FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1900547505> ?p ?o ?g. }

• W1900547505 endingPage "441" @default.
• W1900547505 startingPage "431" @default.
• W1900547505 abstract "Ratajczak-Wrona W, Jablonska E, Garley M, Jablonski J, Radziwon P. Effect of N-nitrosodimethylamine on inducible nitric oxide synthase expression and production of nitric oxide by neutrophils and mononuclear cells: the role of JNK signalling pathway, APMIS 2011; 119: 431–41. In neutrophils (PMN) and mononuclear cells (PBMC), one of the enzymes responsible for nitric oxide (NO) synthesis is inducible nitric oxide synthase (iNOS). Changes in iNOS expression result from various signalling pathways including the mitogen-activated protein kinase (MAPK) pathway activated by endogenic and exogenic factors. N-nitrosodimethylamine (NDMA) is a xenobiotic with widespread occurrence in human environment and has an effect on cells of the immune system. The aim of this study was to determine the effect of NDMA on iNOS expression and NO production by human PMN and PBMC cells in the light of superoxide anion production by PMN cells. Moreover, the role of JNK and p38 pathways in NO production with involvement of iNOS was studied. Additionally, the function of JNK pathway in generation of superoxide anion was determined. Moreover, nitrotyrosine expression was studied in PMN and PBMC cells in the presence of NDMA. This work shows that NDMA increases iNOS expression and NO production by PMN and PBMC cells. In addition, elevated expression of phospho-JNK and phospho-p38, which are markers of JNK and p38 MAPK pathways activation, were observed. Lower iNOS expression and NO production by neutrophils exposed to extended action of NDMA were observed after application of inhibitor of JNK and p38 pathways. Lower phospho-p38 expression in PMN stimulated by NDMA was found as a result of arresting JNK pathway, whereas, application of inhibitor of p38 pathway resulted in enhanced phospho-JNK expression in PMN and PBMC cells. Increased ability to release superoxide anion by NDMA-stimulated PMN cells was observed. This ability was reduced after the application of inhibitor of JNK pathway. In PMN and PBMC cells exposed to NDMA, an increased expression of nitrotyrosine, which is dependant on JNK and p38 pathways that are activated by this particular xenobiotic, was observed. Generally, increased induction of iNOS related to elevated production of NO by PMN and PBMC cells exposed to NDMA may result in dysfunction of regulation of immunity responses controlled by this molecule in various conditions. Increased expression of nitrotyrosine in PMN and PBMC cells exposed to NDMA may affect their functions in an auto- and/or a paracrine way. Mutual interactions of JNK and p38 MAPK during the induction of iNOS expression in cells exposed to NDMA indicate complex mechanism of induction of iNOS synthase." @default.
• W1900547505 created "2016-06-24" @default.
• W1900547505 creator A5034271393 @default.
• W1900547505 creator A5049723469 @default.
• W1900547505 creator A5055272591 @default.
• W1900547505 creator A5062932374 @default.
• W1900547505 creator A5064855369 @default.
• W1900547505 date "2011-04-25" @default.
• W1900547505 modified "2023-09-24" @default.
• W1900547505 title "Effect of N-nitrosodimethylamine on inducible nitric oxide synthase expression and production of nitric oxide by neutrophils and mononuclear cells: the role of JNK signalling pathway" @default.
• W1900547505 cites W1572174728 @default.
• W1900547505 cites W1852641270 @default.
• W1900547505 cites W1967270772 @default.
• W1900547505 cites W1974358158 @default.
• W1900547505 cites W2007850477 @default.
• W1900547505 cites W2009009748 @default.
• W1900547505 cites W2017645161 @default.
• W1900547505 cites W2019752563 @default.
• W1900547505 cites W2024727248 @default.
• W1900547505 cites W2034919439 @default.
• W1900547505 cites W2044800103 @default.
• W1900547505 cites W2045429393 @default.
• W1900547505 cites W2050348658 @default.
• W1900547505 cites W2054116154 @default.
• W1900547505 cites W2056671431 @default.
• W1900547505 cites W2069598912 @default.
• W1900547505 cites W2081398117 @default.
• W1900547505 cites W2093534424 @default.
• W1900547505 cites W2096931514 @default.
• W1900547505 cites W2104676167 @default.
• W1900547505 cites W2111300036 @default.
• W1900547505 cites W2122986470 @default.
• W1900547505 cites W2134709015 @default.
• W1900547505 cites W2155495415 @default.
• W1900547505 cites W2157579772 @default.
• W1900547505 cites W2164516260 @default.
• W1900547505 cites W2408912917 @default.
• W1900547505 cites W4244655143 @default.
• W1900547505 cites W4251313623 @default.
• W1900547505 doi "https://doi.org/10.1111/j.1600-0463.2011.02750.x" @default.
• W1900547505 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21635550" @default.
• W1900547505 hasPublicationYear "2011" @default.
• W1900547505 type Work @default.
• W1900547505 sameAs 1900547505 @default.
• W1900547505 citedByCount "10" @default.
• W1900547505 countsByYear W19005475052012 @default.
• W1900547505 countsByYear W19005475052013 @default.
• W1900547505 countsByYear W19005475052017 @default.
• W1900547505 countsByYear W19005475052018 @default.
• W1900547505 crossrefType "journal-article" @default.
• W1900547505 hasAuthorship W1900547505A5034271393 @default.
• W1900547505 hasAuthorship W1900547505A5049723469 @default.
• W1900547505 hasAuthorship W1900547505A5055272591 @default.
• W1900547505 hasAuthorship W1900547505A5062932374 @default.
• W1900547505 hasAuthorship W1900547505A5064855369 @default.
• W1900547505 hasConcept C114246631 @default.
• W1900547505 hasConcept C137061746 @default.
• W1900547505 hasConcept C153911025 @default.
• W1900547505 hasConcept C178790620 @default.
• W1900547505 hasConcept C181199279 @default.
• W1900547505 hasConcept C185592680 @default.
• W1900547505 hasConcept C202751555 @default.
• W1900547505 hasConcept C2777622882 @default.
• W1900547505 hasConcept C2780750100 @default.
• W1900547505 hasConcept C2780795997 @default.
• W1900547505 hasConcept C51551487 @default.
• W1900547505 hasConcept C519581460 @default.
• W1900547505 hasConcept C55493867 @default.
• W1900547505 hasConcept C57074206 @default.
• W1900547505 hasConcept C62478195 @default.
• W1900547505 hasConcept C86803240 @default.
• W1900547505 hasConcept C95444343 @default.
• W1900547505 hasConceptScore W1900547505C114246631 @default.
• W1900547505 hasConceptScore W1900547505C137061746 @default.
• W1900547505 hasConceptScore W1900547505C153911025 @default.
• W1900547505 hasConceptScore W1900547505C178790620 @default.
• W1900547505 hasConceptScore W1900547505C181199279 @default.
• W1900547505 hasConceptScore W1900547505C185592680 @default.
• W1900547505 hasConceptScore W1900547505C202751555 @default.
• W1900547505 hasConceptScore W1900547505C2777622882 @default.
• W1900547505 hasConceptScore W1900547505C2780750100 @default.
• W1900547505 hasConceptScore W1900547505C2780795997 @default.
• W1900547505 hasConceptScore W1900547505C51551487 @default.
• W1900547505 hasConceptScore W1900547505C519581460 @default.
• W1900547505 hasConceptScore W1900547505C55493867 @default.
• W1900547505 hasConceptScore W1900547505C57074206 @default.
• W1900547505 hasConceptScore W1900547505C62478195 @default.
• W1900547505 hasConceptScore W1900547505C86803240 @default.
• W1900547505 hasConceptScore W1900547505C95444343 @default.
• W1900547505 hasIssue "7" @default.
• W1900547505 hasLocation W19005475051 @default.
• W1900547505 hasLocation W19005475052 @default.
• W1900547505 hasOpenAccess W1900547505 @default.
• W1900547505 hasPrimaryLocation W19005475051 @default.
• W1900547505 hasRelatedWork W1971316357 @default.
• W1900547505 hasRelatedWork W1985272877 @default.
• W1900547505 hasRelatedWork W1995926003 @default.
• W1900547505 hasRelatedWork W2004726042 @default.

• next