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- W1901528025 abstract "The intrauterine biochemical assessment of the human fetus is important in fetal medicine, for both prenatal diagnosis and therapy of fetal diseases. Percutaneous umbilical blood sampling (PUBS) performed with ultrasound guidance is reliable for this, and the microvolume specimens obtained by this technique are readily analyzed by modern clinical chemistry analyzers to perform complete biochemical profiles with small blood volumes.The interpretation of fetal biochemical tests requires age-gestational specific reference intervals to reveal possible pathological processes and to minimize the remarkable physiological variability observed with fetal growth and maturation, particularly in the last trimester of gestation. Various cord blood analytes have been investigated as potential indicators of fetal distress (1)(2), but no comprehensive report of reference intervals adjusted to various weeks of gestation has been available. Here, we present reference intervals for 18 analytes in plasma samples obtained by PUBS from 72 healthy fetuses between weeks 18 and 40 of pregnancy.We analyzed plasma from 171 fetuses who underwent PUBS between the 18th and 40th week of gestation for various indications (Rh alloimmunization 79, maternal viral or parasitic infection 42, rapid karyotyping 25, and maternal thrombocytopenia 25). Informed consent was obtained from the parents. Gestational age at the time of sampling was determined from menstrual dates or by ultrasonography when the dates were uncertain. We selected 72 fetuses as “healthy” when the …" @default.
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- W1901528025 date "1998-03-01" @default.
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- W1901528025 title "Reference intervals for 18 clinical chemistry analytes in fetal plasma samples between 18 and 40 weeks of pregnancy." @default.
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