm; UV-C) at a dose of 720 J/sq m. After 2 weeks of culture, the surviving cell population was cloned by limiting dilution. Cell suspensions of each clone were injected intrafootpad in C57BL/6 mice at a dose of 2.5 X 10(5) cells per mouse. Eighty independent clones were tested. Fifty-one clones showed decreased tumorigenicity and failed to grow in 20 to 95% of immunocompetent mice, whereas they produced tumors in 100% of irradiated (550 R) and athymic nude mice. These clones were designated tum- (nontumorigenic) clones. In contrast, all 25 clones selected from the untreated parental 3LL induced progressively growing tumors in 100% of the mice. After two courses of UV treatment, the uncloned 3LL population was rejected in 45% of inoculated mice. Mice rejecting an inoculum of a tum- clone were completely resistant to subsequent challenge with higher doses of the same or unrelated tum- clones. This resistance was fully expressed even after irradiation of immune mice with 550 R. Mice immune to a tum- clone also were able to prevent the growth of various tum+ clones or untreated 3LL tumor cells. When tum- and tum+ clone cells were simultaneously inoculated intrafootpad in opposite legs, rejection of tum- clone resulted also in the prevention of the growth of tum+ clone. Spleen cells of immune mice caused rapid elimination of radiolabeled 3LL tumor cells from the place of their inoculation (intrafootpad) and prevented tumor growth. In an in vitro cytotoxic assay, spleen cells after in vivo and in vitro immunization with tum- clones demonstrated high cytotoxic activity against various tum+ clones and parental 3LL cells, as well as against tum- clones. In addition, parental 3LL tumor cells and tum- cells were similarly able to inhibit cytotoxic activity in the cold target inhibition assay. However, in contrast to tum- cells, 3LL cells were less efficient in in vitro restimulation of cytotoxic activity of immune spleen cells. Therefore, these data suggest that tum-, tum+, and parental 3LL cells share a common antigenic specificity, which is not immunogenic in 3LL cells. UV treatment presumably converted the antigenic determinants present in the 3LL cells into an immunogenic form." @default.
• W1900529645 created "2016-06-24" @default.
• W1900529645 creator A5021726801 @default.
• W1900529645 creator A5042253522 @default.
• W1900529645 creator A5077055542 @default.
• W1900529645 date "1985-06-01" @default.
• W1900529645 modified "2023-09-23" @default.
• W1900529645 title "Induction of highly immunogenic variants of Lewis lung carcinoma tumor by ultraviolet irradiation." @default.
• W1900529645 cites W1436001149 @default.
• W1900529645 cites W1518861232 @default.
• W1900529645 cites W1801100585 @default.
• W1900529645 cites W1891234789 @default.
• W1900529645 cites W1973032913 @default.
• W1900529645 cites W1976609830 @default.
• W1900529645 cites W1977252286 @default.
• W1900529645 cites W1981957093 @default.
• W1900529645 cites W1990664737 @default.
• W1900529645 cites W1997862640 @default.
• W1900529645 cites W2005139556 @default.
• W1900529645 cites W2006299604 @default.
• W1900529645 cites W2009209888 @default.
• W1900529645 cites W2011120959 @default.
• W1900529645 cites W2014275994 @default.
• W1900529645 cites W2017595171 @default.
• W1900529645 cites W2019980723 @default.
• W1900529645 cites W2032209510 @default.
• W1900529645 cites W2045006830 @default.
• W1900529645 cites W2045411834 @default.
• W1900529645 cites W2050830470 @default.
• W1900529645 cites W2054750039 @default.
• W1900529645 cites W206692983 @default.
• W1900529645 cites W2091602444 @default.
• W1900529645 cites W2094371923 @default.
• W1900529645 cites W2103069179 @default.
• W1900529645 cites W2107910767 @default.
• W1900529645 cites W2111970653 @default.
• W1900529645 cites W2135760279 @default.
• W1900529645 cites W2140908643 @default.
• W1900529645 cites W2161493114 @default.
• W1900529645 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2580624" @default.
• W1900529645 hasPublicationYear "1985" @default.
• W1900529645 type Work @default.
• W1900529645 sameAs 1900529645 @default.
• W1900529645 citedByCount "16" @default.
• W1900529645 countsByYear W19005296452017 @default.
• W1900529645 countsByYear W19005296452018 @default.
• W1900529645 crossrefType "journal-article" @default.
• W1900529645 hasAuthorship W1900529645A5021726801 @default.
• W1900529645 hasAuthorship W1900529645A5042253522 @default.
• W1900529645 hasAuthorship W1900529645A5077055542 @default.
• W1900529645 hasConcept C121608353 @default.
• W1900529645 hasConcept C126322002 @default.
• W1900529645 hasConcept C153911025 @default.
• W1900529645 hasConcept C159047783 @default.
• W1900529645 hasConcept C180032290 @default.
• W1900529645 hasConcept C203014093 @default.
• W1900529645 hasConcept C206684579 @default.
• W1900529645 hasConcept C2777847059 @default.
• W1900529645 hasConcept C2779013556 @default.
• W1900529645 hasConcept C2780868878 @default.
• W1900529645 hasConcept C2780931953 @default.
• W1900529645 hasConcept C2908647359 @default.
• W1900529645 hasConcept C509974204 @default.
• W1900529645 hasConcept C54355233 @default.
• W1900529645 hasConcept C552990157 @default.
• W1900529645 hasConcept C71924100 @default.
• W1900529645 hasConcept C81089528 @default.
• W1900529645 hasConcept C81885089 @default.
• W1900529645 hasConcept C86803240 @default.
• W1900529645 hasConcept C8891405 @default.
• W1900529645 hasConcept C99454951 @default.
• W1900529645 hasConceptScore W1900529645C121608353 @default.
• W1900529645 hasConceptScore W1900529645C126322002 @default.
• W1900529645 hasConceptScore W1900529645C153911025 @default.
• W1900529645 hasConceptScore W1900529645C159047783 @default.
• W1900529645 hasConceptScore W1900529645C180032290 @default.
• W1900529645 hasConceptScore W1900529645C203014093 @default.
• W1900529645 hasConceptScore W1900529645C206684579 @default.
• W1900529645 hasConceptScore W1900529645C2777847059 @default.
• W1900529645 hasConceptScore W1900529645C2779013556 @default.
• W1900529645 hasConceptScore W1900529645C2780868878 @default.
• W1900529645 hasConceptScore W1900529645C2780931953 @default.
• W1900529645 hasConceptScore W1900529645C2908647359 @default.
• W1900529645 hasConceptScore W1900529645C509974204 @default.
• W1900529645 hasConceptScore W1900529645C54355233 @default.
• W1900529645 hasConceptScore W1900529645C552990157 @default.
• W1900529645 hasConceptScore W1900529645C71924100 @default.
• W1900529645 hasConceptScore W1900529645C81089528 @default.
• W1900529645 hasConceptScore W1900529645C81885089 @default.
• W1900529645 hasConceptScore W1900529645C86803240 @default.
• W1900529645 hasConceptScore W1900529645C8891405 @default.
• W1900529645 hasConceptScore W1900529645C99454951 @default.
• W1900529645 hasIssue "6" @default.
• W1900529645 hasLocation W19005296451 @default.
• W1900529645 hasOpenAccess W1900529645 @default.
• W1900529645 hasPrimaryLocation W19005296451 @default.
• W1900529645 hasRelatedWork W1487857142 @default.
• W1900529645 hasRelatedWork W1967488373 @default.

• next