FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W190187592> ?p ?o ?g. }

• W190187592 endingPage "504" @default.
• W190187592 startingPage "3493" @default.
• W190187592 abstract "In primary Sjögren's syndrome (SS), ocular surface changes within the conjunctival epithelium include lymphocytic infiltration, squamous cell metaplasia, and a reduction in goblet cell number. These changes may be the simple result of increased mechanical abrasion secondary to dryness. Alternatively, they may represent a local response to ocular and/or systemic inflammatory processes, perhaps in response to Epstein-Barr viral (EBV) infection, an agent recently implicated in the etiology of SS. To determine whether inflammatory processes or local infection by EBV contribute to the ocular surface pathology of SS, we examined the expression of inflammatory cell surface markers, cytokines, and EBV gene products within the ocular conjunctiva of patients with SS.Ocular conjunctival tissue was isolated from patients with primary SS and nondry eye control patients by impression cytology or direct biopsy. These specimens were examined by immunofluorescence microscopy and reverse-transcriptase polymerase chain reaction (RT-PCR) for the expression of various markers.The authors found the frequency of expression of HLA-DR (P < 0.0001), ICAM-1 (P < 0.035), and IL-6 (P < 0.0001) to be significantly elevated in patients with primary SS versus nondry eye control patients. The IL-2 receptor and cytokines IL-1 beta and IL-8 were each found to be expressed with relatively high frequency in both patient populations, whereas mRNAs encoding cytokines IL-2, IFN-gamma, GM-CSF, and TGF-beta were not reproducibly detectable in either population. Messenger RNA encoding a marker for passive-latent EBV infection (EBNA-1) was detected with high frequency in both SS and normal populations. The EBV IL-10 analog BCRF-1 was expressed with low frequency in the SS population; however, these levels were not significantly different from the control population. The expression of two other markers of EBV infection, latent membrane protein (LMP, a lytic and latent marker), and BZLF-1 (putative latent-lytic switch gene) was undetectable in either study population.Based on the increased expression of the cell surface molecules HLA-DR and ICAM-1, and the inflammatory cytokine IL-6, the authors propose that local inflammatory processes contribute to the ocular surface changes and ocular surface dryness associated with primary SS." @default.
• W190187592 created "2016-06-24" @default.
• W190187592 creator A5002575486 @default.
• W190187592 creator A5016219207 @default.
• W190187592 creator A5020560476 @default.
• W190187592 creator A5068654082 @default.
• W190187592 creator A5086607086 @default.
• W190187592 date "1994-08-01" @default.
• W190187592 modified "2023-10-06" @default.
• W190187592 title "Sjögren's syndrome: cytokine and Epstein-Barr viral gene expression within the conjunctival epithelium." @default.
• W190187592 cites W1483610546 @default.
• W190187592 cites W1485805395 @default.
• W190187592 cites W1495698241 @default.
• W190187592 cites W172093145 @default.
• W190187592 cites W173363971 @default.
• W190187592 cites W179818011 @default.
• W190187592 cites W1814273895 @default.
• W190187592 cites W1974486772 @default.
• W190187592 cites W1978346776 @default.
• W190187592 cites W1979877257 @default.
• W190187592 cites W1980464074 @default.
• W190187592 cites W1987461148 @default.
• W190187592 cites W1989001888 @default.
• W190187592 cites W1995500533 @default.
• W190187592 cites W1998145026 @default.
• W190187592 cites W1999380065 @default.
• W190187592 cites W1999632587 @default.
• W190187592 cites W2002076761 @default.
• W190187592 cites W2007027096 @default.
• W190187592 cites W2010999269 @default.
• W190187592 cites W2011932087 @default.
• W190187592 cites W2019744876 @default.
• W190187592 cites W2022025840 @default.
• W190187592 cites W2022483849 @default.
• W190187592 cites W2024136287 @default.
• W190187592 cites W2029786286 @default.
• W190187592 cites W2030816275 @default.
• W190187592 cites W2032941398 @default.
• W190187592 cites W2037907738 @default.
• W190187592 cites W2051349203 @default.
• W190187592 cites W2051636382 @default.
• W190187592 cites W2052525810 @default.
• W190187592 cites W2073777388 @default.
• W190187592 cites W2083430194 @default.
• W190187592 cites W2100916300 @default.
• W190187592 cites W2109119643 @default.
• W190187592 cites W2112944055 @default.
• W190187592 cites W2117420131 @default.
• W190187592 cites W2126857147 @default.
• W190187592 cites W2134812217 @default.
• W190187592 cites W2154377931 @default.
• W190187592 cites W2160392761 @default.
• W190187592 cites W2170300791 @default.
• W190187592 cites W75430636 @default.
• W190187592 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8056525" @default.
• W190187592 hasPublicationYear "1994" @default.
• W190187592 type Work @default.
• W190187592 sameAs 190187592 @default.
• W190187592 citedByCount "80" @default.
• W190187592 countsByYear W1901875922012 @default.
• W190187592 countsByYear W1901875922014 @default.
• W190187592 countsByYear W1901875922015 @default.
• W190187592 countsByYear W1901875922016 @default.
• W190187592 countsByYear W1901875922017 @default.
• W190187592 countsByYear W1901875922018 @default.
• W190187592 countsByYear W1901875922019 @default.
• W190187592 countsByYear W1901875922020 @default.
• W190187592 countsByYear W1901875922022 @default.
• W190187592 countsByYear W1901875922023 @default.
• W190187592 crossrefType "journal-article" @default.
• W190187592 hasAuthorship W190187592A5002575486 @default.
• W190187592 hasAuthorship W190187592A5016219207 @default.
• W190187592 hasAuthorship W190187592A5020560476 @default.
• W190187592 hasAuthorship W190187592A5068654082 @default.
• W190187592 hasAuthorship W190187592A5086607086 @default.
• W190187592 hasConcept C142724271 @default.
• W190187592 hasConcept C203014093 @default.
• W190187592 hasConcept C2775984611 @default.
• W190187592 hasConcept C2778690821 @default.
• W190187592 hasConcept C2778981785 @default.
• W190187592 hasConcept C2908647359 @default.
• W190187592 hasConcept C529295009 @default.
• W190187592 hasConcept C71924100 @default.
• W190187592 hasConcept C86803240 @default.
• W190187592 hasConcept C99454951 @default.
• W190187592 hasConceptScore W190187592C142724271 @default.
• W190187592 hasConceptScore W190187592C203014093 @default.
• W190187592 hasConceptScore W190187592C2775984611 @default.
• W190187592 hasConceptScore W190187592C2778690821 @default.
• W190187592 hasConceptScore W190187592C2778981785 @default.
• W190187592 hasConceptScore W190187592C2908647359 @default.
• W190187592 hasConceptScore W190187592C529295009 @default.
• W190187592 hasConceptScore W190187592C71924100 @default.
• W190187592 hasConceptScore W190187592C86803240 @default.
• W190187592 hasConceptScore W190187592C99454951 @default.
• W190187592 hasIssue "9" @default.
• W190187592 hasLocation W1901875921 @default.
• W190187592 hasOpenAccess W190187592 @default.

• next