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• W1901749480 abstract "Health organisations recommend exclusive breastfeeding for six months. However, the addition of other fluids or foods before six months is common in many countries. Recently, research has suggested that introducing solid food at around four months of age while the baby continues to breastfeed is more protective against developing food allergies compared to exclusive breastfeeding for six months. Other studies have shown that the risks associated with non-exclusive breastfeeding are dependent on the type of additional food or fluid given. Given this background we felt it was important to update the previous version of this review to incorporate the latest findings from studies examining exclusive compared to non-exclusive breastfeeding.To assess the benefits and harms of additional food or fluid for full-term healthy breastfeeding infants and to examine the timing and type of additional food or fluid.We searched the Cochrane Pregnancy and Childbirth Group's Trials Register (1 March 2016) and reference lists of all relevant retrieved papers.Randomised or quasi-randomised controlled trials in infants under six months of age comparing exclusive breastfeeding versus breastfeeding with any additional food or fluids.Two review authors independently assessed trials for inclusion and risk of bias, extracted data and checked them for accuracy. Two review authors assessed the quality of the evidence using the GRADE approach.We included 11 trials (2542 randomised infants/mothers). Nine trials (2226 analysed) provided data on outcomes of interest to this review. The variation in outcome measures and time points made it difficult to pool results from trials. Data could only be combined in a meta-analysis for one primary (breastfeeding duration) and one secondary (weight change) outcome. None of the trials reported on physiological jaundice. Infant mortality was only reported in one trial.For the majority of older trials, the description of study methods was inadequate to assess the risk of bias. Most studies that we could assess showed a high risk of other biases and over half were at high risk of selection bias.Providing breastfeeding infants with artifical milk, compared to exclusive breastfeeding, did not affect rates of breastfeeding at hospital discharge (risk ratio (RR) 1.02, 95% confidence interval (CI) 0.97 to 1.08; one trial, 100 infants; low-quality evidence). At three months, breastfeeding infants who were provided with artificial milk had higher rates of any breastfeeding compared to exclusively breastfeeding infants (RR 1.21, 95% CI 1.05 to 1.41; two trials, 137 infants; low-quality evidence). Infants who were given artifical milk in the first few days after birth before breastfeeding, had less obvious or probable symptoms of allergy compared to exclusively breastfeeding infants (RR 0.56, 95% CI 0.35 to 0.91; one trial, 207 infants; very low-quality evidence). No difference was found in maternal confidence when comparing non-exclusive breastfeeding infants who were provided with artificial milk with exclusive breastfeeding infants (mean difference (MD) 0.10, 95% CI -0.34 to 0.54; one study, 39 infants; low-quality evidence). Rates of breastfeeding were lower in the non-exclusive breastfeeding group compared to the exclusive breastfeeding group at four, eight, 12 (RR 0.68, 95% CI 0.53 to 0.87; one trial, 170 infants; low-quality evidence), 16 and 20 weeks.The addition of glucose water resulted in fewer episodes of hypoglycaemia (below 2.2 mmol/L) compared to the exclusive breastfeeding group, reported at 12 hours (RR 0.07, 95% CI 0.00 to 1.20; one trial, 170 infants; very low-quality evidence), but no significant difference at 24 hours (RR 1.57, 95% CI 0.27 to 9.17; one trial, 170 infants; very low-quality evidence). Weight loss was lower for infants who received additional glucose water (one trial, 170 infants) at six, 12, 24 and 48 hours of life (MD -32.50 g, 95% CI -52.09 to -12.91; low-quality evidence) compared to the exclusively breastfeeding infants but no difference between groups was observed at 72 hours of life (MD 3.00 g, 95% CI -20.83 to 26.83; very low-quality evidence). In another trial with the water and glucose water arms combined (one trial, 47 infants), we found no significant difference in weight loss between the additional fluid group and the exclusively breastfeeding group on either day three or day five (MD -1.03%, 95% CI -2.24 to 0.18; very low-quality evidence) and (MD -0.20%, 95% CI -0.86 to 0.46; very low-quality evidence).Infant mortality was reported in one trial with no deaths occurring in either group (1162 infants). The early introduction of potentially allergenic foods, compared to exclusively breastfeeding, did not reduce the risk of food allergy to one or more of these foods between one to three years of age (RR 0.80, 95% CI 0.51 to 1.25; 1162 children), visible eczema at 12 months stratified by visible eczema at enrolment (RR 0.86, 95% CI 0.51 to 1.44; 284 children), or food protein-induced enterocolitis syndrome reactions (RR 2.00, 95% CI 0.18 to 22.04; 1303 children) (all moderate-quality evidence). Breastfeeding infants receiving additional foods from four months showed no difference in infant weight gain (g) from 16 to 26 weeks compared to exclusive breastfeeding to six months (MD -39.48, 95% CI -128.43 to 49.48; two trials, 260 children; low-quality evidence) or weight z-scores (MD -0.01, 95% CI -0.15 to 0.13; one trial, 100 children; moderate-quality evidence).We found no evidence of benefit to newborn infants on the duration of breastfeeding from the brief use of additional water or glucose water. The quality of the evidence on formula supplementation was insufficient to suggest a change in practice away from exclusive breastfeeding. For infants at four to six months, we found no evidence of benefit from additional foods nor any risks related to morbidity or weight change. The majority of studies showed high risk of other bias and most outcomes were based on low-quality evidence which meant that we were unable to fully assess the benefits or harms of supplementation or to determine the impact from timing and type of supplementation. We found no evidence to disagree with the current international recommendation that healthy infants exclusively breastfeed for the first six months." @default.
• W1901749480 created "2016-06-24" @default.
• W1901749480 creator A5006049514 @default.
• W1901749480 creator A5034466101 @default.
• W1901749480 date "2016-08-30" @default.
• W1901749480 modified "2023-10-09" @default.
• W1901749480 title "Early additional food and fluids for healthy breastfed full-term infants" @default.
• W1901749480 cites W1487330548 @default.
• W1901749480 cites W1490484645 @default.
• W1901749480 cites W1578457266 @default.
• W1901749480 cites W1596007135 @default.
• W1901749480 cites W1596597499 @default.
• W1901749480 cites W1616734531 @default.
• W1901749480 cites W1866292209 @default.
• W1901749480 cites W1868321796 @default.
• W1901749480 cites W1931250722 @default.
• W1901749480 cites W1933921423 @default.
• W1901749480 cites W1958869050 @default.
• W1901749480 cites W1959067726 @default.
• W1901749480 cites W1961285412 @default.
• W1901749480 cites W1963065138 @default.
• W1901749480 cites W1963967761 @default.
• W1901749480 cites W1966349784 @default.
• W1901749480 cites W1973215829 @default.
• W1901749480 cites W1977430591 @default.
• W1901749480 cites W1978209055 @default.
• W1901749480 cites W1979859712 @default.
• W1901749480 cites W1983088689 @default.
• W1901749480 cites W1983783338 @default.
• W1901749480 cites W1983888469 @default.
• W1901749480 cites W1985398357 @default.
• W1901749480 cites W1998253470 @default.
• W1901749480 cites W2002021242 @default.
• W1901749480 cites W2004091982 @default.
• W1901749480 cites W2005505773 @default.
• W1901749480 cites W2012989257 @default.
• W1901749480 cites W2017384459 @default.
• W1901749480 cites W2017840276 @default.
• W1901749480 cites W2018334290 @default.
• W1901749480 cites W2020841295 @default.
• W1901749480 cites W2022248756 @default.
• W1901749480 cites W2024920199 @default.
• W1901749480 cites W2028082519 @default.
• W1901749480 cites W2030391737 @default.
• W1901749480 cites W2036342774 @default.
• W1901749480 cites W2036586977 @default.
• W1901749480 cites W204171329 @default.
• W1901749480 cites W2042777344 @default.
• W1901749480 cites W2045274404 @default.
• W1901749480 cites W2050337910 @default.
• W1901749480 cites W2051112141 @default.
• W1901749480 cites W2055120452 @default.
• W1901749480 cites W2056279446 @default.
• W1901749480 cites W2057848278 @default.
• W1901749480 cites W2059291631 @default.
• W1901749480 cites W2060907348 @default.
• W1901749480 cites W2061326732 @default.
• W1901749480 cites W2063500394 @default.
• W1901749480 cites W2063823695 @default.
• W1901749480 cites W2065210072 @default.
• W1901749480 cites W2066359395 @default.
• W1901749480 cites W2070654990 @default.
• W1901749480 cites W2070798129 @default.
• W1901749480 cites W2076772430 @default.
• W1901749480 cites W2081833937 @default.
• W1901749480 cites W2086123470 @default.
• W1901749480 cites W2088394639 @default.
• W1901749480 cites W2091537221 @default.
• W1901749480 cites W2095061593 @default.
• W1901749480 cites W2101659840 @default.
• W1901749480 cites W2103150323 @default.
• W1901749480 cites W2104399180 @default.
• W1901749480 cites W2105018004 @default.
• W1901749480 cites W2108431196 @default.
• W1901749480 cites W2109750695 @default.
• W1901749480 cites W2109794201 @default.
• W1901749480 cites W2110227348 @default.
• W1901749480 cites W2111170412 @default.
• W1901749480 cites W2112828854 @default.
• W1901749480 cites W2118027842 @default.
• W1901749480 cites W2120249071 @default.
• W1901749480 cites W2124334506 @default.
• W1901749480 cites W2127814935 @default.
• W1901749480 cites W2129496659 @default.
• W1901749480 cites W2130126960 @default.
• W1901749480 cites W2132600113 @default.
• W1901749480 cites W2133312140 @default.
• W1901749480 cites W2133827756 @default.
• W1901749480 cites W2136078839 @default.
• W1901749480 cites W2140952865 @default.
• W1901749480 cites W2141848207 @default.
• W1901749480 cites W2142215748 @default.
• W1901749480 cites W2144287792 @default.
• W1901749480 cites W2145430013 @default.
• W1901749480 cites W2148180950 @default.
• W1901749480 cites W2150071379 @default.
• W1901749480 cites W2150924339 @default.
• W1901749480 cites W2158168633 @default.
• W1901749480 cites W2160820477 @default.
• W1901749480 cites W2161643046 @default.

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