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- W1901179623 abstract "Recently Bean et al. (1) compared isoelectric focusing/immunoblotting/laser densitometry (IEF/IB/LD), Axis %CDT TIA, and Axis %CDT HPLC for the determination of CDT. This study shows shortcomings that need further discussion.1. The three methods, as presented in Materials and Methods in that paper, are not semiautomated. The statement that “similar results are obtained on an array of turbidimetric instruments … ” on page 987 cannot be deduced from the data presented. None of the 10 analyzers mentioned was tested in this study, and appropriate references are not given. Thus, the title does not reflect the content of the paper.2. On page 983, the authors state that “inclusion of the trisialotransferrin fraction increases the accuracy in the diagnosis of sustained alcohol usage.” However, on page 988, the discussion ends with “whether the inclusion of the trisialotransferrins results in improved efficacy of the test awaits further analysis… ”3. Predictive values, diagnostic sensitivities, and specificities strongly depend on the definition of false positives and negatives and patients’ sex and liver function (2). However, no information is given on how daily alcohol consumption for groups 1–4 was verified. Furthermore, groups 2–4 combine men and women (with and without alcohol-induced liver disease). Although gender-specific upper reference limits of CDT are described in detail and generally accepted (2), the authors establish gender-nonspecific cutoffs without giving any reasons for this procedure.4. The study illustrates the need for a unified definition of CDT. On page 983, the IEF/IB/LD is said to summarize asialo-, mono-, and disialotransferrins as CDT; on pages 984, 987, and 988, only asialo- and disialotransferrin. %CDT TIA analyzes asialo-, mono-, di-, and 50% of trisialotransferrin; %CDT HPLC mono-, di-, and 50% of trisialotransferrin but not asialotransferrin (pages 984–985). IEF/IB/LD measures partially iron-loaded, %CDT TIA, and %CDT HPLC iron-saturated isotransferrins. Thus, CDT values …" @default.
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- W1901179623 date "1998-05-01" @default.
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- W1901179623 title "Evaluation of Carbohydrate-deficient Transferrin" @default.
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- W1901179623 doi "https://doi.org/10.1093/clinchem/44.5.1069" @default.
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