FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1902045863> ?p ?o ?g. }

• W1902045863 endingPage "7859" @default.
• W1902045863 startingPage "7847" @default.
• W1902045863 abstract "Despite the use of multimodal treatments incorporating surgery, chemotherapy and radiotherapy, local control of gliomas remains a major challenge. The potential of a new treatment approach called indirect radio-chemo-beta therapy using the synergy created by combining methotrexate (MTX) with bromodeoxyuridine (BrUdR) under optimum energy x-ray irradiation is assessed. 9L rat gliosarcoma cells pre-treated with 0.01 μM MTX and/or 10 μM BrUdR were irradiated in vitro with 50 kVp, 125 kVp, 250 kVp, 6 MV and 10 MV x-rays. The cytotoxicity was assessed using clonogenic survival as the radiobiological endpoint. The photon energy with maximum effect was determined using radiation sensitization enhancement factors at 10% clonogenic survival (SER10%). The cell cycle distribution was investigated using flow cytometric analysis with propidium iodide staining. Incorporation of BrUdR in the DNA was detected by the fluorescence of labelled anti-BrUdR antibodies. The radiation sensitization enhancement exhibits energy dependence with a maximum of 2.3 at 125 kVp for the combined drug treated cells. At this energy, the shape of the clonogenic survival curve of the pharmacological agents treated cells changes substantially. This change is interpreted as an increased lethality of the local radiation environment and is attributed to supplemented inhibition of DNA repair. Radiation induced chemo-beta therapy was demonstrated in vitro by the targeted activation of combined pharmacological agents with optimized energy tuning of x-ray beams on 9 L cells. Our results show that this is a highly effective form of chemo-radiation therapy." @default.
• W1902045863 created "2016-06-24" @default.
• W1902045863 creator A5005928966 @default.
• W1902045863 creator A5009850324 @default.
• W1902045863 creator A5017208832 @default.
• W1902045863 creator A5049676300 @default.
• W1902045863 creator A5064266739 @default.
• W1902045863 creator A5088402277 @default.
• W1902045863 date "2015-09-25" @default.
• W1902045863 modified "2023-09-26" @default.
• W1902045863 title "Indirect radio-chemo-beta therapy: a targeted approach to increase biological efficiency of x-rays based on energy" @default.
• W1902045863 cites W1742102714 @default.
• W1902045863 cites W1974997501 @default.
• W1902045863 cites W1980524534 @default.
• W1902045863 cites W1983756776 @default.
• W1902045863 cites W1986854620 @default.
• W1902045863 cites W2023676537 @default.
• W1902045863 cites W2036302880 @default.
• W1902045863 cites W2039421572 @default.
• W1902045863 cites W2040178724 @default.
• W1902045863 cites W2047670767 @default.
• W1902045863 cites W2049423881 @default.
• W1902045863 cites W2051202148 @default.
• W1902045863 cites W2062007210 @default.
• W1902045863 cites W2064110215 @default.
• W1902045863 cites W2073315333 @default.
• W1902045863 cites W2074951103 @default.
• W1902045863 cites W2078898216 @default.
• W1902045863 cites W2081566809 @default.
• W1902045863 cites W2081882275 @default.
• W1902045863 cites W2087395896 @default.
• W1902045863 cites W2088003991 @default.
• W1902045863 cites W2094013932 @default.
• W1902045863 cites W2101421459 @default.
• W1902045863 cites W2107423957 @default.
• W1902045863 cites W2107731988 @default.
• W1902045863 cites W2109126550 @default.
• W1902045863 cites W2113315101 @default.
• W1902045863 cites W2118037081 @default.
• W1902045863 cites W2137169296 @default.
• W1902045863 cites W2137374204 @default.
• W1902045863 cites W2142617635 @default.
• W1902045863 cites W2158681922 @default.
• W1902045863 cites W2161684158 @default.
• W1902045863 cites W2331509722 @default.
• W1902045863 cites W4244344354 @default.
• W1902045863 doi "https://doi.org/10.1088/0031-9155/60/20/7847" @default.
• W1902045863 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26406535" @default.
• W1902045863 hasPublicationYear "2015" @default.
• W1902045863 type Work @default.
• W1902045863 sameAs 1902045863 @default.
• W1902045863 citedByCount "4" @default.
• W1902045863 countsByYear W19020458632017 @default.
• W1902045863 countsByYear W19020458632018 @default.
• W1902045863 countsByYear W19020458632020 @default.
• W1902045863 crossrefType "journal-article" @default.
• W1902045863 hasAuthorship W1902045863A5005928966 @default.
• W1902045863 hasAuthorship W1902045863A5009850324 @default.
• W1902045863 hasAuthorship W1902045863A5017208832 @default.
• W1902045863 hasAuthorship W1902045863A5049676300 @default.
• W1902045863 hasAuthorship W1902045863A5064266739 @default.
• W1902045863 hasAuthorship W1902045863A5088402277 @default.
• W1902045863 hasBestOaLocation W19020458632 @default.
• W1902045863 hasConcept C111337013 @default.
• W1902045863 hasConcept C117262875 @default.
• W1902045863 hasConcept C11928243 @default.
• W1902045863 hasConcept C121332964 @default.
• W1902045863 hasConcept C121608353 @default.
• W1902045863 hasConcept C126322002 @default.
• W1902045863 hasConcept C185544564 @default.
• W1902045863 hasConcept C185592680 @default.
• W1902045863 hasConcept C190283241 @default.
• W1902045863 hasConcept C192562407 @default.
• W1902045863 hasConcept C202751555 @default.
• W1902045863 hasConcept C203014093 @default.
• W1902045863 hasConcept C2775934118 @default.
• W1902045863 hasConcept C2776217527 @default.
• W1902045863 hasConcept C2776428644 @default.
• W1902045863 hasConcept C29537977 @default.
• W1902045863 hasConcept C2989005 @default.
• W1902045863 hasConcept C31573885 @default.
• W1902045863 hasConcept C502942594 @default.
• W1902045863 hasConcept C509974204 @default.
• W1902045863 hasConcept C553184892 @default.
• W1902045863 hasConcept C55493867 @default.
• W1902045863 hasConcept C71924100 @default.
• W1902045863 hasConceptScore W1902045863C111337013 @default.
• W1902045863 hasConceptScore W1902045863C117262875 @default.
• W1902045863 hasConceptScore W1902045863C11928243 @default.
• W1902045863 hasConceptScore W1902045863C121332964 @default.
• W1902045863 hasConceptScore W1902045863C121608353 @default.
• W1902045863 hasConceptScore W1902045863C126322002 @default.
• W1902045863 hasConceptScore W1902045863C185544564 @default.
• W1902045863 hasConceptScore W1902045863C185592680 @default.
• W1902045863 hasConceptScore W1902045863C190283241 @default.
• W1902045863 hasConceptScore W1902045863C192562407 @default.
• W1902045863 hasConceptScore W1902045863C202751555 @default.
• W1902045863 hasConceptScore W1902045863C203014093 @default.

• next