FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1900567827> ?p ?o ?g. }

• W1900567827 abstract "Preterm birth, defined as birth before 37 completed weeks, is the single most important cause of perinatal mortality and morbidity in high-income countries. Oxytocin receptor antagonists have been proposed as effective tocolytic agents for women in preterm labour to postpone the birth, with fewer side-effects than other tocolytic agents.To assess the effects on maternal, fetal and neonatal outcomes of tocolysis with oxytocin receptor antagonists for women with preterm labour compared with placebo or no intervention and compared with any other tocolytic agent.We searched the Cochrane Pregnancy and Childbirth Group's Trials Register (September 2004), CENTRAL (The Cochrane Library, Issue 3, 2004), MEDLINE (1965 to June 2004), EMBASE (1988 to June 2004).Randomised trials of oxytocin receptor antagonists for tocolysis in the management of women in labour between 20 and 36 weeks' gestation.Two authors independently evaluated methodological quality and extracted trial data. We sought additional information from trial authors.Six trials (1695 women) were included. Compared with placebo, atosiban did not reduce incidence of preterm birth or improve neonatal outcome. In one trial (583 infants), atosiban was associated with an increase in infant deaths at 12 months of age compared with placebo (relative risk (RR) 6.15; 95% confidence intervals (CI) 1.39 to 27.22). However, this trial randomised significantly more women to atosiban before 26 weeks' gestation. Use of atosiban resulted in lower infant birthweight (weighted mean difference -138.31 gm; 95% CI -248.76 to -27.86) and more maternal adverse drug reactions (RR 4.02; 95% CI 2.05 to 7.85, 2 trials, 613 women).Compared with betamimetics, atosiban increased the numbers of infants born under 1500 gm (RR 1.96; 95% CI 1.15 to 3.35, 2 trials, 575 infants). Atosiban was associated with fewer maternal drug reactions requiring treatment cessation (RR 0.04; 95% CI 0.02 to 0.11, number needed to treat 6; 95% CI 5 to 7, 4 trials, 1035 women).This review failed to demonstrate the superiority of atosiban over betamimetics or placebo in terms of tocolytic efficacy or infant outcomes. The finding of an increase in infant deaths in one placebo controlled trial warrants caution. A recent Cochrane review suggests that calcium channel blockers (mainly nifedipine) are associated with better neonatal outcome and fewer maternal side-effects than betamimetics. However, a randomised comparison of nifedipine with placebo is not available. Further well-designed randomised controlled trials of tocolytic therapy are needed. Such trials should incorporate a placebo arm." @default.
• W1900567827 created "2016-06-24" @default.
• W1900567827 creator A5005071014 @default.
• W1900567827 creator A5006553059 @default.
• W1900567827 creator A5066704966 @default.
• W1900567827 creator A5084227679 @default.
• W1900567827 date "2005-07-20" @default.
• W1900567827 modified "2023-10-11" @default.
• W1900567827 title "Oxytocin receptor antagonists for inhibiting preterm labour" @default.
• W1900567827 cites W1900567827 @default.
• W1900567827 cites W1932202182 @default.
• W1900567827 cites W1949591994 @default.
• W1900567827 cites W1968620373 @default.
• W1900567827 cites W1970478529 @default.
• W1900567827 cites W1972473783 @default.
• W1900567827 cites W1975489317 @default.
• W1900567827 cites W1976930270 @default.
• W1900567827 cites W1985025059 @default.
• W1900567827 cites W1987025848 @default.
• W1900567827 cites W1992969806 @default.
• W1900567827 cites W2000399626 @default.
• W1900567827 cites W2004773742 @default.
• W1900567827 cites W2010173781 @default.
• W1900567827 cites W2016274463 @default.
• W1900567827 cites W2019896579 @default.
• W1900567827 cites W2023950153 @default.
• W1900567827 cites W2025315474 @default.
• W1900567827 cites W2037143193 @default.
• W1900567827 cites W2040237541 @default.
• W1900567827 cites W2040696336 @default.
• W1900567827 cites W2046451219 @default.
• W1900567827 cites W2047078530 @default.
• W1900567827 cites W2052698374 @default.
• W1900567827 cites W2067381940 @default.
• W1900567827 cites W2071096462 @default.
• W1900567827 cites W2075316646 @default.
• W1900567827 cites W2077492298 @default.
• W1900567827 cites W2080017495 @default.
• W1900567827 cites W2081763798 @default.
• W1900567827 cites W2081889241 @default.
• W1900567827 cites W2088165014 @default.
• W1900567827 cites W2093269059 @default.
• W1900567827 cites W2105827140 @default.
• W1900567827 cites W2126930838 @default.
• W1900567827 cites W2137134913 @default.
• W1900567827 cites W2150139527 @default.
• W1900567827 cites W2153454055 @default.
• W1900567827 cites W2153952360 @default.
• W1900567827 cites W2170489836 @default.
• W1900567827 cites W2171116358 @default.
• W1900567827 cites W2243749545 @default.
• W1900567827 cites W2275290176 @default.
• W1900567827 cites W2319887059 @default.
• W1900567827 cites W2411199035 @default.
• W1900567827 cites W2416403330 @default.
• W1900567827 cites W2806452224 @default.
• W1900567827 cites W4211073485 @default.
• W1900567827 cites W4244435675 @default.
• W1900567827 cites W4252623086 @default.
• W1900567827 cites W4253103833 @default.
• W1900567827 cites W4254592923 @default.
• W1900567827 doi "https://doi.org/10.1002/14651858.cd004452.pub2" @default.
• W1900567827 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24903678" @default.
• W1900567827 hasPublicationYear "2005" @default.
• W1900567827 type Work @default.
• W1900567827 sameAs 1900567827 @default.
• W1900567827 citedByCount "139" @default.
• W1900567827 countsByYear W19005678272012 @default.
• W1900567827 countsByYear W19005678272013 @default.
• W1900567827 countsByYear W19005678272014 @default.
• W1900567827 countsByYear W19005678272015 @default.
• W1900567827 countsByYear W19005678272016 @default.
• W1900567827 countsByYear W19005678272017 @default.
• W1900567827 countsByYear W19005678272018 @default.
• W1900567827 countsByYear W19005678272019 @default.
• W1900567827 countsByYear W19005678272020 @default.
• W1900567827 countsByYear W19005678272021 @default.
• W1900567827 countsByYear W19005678272022 @default.
• W1900567827 countsByYear W19005678272023 @default.
• W1900567827 crossrefType "reference-entry" @default.
• W1900567827 hasAuthorship W1900567827A5005071014 @default.
• W1900567827 hasAuthorship W1900567827A5006553059 @default.
• W1900567827 hasAuthorship W1900567827A5066704966 @default.
• W1900567827 hasAuthorship W1900567827A5084227679 @default.
• W1900567827 hasConcept C126322002 @default.
• W1900567827 hasConcept C131872663 @default.
• W1900567827 hasConcept C142724271 @default.
• W1900567827 hasConcept C168563851 @default.
• W1900567827 hasConcept C181612422 @default.
• W1900567827 hasConcept C204787440 @default.
• W1900567827 hasConcept C27081682 @default.
• W1900567827 hasConcept C2776176026 @default.
• W1900567827 hasConcept C2776344615 @default.
• W1900567827 hasConcept C2779234561 @default.
• W1900567827 hasConcept C2779703513 @default.
• W1900567827 hasConcept C2908881489 @default.
• W1900567827 hasConcept C3019152611 @default.
• W1900567827 hasConcept C44249647 @default.
• W1900567827 hasConcept C46973012 @default.
• W1900567827 hasConcept C54355233 @default.

• next