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• W1900641812 abstract "Acute exercise is known to activate the immune system and thus could lead to increased human immunodeficiency virus (HIV) replication. We sought to determine whether a single acute bout of exercise, similar to what people experience when starting an intensive exercise program, has a detrimental effect on plasma HIV RNA levels. Twenty-five patients with HIV infection performed one 15-min bout of acute exercise. Absolute neutrophil counts, serum creatine phosphokinase, and 72-h urinary 3-methylhistidine (a marker of muscle protein breakdown) were measured before and after the exercise, along with plasma HIV RNA levels. There were increases in neutrophil counts ( P < 0.06), serum creatine phosphokinase ( P < 0.01), and urinary 3-methylhistidine ( P < 0.01) in response to exercise, indicating a mild acute-phase response with muscle proteolysis. However, mean HIV RNA, which was elevated at baseline in 22 of the 25 subjects (mean of 4 × 10 5 ± 0.7 × 10 5 copies/ml), did not increase during the week after exercise ( P = 0.12). Small changes in RNA were seen in the three subjects with initially undetectable HIV RNA, but the significance of these changes is unclear. Acute exercise does not have a deleterious effect on HIV replication in adults with high viral loads. Because regular exercise training has not been shown to activate the acute-phase response, the lack of increased viral loads in response to an acute exercise intervention suggests that exercise training is safe in people with HIV infection." @default.
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• W1900641812 date "1999-04-01" @default.
• W1900641812 modified "2023-10-14" @default.
• W1900641812 title "Effect of a single bout of acute exercise on plasma human immunodeficiency virus RNA levels" @default.
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• W1900641812 doi "https://doi.org/10.1152/jappl.1999.86.4.1197" @default.
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