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- W1902591710 abstract "Mutations in the E3 ubiquitin ligase Parkin have been linked to familial Parkinson's disease. Parkin has also been implicated in mitosis through mechanisms that are unclear. Here we show that Parkin interacts with anaphase promoting complex/cyclosome (APC/C) coactivators Cdc20 and Cdh1 to mediate the degradation of several key mitotic regulators independent of APC/C. We demonstrate that ordered progression through mitosis is orchestrated by two distinct E3 ligases through the shared use of Cdc20 and Cdh1. Furthermore, Parkin is phosphorylated and activated by polo-like kinase 1 (Plk1) during mitosis. Parkin deficiency results in overexpression of its substrates, mitotic defects, genomic instability, and tumorigenesis. These results suggest that the Parkin-Cdc20/Cdh1 complex is an important regulator of mitosis." @default.
- W1902591710 created "2016-06-24" @default.
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- W1902591710 date "2015-10-01" @default.
- W1902591710 modified "2023-10-02" @default.
- W1902591710 title "Parkin Regulates Mitosis and Genomic Stability through Cdc20/Cdh1" @default.
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- W1902591710 doi "https://doi.org/10.1016/j.molcel.2015.08.011" @default.
- W1902591710 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4592523" @default.
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