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- W1900540629 abstract "Metformin is an oral anti-hyperglycemic drug that acts as an insulin sensitizer in the treatment of diabetes mellitus type 2. It has also been widely used in the treatment of polycystic ovary syndrome (PCOS) and gestational diabetes. This drug has been shown to activate a protein kinase called 5' AMP-activated protein kinase or AMPK. AMPK is present in many tissues making metformin's effect multi factorial. However as metformin crosses the placenta, its use during pregnancy raises concerns regarding potential adverse effects on the mother and fetus. The majority of reports suggest no significant adverse effects or teratogenicity. However, disconcerting reports of male mouse offspring that were exposed to metformin in utero that present with a reduction in testis size, seminiferous tubule size and in Sertoli cell number suggest that we do not understand the full suite of effects of metformin. In addition, recent molecular evidence is suggesting an epigenetic effect of metformin which could explain some of the long-term effects reported. Nevertheless, the data are still insufficient to completely confirm or disprove negative effects of metformin. The aims of this review are to provide a summary of the safety of metformin in various aspects of sexual reproduction, the use of metformin by gestating mothers, and its possible side-effects on offspring from women who are administered metformin during pregnancy." @default.
- W1900540629 created "2016-06-24" @default.
- W1900540629 creator A5003855009 @default.
- W1900540629 creator A5019430879 @default.
- W1900540629 creator A5047353371 @default.
- W1900540629 creator A5091539631 @default.
- W1900540629 date "2014-06-01" @default.
- W1900540629 modified "2023-10-17" @default.
- W1900540629 title "Impact of metformin on reproductive tissues: an overview from gametogenesis to gestation." @default.
- W1900540629 cites W1486665559 @default.
- W1900540629 cites W1558951658 @default.
- W1900540629 cites W1561278284 @default.
- W1900540629 cites W157601390 @default.
- W1900540629 cites W196333671 @default.
- W1900540629 cites W1967251674 @default.
- W1900540629 cites W1971774965 @default.
- W1900540629 cites W1973300372 @default.
- W1900540629 cites W1974497344 @default.
- W1900540629 cites W1976186693 @default.
- W1900540629 cites W1979876574 @default.
- W1900540629 cites W1985141616 @default.
- W1900540629 cites W1987175958 @default.
- W1900540629 cites W1987181224 @default.
- W1900540629 cites W1993302692 @default.
- W1900540629 cites W1994554353 @default.
- W1900540629 cites W1995069275 @default.
- W1900540629 cites W1995501935 @default.
- W1900540629 cites W1996531503 @default.
- W1900540629 cites W1997003352 @default.
- W1900540629 cites W1998771362 @default.
- W1900540629 cites W2001340600 @default.
- W1900540629 cites W2002958599 @default.
- W1900540629 cites W2003374029 @default.
- W1900540629 cites W2003621575 @default.
- W1900540629 cites W2004341421 @default.
- W1900540629 cites W2004888991 @default.
- W1900540629 cites W2005264045 @default.
- W1900540629 cites W2005985653 @default.
- W1900540629 cites W2006426761 @default.
- W1900540629 cites W2007725717 @default.
- W1900540629 cites W2011641553 @default.
- W1900540629 cites W2013374433 @default.
- W1900540629 cites W2013700032 @default.
- W1900540629 cites W2014046105 @default.
- W1900540629 cites W2014920715 @default.
- W1900540629 cites W2015228428 @default.
- W1900540629 cites W2017470589 @default.
- W1900540629 cites W2024325406 @default.
- W1900540629 cites W2025373081 @default.
- W1900540629 cites W2025413292 @default.
- W1900540629 cites W2025446322 @default.
- W1900540629 cites W2025931208 @default.
- W1900540629 cites W2026099958 @default.
- W1900540629 cites W2026300863 @default.
- W1900540629 cites W2029110614 @default.
- W1900540629 cites W2035069455 @default.
- W1900540629 cites W2035703541 @default.
- W1900540629 cites W2035905369 @default.
- W1900540629 cites W2037197751 @default.
- W1900540629 cites W2041615082 @default.
- W1900540629 cites W2042103664 @default.
- W1900540629 cites W2048527301 @default.
- W1900540629 cites W2051272157 @default.
- W1900540629 cites W2051448662 @default.
- W1900540629 cites W2053488780 @default.
- W1900540629 cites W2063226778 @default.
- W1900540629 cites W2065824050 @default.
- W1900540629 cites W2068324526 @default.
- W1900540629 cites W2070069669 @default.
- W1900540629 cites W2072474124 @default.
- W1900540629 cites W2074265099 @default.
- W1900540629 cites W2074303577 @default.
- W1900540629 cites W2074307717 @default.
- W1900540629 cites W2076148412 @default.
- W1900540629 cites W2076169228 @default.
- W1900540629 cites W2078184154 @default.
- W1900540629 cites W2080231032 @default.
- W1900540629 cites W2083992262 @default.
- W1900540629 cites W2090047695 @default.
- W1900540629 cites W2091394680 @default.
- W1900540629 cites W2091519032 @default.
- W1900540629 cites W2092340120 @default.
- W1900540629 cites W2095852400 @default.
- W1900540629 cites W2096591765 @default.
- W1900540629 cites W2098595011 @default.
- W1900540629 cites W2100211815 @default.
- W1900540629 cites W2102307174 @default.
- W1900540629 cites W2102986036 @default.
- W1900540629 cites W2107580391 @default.
- W1900540629 cites W2107680033 @default.
- W1900540629 cites W2110145701 @default.
- W1900540629 cites W2110651221 @default.
- W1900540629 cites W2111331236 @default.
- W1900540629 cites W2113909175 @default.
- W1900540629 cites W2117086890 @default.
- W1900540629 cites W2117371839 @default.
- W1900540629 cites W2117486744 @default.
- W1900540629 cites W2123925343 @default.
- W1900540629 cites W2124365162 @default.
- W1900540629 cites W2124760769 @default.