FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1902156758> ?p ?o ?g. }

• W1902156758 endingPage "1813" @default.
• W1902156758 startingPage "1803" @default.
• W1902156758 abstract "Women diagnosed with breast cancer within 5 years postpartum have poor survival rates. The process of postpartum mammary gland involution, whereby the lactating gland remodels to its prepregnant state, promotes breast cancer progression in xenograft models. Macrophage influx occurs during mammary gland involution, implicating immune modulation in the promotion of postpartum breast cancer. Herein, we characterize the postpartum murine mammary gland and find an orchestrated influx of immune cells similar to that which occurs during wound healing. Further, the normal involuting gland may be in an immunosuppressed state as discerned by the transient presence of Foxp3+ regulatory T cells and IL-10+ macrophages with T cell suppressive function. To determine the influence of the postpartum immune microenvironment on mammary tumor promotion, we developed an immune-competent model. In this model, mammary tumors in the involution group are sixfold larger than nulliparous group tumors, have decreased CD4+ and CD8+ T cell infiltrates and contain a greater number of macrophages with the ability to inhibit T cell activation. Targeting involution with a neutralizing antibody against the immunosuppressive cytokine IL-10 reduces tumor growth in involution group mice but not in nulliparous mice, implicating the involution microenvironment as the primary target of αIL-10 treatment. Relevance to women is implicated, as we find postlactational human breast tissue has transient high IL-10+ and Foxp3+ immune cell infiltrate. These data show an immune modulated microenvironment within the normal involuting mammary gland suggestive of immunosuppression, that when targeted reduces tumor promotion, revealing possible immune-based strategies for postpartum breast cancer." @default.
• W1902156758 created "2016-06-24" @default.
• W1902156758 creator A5001562050 @default.
• W1902156758 creator A5009265160 @default.
• W1902156758 creator A5035268663 @default.
• W1902156758 creator A5056577711 @default.
• W1902156758 creator A5068993156 @default.
• W1902156758 date "2014-09-15" @default.
• W1902156758 modified "2023-10-11" @default.
• W1902156758 title "Wound healing‐like immune program facilitates postpartum mammary gland involution and tumor progression" @default.
• W1902156758 cites W1573103899 @default.
• W1902156758 cites W1828930947 @default.
• W1902156758 cites W1834589661 @default.
• W1902156758 cites W1909391377 @default.
• W1902156758 cites W1975011653 @default.
• W1902156758 cites W1980015273 @default.
• W1902156758 cites W1990133575 @default.
• W1902156758 cites W1992282855 @default.
• W1902156758 cites W1992444004 @default.
• W1902156758 cites W1995232616 @default.
• W1902156758 cites W2004536682 @default.
• W1902156758 cites W2009134006 @default.
• W1902156758 cites W2015141049 @default.
• W1902156758 cites W2032730667 @default.
• W1902156758 cites W2038239984 @default.
• W1902156758 cites W2041591721 @default.
• W1902156758 cites W2043522520 @default.
• W1902156758 cites W2057092744 @default.
• W1902156758 cites W2058648826 @default.
• W1902156758 cites W2060530444 @default.
• W1902156758 cites W2060672294 @default.
• W1902156758 cites W2065769697 @default.
• W1902156758 cites W2081432712 @default.
• W1902156758 cites W2085099489 @default.
• W1902156758 cites W2085753760 @default.
• W1902156758 cites W2088954638 @default.
• W1902156758 cites W2090203203 @default.
• W1902156758 cites W2093283052 @default.
• W1902156758 cites W2093705034 @default.
• W1902156758 cites W2093758411 @default.
• W1902156758 cites W2095537212 @default.
• W1902156758 cites W2096637314 @default.
• W1902156758 cites W2098032421 @default.
• W1902156758 cites W2099887788 @default.
• W1902156758 cites W2101791298 @default.
• W1902156758 cites W2112793131 @default.
• W1902156758 cites W2113687012 @default.
• W1902156758 cites W2117051514 @default.
• W1902156758 cites W2122403898 @default.
• W1902156758 cites W2130293973 @default.
• W1902156758 cites W2131464730 @default.
• W1902156758 cites W2134658635 @default.
• W1902156758 cites W2146708145 @default.
• W1902156758 cites W2149142217 @default.
• W1902156758 cites W2152310279 @default.
• W1902156758 cites W2153363408 @default.
• W1902156758 cites W2157269800 @default.
• W1902156758 cites W2157962067 @default.
• W1902156758 cites W2163035374 @default.
• W1902156758 cites W2314203153 @default.
• W1902156758 doi "https://doi.org/10.1002/ijc.29181" @default.
• W1902156758 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4324053" @default.
• W1902156758 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25187059" @default.
• W1902156758 hasPublicationYear "2014" @default.
• W1902156758 type Work @default.
• W1902156758 sameAs 1902156758 @default.
• W1902156758 citedByCount "110" @default.
• W1902156758 countsByYear W19021567582015 @default.
• W1902156758 countsByYear W19021567582016 @default.
• W1902156758 countsByYear W19021567582017 @default.
• W1902156758 countsByYear W19021567582018 @default.
• W1902156758 countsByYear W19021567582019 @default.
• W1902156758 countsByYear W19021567582020 @default.
• W1902156758 countsByYear W19021567582021 @default.
• W1902156758 countsByYear W19021567582022 @default.
• W1902156758 countsByYear W19021567582023 @default.
• W1902156758 crossrefType "journal-article" @default.
• W1902156758 hasAuthorship W1902156758A5001562050 @default.
• W1902156758 hasAuthorship W1902156758A5009265160 @default.
• W1902156758 hasAuthorship W1902156758A5035268663 @default.
• W1902156758 hasAuthorship W1902156758A5056577711 @default.
• W1902156758 hasAuthorship W1902156758A5068993156 @default.
• W1902156758 hasBestOaLocation W19021567581 @default.
• W1902156758 hasConcept C121608353 @default.
• W1902156758 hasConcept C126322002 @default.
• W1902156758 hasConcept C134018914 @default.
• W1902156758 hasConcept C167672396 @default.
• W1902156758 hasConcept C169760540 @default.
• W1902156758 hasConcept C186720457 @default.
• W1902156758 hasConcept C203014093 @default.
• W1902156758 hasConcept C2776107976 @default.
• W1902156758 hasConcept C2776187077 @default.
• W1902156758 hasConcept C2778001805 @default.
• W1902156758 hasConcept C2778690821 @default.
• W1902156758 hasConcept C2779727006 @default.
• W1902156758 hasConcept C2781409172 @default.
• W1902156758 hasConcept C502942594 @default.
• W1902156758 hasConcept C530470458 @default.

• next