FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1900638061> ?p ?o ?g. }

• W1900638061 endingPage "1391" @default.
• W1900638061 startingPage "1379" @default.
• W1900638061 abstract "Mesenchymal stem cells (MSCs) have the potential to treat early intervertebral disc (IVD) degeneration. However, during intradiscal injection, the vast majority of cells leaked out even in the presence of hydrogel carrier. Recent evidence suggests that annulus puncture is associated with cell leakage and contributes to osteophyte formation, an undesirable side effect. This suggests the significance of developing appropriate carriers for intradiscal delivery of MSCs. We previously developed a collagen microencapsulation platform, which entraps MSCs in a solid microsphere consisting of collagen nanofiber meshwork. These solid yet porous microspheres support MSC attachment, survival, proliferation, migration, differentiation, and matrix remodeling. Here we hypothesize that intradiscal injection of MSCs in collagen microspheres will outperform that of MSCs in saline in terms of better functional outcomes and reduced side effects. Specifically, we induced disc degeneration in rabbits and then intradiscally injected autologous MSCs, either packaged within collagen microspheres or directly suspended in saline, into different disc levels. Functional outcomes including hydration index and disc height were monitored regularly until 6 months. Upon sacrifice, the involved discs were harvested for histological, biochemical, and biomechanical evaluations. MSCs in collagen microspheres showed advantage over MSCs in saline in better maintaining the dynamic mechanical behavior but similar performance in hydration and disc height maintenance and matrix composition. More importantly, upon examination of gross appearance, radiograph, and histology of IVD, delivering MSCs in collagen microspheres significantly reduced the risk of osteophyte formation as compared to that in saline. This work demonstrates the significance of using cell carriers during intradiscal injection of MSCs in treating disc degeneration." @default.
• W1900638061 created "2016-06-24" @default.
• W1900638061 creator A5018339704 @default.
• W1900638061 creator A5021712500 @default.
• W1900638061 creator A5025442678 @default.
• W1900638061 creator A5033087275 @default.
• W1900638061 creator A5034551007 @default.
• W1900638061 creator A5059355974 @default.
• W1900638061 creator A5066756999 @default.
• W1900638061 creator A5081751266 @default.
• W1900638061 date "2014-05-01" @default.
• W1900638061 modified "2023-10-01" @default.
• W1900638061 title "Delivering Mesenchymal Stem Cells in Collagen Microsphere Carriers to Rabbit Degenerative Disc: Reduced Risk of Osteophyte Formation" @default.
• W1900638061 cites W1533220576 @default.
• W1900638061 cites W1573068629 @default.
• W1900638061 cites W1587481675 @default.
• W1900638061 cites W1964148859 @default.
• W1900638061 cites W1967114942 @default.
• W1900638061 cites W1968049906 @default.
• W1900638061 cites W1970365602 @default.
• W1900638061 cites W1972802528 @default.
• W1900638061 cites W1973996314 @default.
• W1900638061 cites W1975321623 @default.
• W1900638061 cites W1983661883 @default.
• W1900638061 cites W1989517472 @default.
• W1900638061 cites W1991606527 @default.
• W1900638061 cites W1994225824 @default.
• W1900638061 cites W1997187415 @default.
• W1900638061 cites W1997420170 @default.
• W1900638061 cites W2000037487 @default.
• W1900638061 cites W2004371584 @default.
• W1900638061 cites W2007257271 @default.
• W1900638061 cites W2011471203 @default.
• W1900638061 cites W2013987712 @default.
• W1900638061 cites W2015073667 @default.
• W1900638061 cites W2019643084 @default.
• W1900638061 cites W2026283108 @default.
• W1900638061 cites W2028215624 @default.
• W1900638061 cites W2037998434 @default.
• W1900638061 cites W2042470556 @default.
• W1900638061 cites W2042877237 @default.
• W1900638061 cites W2054061931 @default.
• W1900638061 cites W2055802675 @default.
• W1900638061 cites W2056290343 @default.
• W1900638061 cites W2057840832 @default.
• W1900638061 cites W2060555808 @default.
• W1900638061 cites W2065852945 @default.
• W1900638061 cites W2068030474 @default.
• W1900638061 cites W2072824523 @default.
• W1900638061 cites W2076923477 @default.
• W1900638061 cites W2078921853 @default.
• W1900638061 cites W2079387407 @default.
• W1900638061 cites W2082578015 @default.
• W1900638061 cites W2085517026 @default.
• W1900638061 cites W2114804734 @default.
• W1900638061 cites W2140617608 @default.
• W1900638061 cites W2150208538 @default.
• W1900638061 cites W2153052074 @default.
• W1900638061 cites W2154900539 @default.
• W1900638061 cites W2155935443 @default.
• W1900638061 cites W2159589593 @default.
• W1900638061 cites W2162435517 @default.
• W1900638061 cites W2165190715 @default.
• W1900638061 cites W2170195200 @default.
• W1900638061 cites W2315418913 @default.
• W1900638061 cites W2342571638 @default.
• W1900638061 cites W4237446505 @default.
• W1900638061 cites W4246399897 @default.
• W1900638061 doi "https://doi.org/10.1089/ten.tea.2013.0498" @default.
• W1900638061 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4011461" @default.
• W1900638061 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24372278" @default.
• W1900638061 hasPublicationYear "2014" @default.
• W1900638061 type Work @default.
• W1900638061 sameAs 1900638061 @default.
• W1900638061 citedByCount "35" @default.
• W1900638061 countsByYear W19006380612015 @default.
• W1900638061 countsByYear W19006380612016 @default.
• W1900638061 countsByYear W19006380612017 @default.
• W1900638061 countsByYear W19006380612018 @default.
• W1900638061 countsByYear W19006380612019 @default.
• W1900638061 countsByYear W19006380612020 @default.
• W1900638061 countsByYear W19006380612021 @default.
• W1900638061 countsByYear W19006380612022 @default.
• W1900638061 countsByYear W19006380612023 @default.
• W1900638061 crossrefType "journal-article" @default.
• W1900638061 hasAuthorship W1900638061A5018339704 @default.
• W1900638061 hasAuthorship W1900638061A5021712500 @default.
• W1900638061 hasAuthorship W1900638061A5025442678 @default.
• W1900638061 hasAuthorship W1900638061A5033087275 @default.
• W1900638061 hasAuthorship W1900638061A5034551007 @default.
• W1900638061 hasAuthorship W1900638061A5059355974 @default.
• W1900638061 hasAuthorship W1900638061A5066756999 @default.
• W1900638061 hasAuthorship W1900638061A5081751266 @default.
• W1900638061 hasBestOaLocation W19006380612 @default.
• W1900638061 hasConcept C105702510 @default.
• W1900638061 hasConcept C126322002 @default.
• W1900638061 hasConcept C136229726 @default.
• W1900638061 hasConcept C142724271 @default.

• next