FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1902133904> ?p ?o ?g. }

• W1902133904 endingPage "467" @default.
• W1902133904 startingPage "459" @default.
• W1902133904 abstract "The growth hormone receptor knockout (GHRKO) mice are remarkably long‐lived and highly insulin sensitive. Alterations in mitochondrial biogenesis are associated with aging and various metabolic derangements. We have previously demonstrated increased gene expression of key regulators of mitochondriogenesis in kidneys, hearts and skeletal muscles of GHRKO mice. The aim of the present study was to quantify the protein levels of the following regulators of mitochondriogenesis: peroxisome proliferator‐activated receptor γ co‐activator 1 α (PGC‐1 α ), AMP‐activated protein kinase α (AMPK α ), phospho‐AMPK α (p‐AMPK α ), sirtuin‐3 (SIRT‐3), endothelial nitric oxide synthase (eNOS), phospho‐eNOS (p‐eNOS), nuclear respiratory factor‐1 (NRF‐1) and mitofusin‐2 (MFN‐2) in skeletal muscles and kidneys of GHRKOs in comparison to normal mice. We also were interested in the effects of calorie restriction (CR) and visceral fat removal (VFR) on these parameters. Both CR and VFR improve insulin sensitivity and can extend life span. Results: The renal levels of PGC‐1 α , AMPK α , p‐AMPK α , SIRT‐3, eNOS, p‐eNOS and MFN‐2 were increased in GHRKOs. In the GHRKO skeletal muscles, only MFN‐2 was increased. Levels of the examined proteins were not affected by CR (except for PGC‐1 α and p‐eNOS in skeletal muscles) or VFR. Conclusion: GHRKO mice have increased renal protein levels of key regulators of mitochondriogenesis, and this may contribute to increased longevity of these knockouts. Copyright © 2011 John Wiley & Sons, Ltd." @default.
• W1902133904 created "2016-06-24" @default.
• W1902133904 creator A5018886262 @default.
• W1902133904 creator A5048119650 @default.
• W1902133904 creator A5053137432 @default.
• W1902133904 creator A5070670179 @default.
• W1902133904 creator A5085220923 @default.
• W1902133904 date "2011-07-14" @default.
• W1902133904 modified "2023-09-27" @default.
• W1902133904 title "Key regulators of mitochondrial biogenesis are increased in kidneys of growth hormone receptor knockout (GHRKO) mice" @default.
• W1902133904 cites W1762535185 @default.
• W1902133904 cites W1928175618 @default.
• W1902133904 cites W1964598964 @default.
• W1902133904 cites W1971082641 @default.
• W1902133904 cites W1984397718 @default.
• W1902133904 cites W1985834536 @default.
• W1902133904 cites W1987845572 @default.
• W1902133904 cites W1989759127 @default.
• W1902133904 cites W2000099678 @default.
• W1902133904 cites W2000301075 @default.
• W1902133904 cites W2003099132 @default.
• W1902133904 cites W2007256995 @default.
• W1902133904 cites W2008632158 @default.
• W1902133904 cites W2013937244 @default.
• W1902133904 cites W2026340099 @default.
• W1902133904 cites W2034661709 @default.
• W1902133904 cites W2035545667 @default.
• W1902133904 cites W2044782567 @default.
• W1902133904 cites W2045619262 @default.
• W1902133904 cites W2049538444 @default.
• W1902133904 cites W2062748949 @default.
• W1902133904 cites W2066317254 @default.
• W1902133904 cites W2073095545 @default.
• W1902133904 cites W2074545234 @default.
• W1902133904 cites W2077645437 @default.
• W1902133904 cites W2082625749 @default.
• W1902133904 cites W2092756896 @default.
• W1902133904 cites W2099547258 @default.
• W1902133904 cites W2100543510 @default.
• W1902133904 cites W2103416697 @default.
• W1902133904 cites W2105276425 @default.
• W1902133904 cites W2107914241 @default.
• W1902133904 cites W2109693559 @default.
• W1902133904 cites W2109879006 @default.
• W1902133904 cites W2115204044 @default.
• W1902133904 cites W2125221913 @default.
• W1902133904 cites W2127806759 @default.
• W1902133904 cites W2128557475 @default.
• W1902133904 cites W2130617666 @default.
• W1902133904 cites W2140751228 @default.
• W1902133904 cites W2141789735 @default.
• W1902133904 cites W2147253226 @default.
• W1902133904 cites W2149249593 @default.
• W1902133904 cites W2151427219 @default.
• W1902133904 cites W2151566575 @default.
• W1902133904 cites W2151698573 @default.
• W1902133904 cites W2151993359 @default.
• W1902133904 cites W2152185756 @default.
• W1902133904 cites W2161680769 @default.
• W1902133904 cites W2162306102 @default.
• W1902133904 cites W2168136518 @default.
• W1902133904 cites W2169001678 @default.
• W1902133904 cites W2340324006 @default.
• W1902133904 cites W95405264 @default.
• W1902133904 doi "https://doi.org/10.1002/cbf.1773" @default.
• W1902133904 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3682479" @default.
• W1902133904 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21755522" @default.
• W1902133904 hasPublicationYear "2011" @default.
• W1902133904 type Work @default.
• W1902133904 sameAs 1902133904 @default.
• W1902133904 citedByCount "15" @default.
• W1902133904 countsByYear W19021339042012 @default.
• W1902133904 countsByYear W19021339042014 @default.
• W1902133904 countsByYear W19021339042015 @default.
• W1902133904 countsByYear W19021339042016 @default.
• W1902133904 countsByYear W19021339042017 @default.
• W1902133904 countsByYear W19021339042018 @default.
• W1902133904 countsByYear W19021339042019 @default.
• W1902133904 countsByYear W19021339042021 @default.
• W1902133904 countsByYear W19021339042022 @default.
• W1902133904 crossrefType "journal-article" @default.
• W1902133904 hasAuthorship W1902133904A5018886262 @default.
• W1902133904 hasAuthorship W1902133904A5048119650 @default.
• W1902133904 hasAuthorship W1902133904A5053137432 @default.
• W1902133904 hasAuthorship W1902133904A5070670179 @default.
• W1902133904 hasAuthorship W1902133904A5085220923 @default.
• W1902133904 hasBestOaLocation W19021339042 @default.
• W1902133904 hasConcept C126322002 @default.
• W1902133904 hasConcept C134018914 @default.
• W1902133904 hasConcept C170493617 @default.
• W1902133904 hasConcept C182704531 @default.
• W1902133904 hasConcept C184235292 @default.
• W1902133904 hasConcept C187345961 @default.
• W1902133904 hasConcept C2776780712 @default.
• W1902133904 hasConcept C2777229759 @default.
• W1902133904 hasConcept C2777622882 @default.
• W1902133904 hasConcept C2778326061 @default.
• W1902133904 hasConcept C2780091579 @default.

• next