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• W1901786564 endingPage "4175" @default.
• W1901786564 startingPage "4157" @default.
• W1901786564 abstract "ABC transporter mitochondrial 1 (Atm1) and multidrug resistance-like 1 (Mdl) are mitochondrial ABC transporters. Although Atm1 was recently suggested to transport different forms of glutathione from the mitochondrion, which are used for iron-sulfur (Fe-S) cluster maturation in the cytosol, the function of Mdl remains elusive. In Trypanosoma brucei, we identified one homolog of each of these genes, TbAtm and TbMdl, which were downregulated either separately or simultaneously using RNA interference. Individual depletion of TbAtm and TbMdl led to limited growth defects. In cells downregulated for TbAtm, the enzymatic activities of the Fe-S cluster proteins aconitase and fumarase significantly decreased in the cytosol but not in the mitochondrion. Downregulation of TbMdl did not cause any change in activities of the Fe-S proteins. Unexpectedly, the simultaneous downregulation of TbAtm and TbMdl did not result in any growth defect, nor were the Fe-S cluster protein activities altered in either the cytosolic or mitochondrial compartments. Additionally, TbAtm and TbMdl were able to partially restore the growth of the Saccharomyces cerevisiae Δatm1 and Δmdl2 null mutants, respectively. Because T. brucei completely lost the heme b biosynthesis pathway, this cofactor has to be obtained from the host. Based on our results, TbMdl is a candidate for mitochondrial import of heme b, which was markedly decreased in both TbMdl and TbAtm + TbMdl knockdowns. Moreover, the levels of heme a were strongly decreased in the same knockdowns, suggesting that TbMdl plays a key role in heme a biosynthesis, thus affecting the overall heme homeostasis in T. brucei." @default.
• W1901786564 created "2016-06-24" @default.
• W1901786564 creator A5017227781 @default.
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• W1901786564 creator A5082578042 @default.
• W1901786564 creator A5083304783 @default.
• W1901786564 creator A5086563727 @default.
• W1901786564 date "2015-09-11" @default.
• W1901786564 modified "2023-10-05" @default.
• W1901786564 title "Simultaneous depletion of Atm and Mdl rebalances cytosolic Fe-S cluster assembly but not heme import into the mitochondrion of<i>Trypanosoma brucei</i>" @default.
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• W1901786564 doi "https://doi.org/10.1111/febs.13411" @default.
• W1901786564 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26277108" @default.
• W1901786564 hasPublicationYear "2015" @default.
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