FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1901192183> ?p ?o ?g. }

• W1901192183 endingPage "74" @default.
• W1901192183 startingPage "66" @default.
• W1901192183 abstract "Abstract The transcription factor aryl hydrocarbon receptor (AhR) represents a promising therapeutic target in allergy and autoimmunity. AhR signaling induced by the newly described ligand VAF347 inhibits allergic lung inflammation as well as suppresses pancreatic islet allograft rejection. These effects are likely mediated via alterations in dendritic cell (DC) function. Moreover, VAF347 induces tolerogenic DCs. Langerhans cells (LCs) are immediate targets of exogenous AhR ligands at epithelial surfaces; how they respond to AhR ligands remained undefined. We studied AhR expression and function in human LCs and myelopoietic cell subsets using a lineage differentiation and gene transduction model of human CD34+ hematopoietic progenitors. We found that AhR is highly regulated during myeloid subset differentiation. LCs expressed highest AhR levels followed by monocytes. Conversely, neutrophil granulocytes lacked AhR expression. AhR ligands including VAF347 arrested the differentiation of monocytes and LCs at an early precursor cell stage, whereas progenitor cell expansion or granulopoiesis remained unimpaired. AhR expression was coregulated with the transcription factor PU.1 during myeloid subset differentiation. VAF347 inhibited PU.1 induction during initial monocytic differentiation, and ectopic PU.1 restored monocyte and LC generation in the presence of this compound. AhR ligands failed to interfere with cytokine receptor signaling during LC differentiation and failed to impair LC activation/maturation. VAF347-mediated antiproliferative effect on precursors undergoing LC lineage differentiation occurred in a clinically applicable serum-free culture model and was not accompanied by apoptosis induction. In conclusion, AhR agonist signaling interferes with transcriptional processes leading to monocyte/DC lineage commitment of human myeloid progenitor cells." @default.
• W1901192183 created "2016-06-24" @default.
• W1901192183 creator A5004159510 @default.
• W1901192183 creator A5007044655 @default.
• W1901192183 creator A5016994968 @default.
• W1901192183 creator A5043218723 @default.
• W1901192183 creator A5053265429 @default.
• W1901192183 creator A5082197804 @default.
• W1901192183 date "2009-07-01" @default.
• W1901192183 modified "2023-10-15" @default.
• W1901192183 title "Aryl Hydrocarbon Receptor Activation Inhibits In Vitro Differentiation of Human Monocytes and Langerhans Dendritic Cells" @default.
• W1901192183 cites W101346790 @default.
• W1901192183 cites W1537989154 @default.
• W1901192183 cites W1542731022 @default.
• W1901192183 cites W1600921312 @default.
• W1901192183 cites W1607733107 @default.
• W1901192183 cites W1935479846 @default.
• W1901192183 cites W1969656285 @default.
• W1901192183 cites W1972589365 @default.
• W1901192183 cites W1987710674 @default.
• W1901192183 cites W1989986502 @default.
• W1901192183 cites W1993003564 @default.
• W1901192183 cites W1997645342 @default.
• W1901192183 cites W1998573431 @default.
• W1901192183 cites W2004522121 @default.
• W1901192183 cites W2008368254 @default.
• W1901192183 cites W2020096770 @default.
• W1901192183 cites W2027175206 @default.
• W1901192183 cites W2029275372 @default.
• W1901192183 cites W2051502288 @default.
• W1901192183 cites W2069759825 @default.
• W1901192183 cites W2087332917 @default.
• W1901192183 cites W2089069133 @default.
• W1901192183 cites W2094734927 @default.
• W1901192183 cites W2097998083 @default.
• W1901192183 cites W2098180946 @default.
• W1901192183 cites W2101071262 @default.
• W1901192183 cites W2104532242 @default.
• W1901192183 cites W2107817160 @default.
• W1901192183 cites W2138997493 @default.
• W1901192183 cites W2141442441 @default.
• W1901192183 cites W2143200827 @default.
• W1901192183 cites W2144062280 @default.
• W1901192183 cites W2145569891 @default.
• W1901192183 cites W2146909058 @default.
• W1901192183 cites W2164523857 @default.
• W1901192183 cites W2218756884 @default.
• W1901192183 cites W4244492486 @default.
• W1901192183 cites W4247274519 @default.
• W1901192183 cites W4251143684 @default.
• W1901192183 cites W4313347804 @default.
• W1901192183 doi "https://doi.org/10.4049/jimmunol.0802997" @default.
• W1901192183 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19535631" @default.
• W1901192183 hasPublicationYear "2009" @default.
• W1901192183 type Work @default.
• W1901192183 sameAs 1901192183 @default.
• W1901192183 citedByCount "91" @default.
• W1901192183 countsByYear W19011921832012 @default.
• W1901192183 countsByYear W19011921832013 @default.
• W1901192183 countsByYear W19011921832014 @default.
• W1901192183 countsByYear W19011921832015 @default.
• W1901192183 countsByYear W19011921832016 @default.
• W1901192183 countsByYear W19011921832017 @default.
• W1901192183 countsByYear W19011921832018 @default.
• W1901192183 countsByYear W19011921832019 @default.
• W1901192183 countsByYear W19011921832020 @default.
• W1901192183 countsByYear W19011921832021 @default.
• W1901192183 countsByYear W19011921832022 @default.
• W1901192183 countsByYear W19011921832023 @default.
• W1901192183 crossrefType "journal-article" @default.
• W1901192183 hasAuthorship W1901192183A5004159510 @default.
• W1901192183 hasAuthorship W1901192183A5007044655 @default.
• W1901192183 hasAuthorship W1901192183A5016994968 @default.
• W1901192183 hasAuthorship W1901192183A5043218723 @default.
• W1901192183 hasAuthorship W1901192183A5053265429 @default.
• W1901192183 hasAuthorship W1901192183A5082197804 @default.
• W1901192183 hasBestOaLocation W19011921831 @default.
• W1901192183 hasConcept C104317684 @default.
• W1901192183 hasConcept C109159458 @default.
• W1901192183 hasConcept C148738053 @default.
• W1901192183 hasConcept C201750760 @default.
• W1901192183 hasConcept C203014093 @default.
• W1901192183 hasConcept C2778170410 @default.
• W1901192183 hasConcept C2779282312 @default.
• W1901192183 hasConcept C2781184567 @default.
• W1901192183 hasConcept C28328180 @default.
• W1901192183 hasConcept C33594762 @default.
• W1901192183 hasConcept C502942594 @default.
• W1901192183 hasConcept C54355233 @default.
• W1901192183 hasConcept C55493867 @default.
• W1901192183 hasConcept C81885089 @default.
• W1901192183 hasConcept C86339819 @default.
• W1901192183 hasConcept C86803240 @default.
• W1901192183 hasConcept C8891405 @default.
• W1901192183 hasConcept C95444343 @default.
• W1901192183 hasConcept C95862172 @default.
• W1901192183 hasConcept C97037327 @default.
• W1901192183 hasConceptScore W1901192183C104317684 @default.

• next