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• W1900535849 abstract "Glial cell line-derived neurotrophic factor (GDNF) injected intranigrally protects midbrain dopamine neurons against 6-hydroxydopamine (6-OHDA) toxicity. The timing between GDNF administration and exposure to 6-OHDA is critical in achieving optimal protection. When injected 6 hr before an intranigral injection of 6-OHDA, GDNF provides complete protection as measured by the number of surviving neurons in the substantia nigra of adult rats. The surviving neuronal population decreases by ∼50% with 12 and 24 hr separating GDNF and 6-OHDA administrations. In controls with 6-OHDA lesions, there is <10% survival of nigral dopamine neurons. No significant increase in survival is seen with either concurrent injections of GDNF and 6-OHDA or 1 hr GDNF pretreatment. Based on HPLC measurements, striatal and midbrain dopamine levels are at least twofold higher on the lesioned side in animals receiving GDNF 6 hr before a 6-OHDA lesion compared with vehicle recipients. Protein synthesis is necessary for GDNF-induced neuroprotective effects because cycloheximide pretreatment that inhibits protein synthesis also blocks neuroprotection." @default.
• W1900535849 created "2016-06-24" @default.
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• W1900535849 date "1997-09-15" @default.
• W1900535849 modified "2023-10-16" @default.
• W1900535849 title "GDNF Protection against 6-OHDA: Time Dependence and Requirement for Protein Synthesis" @default.
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• W1900535849 doi "https://doi.org/10.1523/jneurosci.17-18-07111.1997" @default.
• W1900535849 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6573260" @default.
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