FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W190056571> ?p ?o ?g. }

• W190056571 endingPage "12" @default.
• W190056571 startingPage "507" @default.
• W190056571 abstract "CD59 is a widely expressed cell surface glycosylphosphatidylinositol (GPI)-linked glycoprotein which acts as an inhibitor of the assembly of the membrane attack complex of autologous complement. Four new monoclonal antibodies to CD59 (2/24, 1B2, BRIC 229, BRIC 257) are described. Competitive binding experiments using these antibodies, two known CD59 antibodies (MEM-43, YTH 53.1) and a previously described antibody LICR-LON-Fib75.1 demonstrated that all seven antibodies see related epitopes on human erythrocyte CD59. In common with other GPI-linked proteins, CD59 (as defined by antibody 2/24) was sensitive to treatment with phosphatidylinositol-specific phospholipase C (PI-PLC) on lymphocytes and monocytes but not on erythrocytes. Flow cytometric analysis using antibody 2/24 identified two populations (CD59 positive and CD59 deficient) of lymphocytes, monocytes and erythrocytes in peripheral blood from a patient with paroxysmal nocturnal haemoglobinuria (PNH). The abundance of CD59 on normal erythrocytes was determined as 21,000 copies/cell when radioiodinated BRIC 229 was used. Other CD59 antibodies gave values of 10,000 (IF5) and 15,000 (2/24) against the same target cells. Radioiodinated Fab fragments of BRIC 229 gave a value of 39,000 copies/cell. Erythrocytes from two individuals with a rare inherited deficiency of decay accelerating factor (DAF), known as the Inab phenotype, expressed normal levels of CD59." @default.
• W190056571 created "2016-06-24" @default.
• W190056571 creator A5006013394 @default.
• W190056571 creator A5006251674 @default.
• W190056571 creator A5010112964 @default.
• W190056571 creator A5025016046 @default.
• W190056571 creator A5025732981 @default.
• W190056571 creator A5032995392 @default.
• W190056571 creator A5070227722 @default.
• W190056571 creator A5088613398 @default.
• W190056571 date "1992-03-01" @default.
• W190056571 modified "2023-09-27" @default.
• W190056571 title "New monoclonal antibodies in CD59: use for the analysis of peripheral blood cells from paroxysmal nocturnal haemoglobinuria (PNH) patients and for the quantitation of CD59 on normal and decay accelerating factor (DAF)-deficient erythrocytes." @default.
• W190056571 cites W139415312 @default.
• W190056571 cites W1481229608 @default.
• W190056571 cites W1499382446 @default.
• W190056571 cites W1505628503 @default.
• W190056571 cites W1543999675 @default.
• W190056571 cites W1549227663 @default.
• W190056571 cites W1563419652 @default.
• W190056571 cites W166670258 @default.
• W190056571 cites W171492611 @default.
• W190056571 cites W1968050622 @default.
• W190056571 cites W1973143771 @default.
• W190056571 cites W1975494783 @default.
• W190056571 cites W1979483121 @default.
• W190056571 cites W2001664656 @default.
• W190056571 cites W2008635302 @default.
• W190056571 cites W2018289835 @default.
• W190056571 cites W2037578169 @default.
• W190056571 cites W2041110206 @default.
• W190056571 cites W2050743880 @default.
• W190056571 cites W2052664734 @default.
• W190056571 cites W2055451611 @default.
• W190056571 cites W2059547846 @default.
• W190056571 cites W2082156530 @default.
• W190056571 cites W2099822544 @default.
• W190056571 cites W2100837269 @default.
• W190056571 cites W2151534309 @default.
• W190056571 cites W2152506674 @default.
• W190056571 cites W2178334364 @default.
• W190056571 cites W2247449597 @default.
• W190056571 cites W2323202050 @default.
• W190056571 cites W2338379496 @default.
• W190056571 cites W2344572171 @default.
• W190056571 cites W2395465626 @default.
• W190056571 cites W2415627551 @default.
• W190056571 cites W258142333 @default.
• W190056571 cites W301210341 @default.
• W190056571 cites W93191664 @default.
• W190056571 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1384747" @default.
• W190056571 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1374058" @default.
• W190056571 hasPublicationYear "1992" @default.
• W190056571 type Work @default.
• W190056571 sameAs 190056571 @default.
• W190056571 citedByCount "20" @default.
• W190056571 countsByYear W1900565712012 @default.
• W190056571 countsByYear W1900565712015 @default.
• W190056571 crossrefType "journal-article" @default.
• W190056571 hasAuthorship W190056571A5006013394 @default.
• W190056571 hasAuthorship W190056571A5006251674 @default.
• W190056571 hasAuthorship W190056571A5010112964 @default.
• W190056571 hasAuthorship W190056571A5025016046 @default.
• W190056571 hasAuthorship W190056571A5025732981 @default.
• W190056571 hasAuthorship W190056571A5032995392 @default.
• W190056571 hasAuthorship W190056571A5070227722 @default.
• W190056571 hasAuthorship W190056571A5088613398 @default.
• W190056571 hasConcept C108625454 @default.
• W190056571 hasConcept C111684460 @default.
• W190056571 hasConcept C153911025 @default.
• W190056571 hasConcept C159654299 @default.
• W190056571 hasConcept C184404459 @default.
• W190056571 hasConcept C185592680 @default.
• W190056571 hasConcept C195616568 @default.
• W190056571 hasConcept C203014093 @default.
• W190056571 hasConcept C542903549 @default.
• W190056571 hasConcept C8487232 @default.
• W190056571 hasConcept C86803240 @default.
• W190056571 hasConceptScore W190056571C108625454 @default.
• W190056571 hasConceptScore W190056571C111684460 @default.
• W190056571 hasConceptScore W190056571C153911025 @default.
• W190056571 hasConceptScore W190056571C159654299 @default.
• W190056571 hasConceptScore W190056571C184404459 @default.
• W190056571 hasConceptScore W190056571C185592680 @default.
• W190056571 hasConceptScore W190056571C195616568 @default.
• W190056571 hasConceptScore W190056571C203014093 @default.
• W190056571 hasConceptScore W190056571C542903549 @default.
• W190056571 hasConceptScore W190056571C8487232 @default.
• W190056571 hasConceptScore W190056571C86803240 @default.
• W190056571 hasIssue "3" @default.
• W190056571 hasLocation W1900565711 @default.
• W190056571 hasOpenAccess W190056571 @default.
• W190056571 hasPrimaryLocation W1900565711 @default.
• W190056571 hasRelatedWork W190056571 @default.
• W190056571 hasRelatedWork W1987801792 @default.
• W190056571 hasRelatedWork W1988571013 @default.
• W190056571 hasRelatedWork W2006285358 @default.
• W190056571 hasRelatedWork W2043682520 @default.

• next