Matches in SemOpenAlex for { <https://semopenalex.org/work/W1900568542> ?p ?o ?g. }
Showing items 1 to 66 of
66
with 100 items per page.
- W1900568542 endingPage "380" @default.
- W1900568542 startingPage "369" @default.
- W1900568542 abstract "Among inbred mice from the high-leukemia strain AKR and the low-leukemia strain Af, which in addition represent extremes of resistance and susceptibility, respectively, to polycyclic hydrocarbon-induced skin tumorigenesis, marked cell- and tissue-specific differences were apparent in the capability of aryl hydrocarbon hydroxylase activity to be induced in response to 3-methylcholanthrene (MCA). In Af mice, aryl hydrocarbon hydroxylase was inducible by twofold to severalfold in most tissues examined, except possibly some lymphoreticular organs, e.g., spleen. In AKR mice, however, this enzyme system in liver was relatively resistant to induction by MCA. In contrast, the extrahepatic hydroxylase activity from AKR mice was slightly induced in tissues such as lung, epidermis, and probably lymph nodes. The F1 hybrid mice from genetic crosses between these strains resembled Af mice in susceptibility to the effects of MCA as inducer of hydroxylase activity in most tissues tested, though not to the same degree as the parent inbred strain. Further, these hybrids lack MCA-inducible enzyme in corium cutis under the experimental conditions. Thus the regulation of enzyme induction, in the genetic groups examined, seemed not to reflect simple mendelian genetics. The control and inducible levels of hepatic hydroxylase activity from inbred and hybrid mice were higher in females than in males. The hepatic enzyme system derived from female mice was more active in metabolizing MCA as substrate and in catalyzing the formation of polycyclic hydrocarbon-hepatic cytosol protein complexes. However, a lack of correlation was noted between metabolism of MCA or binding of polycyclic hydrocarbon to cytosol macromolecules and the ability of hepatic hydroxylase activity to be induced in response to MCA." @default.
- W1900568542 created "2016-06-24" @default.
- W1900568542 creator A5000727984 @default.
- W1900568542 creator A5020252813 @default.
- W1900568542 creator A5034000711 @default.
- W1900568542 date "1973-02-01" @default.
- W1900568542 modified "2023-10-15" @default.
- W1900568542 title "Induction of Aryl Hydrocarbon Hydroxylase in Mouse Tissues From a High and Low Cancer Strain and Their F 1 Hybrids 2" @default.
- W1900568542 doi "https://doi.org/10.1093/jnci/50.2.369" @default.
- W1900568542 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/4702111" @default.
- W1900568542 hasPublicationYear "1973" @default.
- W1900568542 type Work @default.
- W1900568542 sameAs 1900568542 @default.
- W1900568542 citedByCount "48" @default.
- W1900568542 crossrefType "journal-article" @default.
- W1900568542 hasAuthorship W1900568542A5000727984 @default.
- W1900568542 hasAuthorship W1900568542A5020252813 @default.
- W1900568542 hasAuthorship W1900568542A5034000711 @default.
- W1900568542 hasConcept C104317684 @default.
- W1900568542 hasConcept C114246631 @default.
- W1900568542 hasConcept C126322002 @default.
- W1900568542 hasConcept C132154277 @default.
- W1900568542 hasConcept C153911025 @default.
- W1900568542 hasConcept C181199279 @default.
- W1900568542 hasConcept C2780303067 @default.
- W1900568542 hasConcept C28212737 @default.
- W1900568542 hasConcept C55493867 @default.
- W1900568542 hasConcept C555283112 @default.
- W1900568542 hasConcept C71924100 @default.
- W1900568542 hasConcept C76725341 @default.
- W1900568542 hasConcept C86803240 @default.
- W1900568542 hasConceptScore W1900568542C104317684 @default.
- W1900568542 hasConceptScore W1900568542C114246631 @default.
- W1900568542 hasConceptScore W1900568542C126322002 @default.
- W1900568542 hasConceptScore W1900568542C132154277 @default.
- W1900568542 hasConceptScore W1900568542C153911025 @default.
- W1900568542 hasConceptScore W1900568542C181199279 @default.
- W1900568542 hasConceptScore W1900568542C2780303067 @default.
- W1900568542 hasConceptScore W1900568542C28212737 @default.
- W1900568542 hasConceptScore W1900568542C55493867 @default.
- W1900568542 hasConceptScore W1900568542C555283112 @default.
- W1900568542 hasConceptScore W1900568542C71924100 @default.
- W1900568542 hasConceptScore W1900568542C76725341 @default.
- W1900568542 hasConceptScore W1900568542C86803240 @default.
- W1900568542 hasIssue "2" @default.
- W1900568542 hasLocation W19005685421 @default.
- W1900568542 hasLocation W19005685422 @default.
- W1900568542 hasOpenAccess W1900568542 @default.
- W1900568542 hasPrimaryLocation W19005685421 @default.
- W1900568542 hasRelatedWork W1141103111 @default.
- W1900568542 hasRelatedWork W1949792042 @default.
- W1900568542 hasRelatedWork W1964208073 @default.
- W1900568542 hasRelatedWork W2007427482 @default.
- W1900568542 hasRelatedWork W2077495931 @default.
- W1900568542 hasRelatedWork W2132877526 @default.
- W1900568542 hasRelatedWork W2332806396 @default.
- W1900568542 hasRelatedWork W2460701630 @default.
- W1900568542 hasRelatedWork W379409117 @default.
- W1900568542 hasRelatedWork W43084090 @default.
- W1900568542 hasVolume "50" @default.
- W1900568542 isParatext "false" @default.
- W1900568542 isRetracted "false" @default.
- W1900568542 magId "1900568542" @default.
- W1900568542 workType "article" @default.