FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1900663669> ?p ?o ?g. }

• W1900663669 endingPage "532" @default.
• W1900663669 startingPage "523" @default.
• W1900663669 abstract "Cancer-initiating cells (CICs) that are responsible for tumor initiation, propagation, and resistance to standard therapies have been isolated from human solid tumors, including colorectal cancer (CRC). The aim of this study was to obtain an immunological profile of CRC-derived CICs and to identify CIC-associated target molecules for T cell immunotherapy. We have isolated cells with CIC properties along with their putative non-CIC autologous counterparts from human primary CRC tissues. These CICs have been shown to display tumor-initiating/stemness properties, including the expression of CIC-associated markers (e.g., CD44, CD24, ALDH-1, EpCAM, Lgr5), multipotency, and tumorigenicity following injection in immunodeficient mice. The immune profile of these cells was assessed by phenotype analysis and by in vitro stimulation of PBMCs with CICs as a source of Ags. CICs, compared with non-CIC counterparts, showed weak immunogenicity. This feature correlated with the expression of high levels of immunomodulatory molecules, such as IL-4, and with CIC-mediated inhibitory activity for anti-tumor T cell responses. CIC-associated IL-4 was found to be responsible for this negative function, which requires cell-to-cell contact with T lymphocytes and which is impaired by blocking IL-4 signaling. In addition, the CRC-associated Ag COA-1 was found to be expressed by CICs and to represent, in an autologous setting, a target molecule for anti-tumor T cells. Our study provides relevant information that may contribute to designing new immunotherapy protocols to target CICs in CRC patients." @default.
• W1900663669 created "2016-06-24" @default.
• W1900663669 creator A5003467210 @default.
• W1900663669 creator A5006282551 @default.
• W1900663669 creator A5035654174 @default.
• W1900663669 creator A5039979956 @default.
• W1900663669 creator A5047380313 @default.
• W1900663669 creator A5048402257 @default.
• W1900663669 creator A5049436555 @default.
• W1900663669 creator A5058364747 @default.
• W1900663669 creator A5058947920 @default.
• W1900663669 creator A5062210857 @default.
• W1900663669 creator A5067317332 @default.
• W1900663669 creator A5077760288 @default.
• W1900663669 creator A5078970596 @default.
• W1900663669 creator A5080707712 @default.
• W1900663669 creator A5081413850 @default.
• W1900663669 creator A5088239980 @default.
• W1900663669 date "2013-11-25" @default.
• W1900663669 modified "2023-10-18" @default.
• W1900663669 title "Cancer-Initiating Cells from Colorectal Cancer Patients Escape from T Cell–Mediated Immunosurveillance In Vitro through Membrane-Bound IL-4" @default.
• W1900663669 cites W1975992482 @default.
• W1900663669 cites W1977169442 @default.
• W1900663669 cites W1977876646 @default.
• W1900663669 cites W1985076753 @default.
• W1900663669 cites W1992119951 @default.
• W1900663669 cites W1992782005 @default.
• W1900663669 cites W2010884432 @default.
• W1900663669 cites W2013852385 @default.
• W1900663669 cites W2018671779 @default.
• W1900663669 cites W2020131167 @default.
• W1900663669 cites W2024682726 @default.
• W1900663669 cites W2027137330 @default.
• W1900663669 cites W2043772256 @default.
• W1900663669 cites W2052892134 @default.
• W1900663669 cites W2053693308 @default.
• W1900663669 cites W2060551076 @default.
• W1900663669 cites W2081447858 @default.
• W1900663669 cites W2096992832 @default.
• W1900663669 cites W2107575018 @default.
• W1900663669 cites W2111065592 @default.
• W1900663669 cites W2116170249 @default.
• W1900663669 cites W2129644533 @default.
• W1900663669 cites W2130234264 @default.
• W1900663669 cites W2147669376 @default.
• W1900663669 cites W2151386025 @default.
• W1900663669 cites W2151395921 @default.
• W1900663669 cites W2156381851 @default.
• W1900663669 cites W2158049101 @default.
• W1900663669 cites W2158293719 @default.
• W1900663669 cites W2160425962 @default.
• W1900663669 cites W2165354678 @default.
• W1900663669 doi "https://doi.org/10.4049/jimmunol.1301342" @default.
• W1900663669 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24277698" @default.
• W1900663669 hasPublicationYear "2013" @default.
• W1900663669 type Work @default.
• W1900663669 sameAs 1900663669 @default.
• W1900663669 citedByCount "91" @default.
• W1900663669 countsByYear W19006636692014 @default.
• W1900663669 countsByYear W19006636692015 @default.
• W1900663669 countsByYear W19006636692016 @default.
• W1900663669 countsByYear W19006636692017 @default.
• W1900663669 countsByYear W19006636692018 @default.
• W1900663669 countsByYear W19006636692019 @default.
• W1900663669 countsByYear W19006636692020 @default.
• W1900663669 countsByYear W19006636692021 @default.
• W1900663669 countsByYear W19006636692022 @default.
• W1900663669 countsByYear W19006636692023 @default.
• W1900663669 crossrefType "journal-article" @default.
• W1900663669 hasAuthorship W1900663669A5003467210 @default.
• W1900663669 hasAuthorship W1900663669A5006282551 @default.
• W1900663669 hasAuthorship W1900663669A5035654174 @default.
• W1900663669 hasAuthorship W1900663669A5039979956 @default.
• W1900663669 hasAuthorship W1900663669A5047380313 @default.
• W1900663669 hasAuthorship W1900663669A5048402257 @default.
• W1900663669 hasAuthorship W1900663669A5049436555 @default.
• W1900663669 hasAuthorship W1900663669A5058364747 @default.
• W1900663669 hasAuthorship W1900663669A5058947920 @default.
• W1900663669 hasAuthorship W1900663669A5062210857 @default.
• W1900663669 hasAuthorship W1900663669A5067317332 @default.
• W1900663669 hasAuthorship W1900663669A5077760288 @default.
• W1900663669 hasAuthorship W1900663669A5078970596 @default.
• W1900663669 hasAuthorship W1900663669A5080707712 @default.
• W1900663669 hasAuthorship W1900663669A5081413850 @default.
• W1900663669 hasAuthorship W1900663669A5088239980 @default.
• W1900663669 hasBestOaLocation W19006636691 @default.
• W1900663669 hasConcept C121608353 @default.
• W1900663669 hasConcept C126322002 @default.
• W1900663669 hasConcept C1491633281 @default.
• W1900663669 hasConcept C203014093 @default.
• W1900663669 hasConcept C2776090121 @default.
• W1900663669 hasConcept C2776885095 @default.
• W1900663669 hasConcept C2777701055 @default.
• W1900663669 hasConcept C2780674031 @default.
• W1900663669 hasConcept C2780868878 @default.
• W1900663669 hasConcept C2780932548 @default.
• W1900663669 hasConcept C502942594 @default.
• W1900663669 hasConcept C526805850 @default.

• next