FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1901264013> ?p ?o ?g. }

• W1901264013 endingPage "1057" @default.
• W1901264013 startingPage "1046" @default.
• W1901264013 abstract "Ethanol is a teratogen affecting numerous regions of the developing nervous system. The present study was undertaken to ascertain whether ethanol independently disrupts distinct signaling pathways or rather disrupts interactive pathways that regulate development of ethanol-sensitive tissues.Zebrafish embryos were exposed to ethanol in the absence or presence of aldh1a3 or Shh morpholino oligonucleotides (MOs), which disrupt retinoic acid (RA) or sonic hedgehog (Shh) function, respectively. Morphological analysis of ocular or midbrain-hindbrain boundary (MHB) development was conducted, and the ability to rescue ethanol and MO-induced phenotypes was assessed. In situ hybridization was used to analyze Pax6a expression during ocular development.Chronic ethanol exposure, or combined ethanol and MO treatment, results in perturbed MHB formation and microphthalmia. While RA can rescue the MHB phenotype following ethanol combined with either MO, Shh mRNA is unable to rescue the disrupted MHB with combined ethanol and aldh1a3 MO treatment. RA also is unable to rescue microphthalmia induced by ethanol and Shh MO.These studies demonstrate that while reduction of either RA or Shh signaling produces the same disruption of MHB or ocular development, that can be phenocopied using ethanol combined with either MO, RA overexpression can only rescue disrupted MHB, but not microphthalmia, in combined subthreshold Shh MO and ethanol. Our data suggest that MHB development may involve crosstalk between RA and Shh signaling, while ocular development depends on RA and Shh signaling that both are targets of ethanol in fetal alcohol spectrum disorders but do not depend on a mechanism involving crosstalk." @default.
• W1901264013 created "2016-06-24" @default.
• W1901264013 creator A5019302810 @default.
• W1901264013 creator A5070406068 @default.
• W1901264013 creator A5084281207 @default.
• W1901264013 date "2015-10-16" @default.
• W1901264013 modified "2023-09-25" @default.
• W1901264013 title "Analysis of crosstalk between retinoic acid and sonic hedgehog pathways following ethanol exposure in embryonic zebrafish" @default.
• W1901264013 cites W1832039973 @default.
• W1901264013 cites W1886582022 @default.
• W1901264013 cites W1924348167 @default.
• W1901264013 cites W1970030634 @default.
• W1901264013 cites W1972700427 @default.
• W1901264013 cites W1979268604 @default.
• W1901264013 cites W1980976351 @default.
• W1901264013 cites W1985222746 @default.
• W1901264013 cites W1989965266 @default.
• W1901264013 cites W1999470756 @default.
• W1901264013 cites W2001483570 @default.
• W1901264013 cites W2006949179 @default.
• W1901264013 cites W2007961588 @default.
• W1901264013 cites W2011354935 @default.
• W1901264013 cites W2011381351 @default.
• W1901264013 cites W2013210063 @default.
• W1901264013 cites W2014004319 @default.
• W1901264013 cites W2018382599 @default.
• W1901264013 cites W2018747978 @default.
• W1901264013 cites W2030737203 @default.
• W1901264013 cites W2030792858 @default.
• W1901264013 cites W2031923494 @default.
• W1901264013 cites W2032162529 @default.
• W1901264013 cites W2035528004 @default.
• W1901264013 cites W2038031724 @default.
• W1901264013 cites W2038837562 @default.
• W1901264013 cites W2040017882 @default.
• W1901264013 cites W2040781457 @default.
• W1901264013 cites W2053255267 @default.
• W1901264013 cites W2053698522 @default.
• W1901264013 cites W2055681338 @default.
• W1901264013 cites W2057717537 @default.
• W1901264013 cites W2062109052 @default.
• W1901264013 cites W2066631134 @default.
• W1901264013 cites W2069051135 @default.
• W1901264013 cites W2073230598 @default.
• W1901264013 cites W2073255901 @default.
• W1901264013 cites W2074797226 @default.
• W1901264013 cites W2076251423 @default.
• W1901264013 cites W2083229403 @default.
• W1901264013 cites W2089235055 @default.
• W1901264013 cites W2093419101 @default.
• W1901264013 cites W2099444111 @default.
• W1901264013 cites W2100822894 @default.
• W1901264013 cites W2109033307 @default.
• W1901264013 cites W2119287599 @default.
• W1901264013 cites W2120382859 @default.
• W1901264013 cites W2121381454 @default.
• W1901264013 cites W2132648716 @default.
• W1901264013 cites W2134453979 @default.
• W1901264013 cites W2136869125 @default.
• W1901264013 cites W2139841346 @default.
• W1901264013 cites W2152867201 @default.
• W1901264013 cites W2159534153 @default.
• W1901264013 cites W2170661306 @default.
• W1901264013 cites W2171521049 @default.
• W1901264013 cites W2234584180 @default.
• W1901264013 cites W2277071306 @default.
• W1901264013 cites W2915952288 @default.
• W1901264013 doi "https://doi.org/10.1002/bdra.23460" @default.
• W1901264013 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4697881" @default.
• W1901264013 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26470995" @default.
• W1901264013 hasPublicationYear "2015" @default.
• W1901264013 type Work @default.
• W1901264013 sameAs 1901264013 @default.
• W1901264013 citedByCount "14" @default.
• W1901264013 countsByYear W19012640132016 @default.
• W1901264013 countsByYear W19012640132017 @default.
• W1901264013 countsByYear W19012640132018 @default.
• W1901264013 countsByYear W19012640132019 @default.
• W1901264013 countsByYear W19012640132020 @default.
• W1901264013 countsByYear W19012640132021 @default.
• W1901264013 countsByYear W19012640132022 @default.
• W1901264013 crossrefType "journal-article" @default.
• W1901264013 hasAuthorship W1901264013A5019302810 @default.
• W1901264013 hasAuthorship W1901264013A5070406068 @default.
• W1901264013 hasAuthorship W1901264013A5084281207 @default.
• W1901264013 hasBestOaLocation W19012640132 @default.
• W1901264013 hasConcept C104317684 @default.
• W1901264013 hasConcept C120665830 @default.
• W1901264013 hasConcept C121332964 @default.
• W1901264013 hasConcept C150194340 @default.
• W1901264013 hasConcept C169822122 @default.
• W1901264013 hasConcept C2776637008 @default.
• W1901264013 hasConcept C2776878037 @default.
• W1901264013 hasConcept C2777605378 @default.
• W1901264013 hasConcept C2778085061 @default.
• W1901264013 hasConcept C2781121885 @default.
• W1901264013 hasConcept C54355233 @default.
• W1901264013 hasConcept C55493867 @default.

• next