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• W1902164637 abstract "The aim of this study was to determine if a three-day treatment of lower urinary tract infection (UTI) is effective. 215 women with symptoms of lower UTI, seen in general practice, were randomly allocated to a double-blind study and given either amoxycillin 1000 mg twice a day for three days or trimethoprim 90 mg/sulphadiazine 410 mg (co-trimazine) 2 tablets initially, then one tablet twice daily for three days. 157 women (73%) had significant bacteriuria. Therapeutic efficacy was evaluated in 146 patients. One week after treatment had started, 88 % of the women in the amoxycillin group and 100% in the co-trimazine group were cured (p<0.01). After a follow-up period of four weeks, the cumulative relapse frequencies were 19% and 9% respectively. Adverse reactions were mild in most cases. Two patients, both on co-trimazine, had to discontinue treatment because of nausea and vomiting. Vulvovaginal irritation was more often reported by women treated with amoxycillin (n=8) than by those treated with co-trimazine (n = 1) (p<0.05). It is concluded that a three-day course of amoxycillin or co-trimazine in lower UTI is safe, causes few adverse reactions, is simple to administer and comfortable for the patient. Co-trimazine seems to be more effective than amoxycillin." @default.
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• W1902164637 date "2009-04-24" @default.
• W1902164637 modified "2023-10-16" @default.
• W1902164637 title "Three-Day Treatment of Acute Lower Urinary Tract Infections in Women" @default.
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• W1902164637 doi "https://doi.org/10.1111/j.0954-6820.1983.tb03690.x" @default.
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