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- W190058637 abstract "The nervous system is a target for steroid hormones as well as a steroidogenic tissue, and it produces steroids that have a paracrine or autocrine effect on neurons and glial cells. Steroids formed in nervous tissue are called neurosteroids in order to differentiate them, in terms of their origin, from the peripheral steroids, although they both share the same molecular structure.We analyse the capacity of neurons and glial cells to synthesise steroids and describe the role played in steroidogenesis by certain key molecules, such as steroidogenic acute regulatory protein, peripheral benzodiazepine receptor and aromatase enzyme, which acts as a catalyst in the conversion of testosterone into estradiol. We also provide a description of the different mechanisms of action of the hormonal steroids and neurosteroids in the nervous system. These include both the regulation of protein synthesis by neurons and glial cells, by acting on nuclear receptors, and rapid effects mediated by membrane receptors or the allosteric modulation of neurotransmitter receptors. We review the clinical and experimental evidence for the neuroprotective effects of sex steroids and neurosteroids, and the limitations of hormone replacement therapy following menopause.Given the restraints involved in the systemic use of hormones as neuroprotective therapy, alternative strategies that take advantage of the neuroprotective properties of steroids must be sought. These could involve locally increasing their synthesis inside the brain or developing molecules that activate the steroid receptors in the nervous system and not in the peripheral organs." @default.
- W190058637 created "2016-06-24" @default.
- W190058637 creator A5056101168 @default.
- W190058637 creator A5064375891 @default.
- W190058637 creator A5083968750 @default.
- W190058637 date "2004-01-01" @default.
- W190058637 modified "2023-09-26" @default.
- W190058637 title "Propiedades neuroprotectoras de los esteroides sexuales y los neuroesteroides" @default.
- W190058637 cites W1514048741 @default.
- W190058637 cites W1522117207 @default.
- W190058637 cites W1543220690 @default.
- W190058637 cites W1553342043 @default.
- W190058637 cites W1563459863 @default.
- W190058637 cites W1564311086 @default.
- W190058637 cites W1582815982 @default.
- W190058637 cites W1593442063 @default.
- W190058637 cites W1912224219 @default.
- W190058637 cites W1922088893 @default.
- W190058637 cites W1937097615 @default.
- W190058637 cites W1954362983 @default.
- W190058637 cites W1963783263 @default.
- W190058637 cites W1965370016 @default.
- W190058637 cites W1966136360 @default.
- W190058637 cites W1966627384 @default.
- W190058637 cites W1967399572 @default.
- W190058637 cites W1968981889 @default.
- W190058637 cites W1973388458 @default.
- W190058637 cites W1974995319 @default.
- W190058637 cites W1977374270 @default.
- W190058637 cites W1977827405 @default.
- W190058637 cites W1983191112 @default.
- W190058637 cites W1983702345 @default.
- W190058637 cites W1988079556 @default.
- W190058637 cites W1991017405 @default.
- W190058637 cites W1992919675 @default.
- W190058637 cites W1992983370 @default.
- W190058637 cites W1994096100 @default.
- W190058637 cites W1996996773 @default.
- W190058637 cites W1998921666 @default.
- W190058637 cites W1999976079 @default.
- W190058637 cites W2001853114 @default.
- W190058637 cites W2003593774 @default.
- W190058637 cites W2006521167 @default.
- W190058637 cites W2007980908 @default.
- W190058637 cites W2008392190 @default.
- W190058637 cites W2008871773 @default.
- W190058637 cites W2009434677 @default.
- W190058637 cites W2012767314 @default.
- W190058637 cites W2014229349 @default.
- W190058637 cites W2014389746 @default.
- W190058637 cites W2018769555 @default.
- W190058637 cites W2020392235 @default.
- W190058637 cites W2021198860 @default.
- W190058637 cites W2022732642 @default.
- W190058637 cites W2023651401 @default.
- W190058637 cites W2024261373 @default.
- W190058637 cites W2028266700 @default.
- W190058637 cites W2028466691 @default.
- W190058637 cites W2031410274 @default.
- W190058637 cites W2032562748 @default.
- W190058637 cites W2035147784 @default.
- W190058637 cites W2035244476 @default.
- W190058637 cites W2037148314 @default.
- W190058637 cites W2040329969 @default.
- W190058637 cites W2045244003 @default.
- W190058637 cites W2047844288 @default.
- W190058637 cites W2048021529 @default.
- W190058637 cites W2048463939 @default.
- W190058637 cites W2048835444 @default.
- W190058637 cites W2049559677 @default.
- W190058637 cites W2049703902 @default.
- W190058637 cites W2055299738 @default.
- W190058637 cites W2055910116 @default.
- W190058637 cites W2056526451 @default.
- W190058637 cites W2058069935 @default.
- W190058637 cites W2058259438 @default.
- W190058637 cites W2058269906 @default.
- W190058637 cites W2058922609 @default.
- W190058637 cites W2059493445 @default.
- W190058637 cites W2059756889 @default.
- W190058637 cites W2061369072 @default.
- W190058637 cites W2062937887 @default.
- W190058637 cites W2063032404 @default.
- W190058637 cites W2063312700 @default.
- W190058637 cites W2064784013 @default.
- W190058637 cites W2067642579 @default.
- W190058637 cites W2067996406 @default.
- W190058637 cites W2068100113 @default.
- W190058637 cites W2068914179 @default.
- W190058637 cites W2071346815 @default.
- W190058637 cites W2071824631 @default.
- W190058637 cites W2074054937 @default.
- W190058637 cites W2075990267 @default.
- W190058637 cites W2079590715 @default.
- W190058637 cites W2083447043 @default.
- W190058637 cites W2084054825 @default.
- W190058637 cites W2087022458 @default.
- W190058637 cites W2088290994 @default.
- W190058637 cites W2089826638 @default.
- W190058637 cites W2090984888 @default.