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- W1902487713 abstract "AbstractKinase inhibitors have emerged as effective cancer therapeutics in a variety of human cancers. Glioblastoma (GBM), the most common malignant brain tumor in adults, represents a compelling disease for kinase inhibitor therapy because the majority of these tumors harbor genetic alterations that result in aberrant activation of growth factor signaling pathways. Attempts to target the Ras—Phosphatidylinositol 3-kinase (PI3K)—mammalian Target of Rapamycin (mTOR) axis in GBM with first generation receptor tyrosine kinase (RTK) inhibitors and rapalogs have been disappointing. However, there is reason for renewed optimism given the now very detailed knowledge of the cancer genome in GBM and a wealth of novel compounds entering the clinic, including next generation RTK inhibitors, class I PI3K inhibitors, mTOR kinase inhibitors (TORKinibs), and dual PI3(K)/mTOR inhibitors. This chapter reviews common genetic alterations in growth factor signaling pathways in GBM, their validation as therapeutic targets in this disease, and strategies for future clinical development of kinase inhibitors for high grade glioma.KeywordsEpidermal Growth Factor ReceptorHigh Grade GliomaPIK3CA MutationEpidermal Growth Factor Receptor GeneReceptor Tyrosine Kinase InhibitorThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves." @default.
- W1902487713 created "2016-06-24" @default.
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- W1902487713 creator A5033125884 @default.
- W1902487713 creator A5042065032 @default.
- W1902487713 creator A5063511816 @default.
- W1902487713 date "2011-01-01" @default.
- W1902487713 modified "2023-10-03" @default.
- W1902487713 title "Will Kinase Inhibitors Make it as Glioblastoma Drugs?" @default.
- W1902487713 cites W1488234136 @default.
- W1902487713 cites W1489057868 @default.
- W1902487713 cites W1495551511 @default.
- W1902487713 cites W1508849983 @default.
- W1902487713 cites W1557061959 @default.
- W1902487713 cites W1557470610 @default.
- W1902487713 cites W1594020010 @default.
- W1902487713 cites W1639582946 @default.
- W1902487713 cites W1964130185 @default.
- W1902487713 cites W1966803171 @default.
- W1902487713 cites W1969292035 @default.
- W1902487713 cites W1971119203 @default.
- W1902487713 cites W1971267920 @default.
- W1902487713 cites W1971525986 @default.
- W1902487713 cites W1972960760 @default.
- W1902487713 cites W1973071934 @default.
- W1902487713 cites W1975381965 @default.
- W1902487713 cites W1978916359 @default.
- W1902487713 cites W1983033726 @default.
- W1902487713 cites W1983493537 @default.
- W1902487713 cites W1988036808 @default.
- W1902487713 cites W1988609792 @default.
- W1902487713 cites W1994379208 @default.
- W1902487713 cites W1995725988 @default.
- W1902487713 cites W1998203489 @default.
- W1902487713 cites W1998309952 @default.
- W1902487713 cites W1998836974 @default.
- W1902487713 cites W1999851814 @default.
- W1902487713 cites W1999969244 @default.
- W1902487713 cites W2000110198 @default.
- W1902487713 cites W2001231863 @default.
- W1902487713 cites W2003506162 @default.
- W1902487713 cites W2004691500 @default.
- W1902487713 cites W2006979538 @default.
- W1902487713 cites W2007920048 @default.
- W1902487713 cites W2008345619 @default.
- W1902487713 cites W2010677999 @default.
- W1902487713 cites W2012306540 @default.
- W1902487713 cites W2012346684 @default.
- W1902487713 cites W2013138515 @default.
- W1902487713 cites W2013878898 @default.
- W1902487713 cites W2014006702 @default.
- W1902487713 cites W2014250484 @default.
- W1902487713 cites W2014652769 @default.
- W1902487713 cites W2015173256 @default.
- W1902487713 cites W2017090190 @default.
- W1902487713 cites W2017289276 @default.
- W1902487713 cites W2018671779 @default.
- W1902487713 cites W2019349725 @default.
- W1902487713 cites W2020372547 @default.
- W1902487713 cites W2024676945 @default.
- W1902487713 cites W2024791894 @default.
- W1902487713 cites W2024883604 @default.
- W1902487713 cites W2025183726 @default.
- W1902487713 cites W2025238642 @default.
- W1902487713 cites W2027625542 @default.
- W1902487713 cites W2028415754 @default.
- W1902487713 cites W2029722899 @default.
- W1902487713 cites W2035033765 @default.
- W1902487713 cites W2036450767 @default.
- W1902487713 cites W2037044453 @default.
- W1902487713 cites W2038305873 @default.
- W1902487713 cites W2039382551 @default.
- W1902487713 cites W2039628288 @default.
- W1902487713 cites W2040827479 @default.
- W1902487713 cites W2044351212 @default.
- W1902487713 cites W2046289188 @default.
- W1902487713 cites W2047401805 @default.
- W1902487713 cites W2049884365 @default.
- W1902487713 cites W2050601632 @default.
- W1902487713 cites W2052588647 @default.
- W1902487713 cites W2053655323 @default.
- W1902487713 cites W2054455334 @default.
- W1902487713 cites W2054958296 @default.
- W1902487713 cites W2055107833 @default.
- W1902487713 cites W2055560959 @default.
- W1902487713 cites W2057370954 @default.
- W1902487713 cites W2060146306 @default.
- W1902487713 cites W2061288640 @default.
- W1902487713 cites W2061491996 @default.
- W1902487713 cites W2061671663 @default.
- W1902487713 cites W2062809578 @default.
- W1902487713 cites W2067040565 @default.
- W1902487713 cites W2068345721 @default.
- W1902487713 cites W2070705072 @default.
- W1902487713 cites W2074153710 @default.
- W1902487713 cites W2074591493 @default.
- W1902487713 cites W2076118871 @default.
- W1902487713 cites W2077582389 @default.