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• W1900556985 abstract "eth-1r a thermosensitive allele of the Neurospora crassa S-adenosylmethionine (AdoMet) synthetase gene that confers ethionine resistance, has been cloned and sequenced. Replacement of an aspartic amino acid residue (D48 → N48), perfectly conserved in prokaryotic, fungal and higher eukaryotic AdoMet synthetases, was found responsible for both thermosensitivity and ethionine resistance conferred by eth-1r. Gene fusion constructs, designed to overexpress eth-1r in vivo, render transformant cells resistant to ethionine. Dominance of ethionine resistance was further demonstrated in eth-1 +/eth-1r partial diploids carrying identical gene doses of both alleles. Heterozygous eth-1 +/eth-1r cells have, at the same time, both the thermotolerance conferred by eth-1 + and the ethionine-resistant phenotype conferred by eth-1r. AdoMet levels and AdoMet synthetase activities were dramatically decreased in heterozygous eth-1 +/eth-1r cells. We propose that this negative effect exerted by eth-1r results from the in vivo formation of heteromeric eth-1 +/eth-1r AdoMet synthetase molecules." @default.
• W1900556985 created "2016-06-24" @default.
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• W1900556985 date "1996-12-01" @default.
• W1900556985 modified "2023-09-27" @default.
• W1900556985 title "A Dominant Negative Effect of <i>eth-1r</i>, a Mutant Allele of the <i>Neurospora crassa</i> S-Adenosylmethionine Synthetase-Encoding Gene Conferring Resistance to the Methionine Toxic Analogue Ethionine" @default.
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• W1900556985 doi "https://doi.org/10.1093/genetics/144.4.1455" @default.
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