FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1902672695> ?p ?o ?g. }

• W1902672695 endingPage "e0133582" @default.
• W1902672695 startingPage "e0133582" @default.
• W1902672695 abstract "The involvement of local and systemic oxidative stress in intraocular pressure (IOP) elevation and optic nerve damage has been hypothesized in the pathogenesis of glaucoma. We reported previously that the level of systemic antioxidative capacity is lower in patients with open-angle glaucoma than controls without glaucoma. Here, we assessed the correlation between IOP and systemic levels of prooxidants and antioxidants by analyzing the blood biochemistry in patients with glaucoma.Peripheral blood samples were collected from Japanese patients with primary open-angle glaucoma (n = 206), exfoliation syndrome (n = 199), and controls (n = 126). Serum levels of lipid peroxides, ferric-reducing activity, and thiol antioxidant activity were measured by diacron reactive oxygen metabolite (dROM), biological antioxidant potential (BAP), and sulfhydryl (SH) tests, respectively, using a free radical analyzer. To test the possible effect of oxidative stress on IOP levels, the patients were classified into one of four groups (Q1, Q2, Q3, and Q4, with Q1 having the lowest IOP) based on the quartile value of IOP. For this classification, the known highest IOP value in both the right and left eyes was regarded as each subject's IOP. For comparisons among the IOP groups, the differences were calculated using one-way analysis of variance followed by post-hoc unpaired t-tests. To adjust for differences in demographic characteristic distributions, the dROM, BAP, and SH test values were compared among the IOP groups using multiple logistic regression analysis; the odds ratio (OR) of each variable was calculated with the Q1 group as the reference.The dROM and the SH levels did not differ significantly (p = 0.6704 and p = 0.6376, respectively) among the four IOP groups. The BAP levels differed significantly (p = 0.0115) among the four IOP groups; the value was significantly lower in the Q4 group (1,932 μmol/L) compared with the Q1 (2,023 μmol/L, p = 0.0042) and Q2 (2,003 μmol/L, p = 0.0302) groups and significantly lower in the Q3 group (1,948 μmol/L) than the Q1 (p = 0.0174) group. After adjustment for differences in various demographic characteristics, lower BAP values were significantly associated with the classification into higher IOP groups (Q3 group, p = 0.0261 and OR = 0.06/range; Q4 group, p = 0.0018 and OR = 0.04/range). The dROM and SH values did not reach significance in any comparisons.Lower systemic antioxidant capacity measured by ferric-reducing activity is involved in the pathogenesis of open-angle glaucoma via its roles in IOP elevation." @default.
• W1902672695 created "2016-06-24" @default.
• W1902672695 creator A5018422527 @default.
• W1902672695 creator A5042067942 @default.
• W1902672695 creator A5042536343 @default.
• W1902672695 creator A5074918314 @default.
• W1902672695 date "2015-07-17" @default.
• W1902672695 modified "2023-09-30" @default.
• W1902672695 title "Correlation between Systemic Oxidative Stress and Intraocular Pressure Level" @default.
• W1902672695 cites W143622574 @default.
• W1902672695 cites W1498809151 @default.
• W1902672695 cites W1609845886 @default.
• W1902672695 cites W1662750915 @default.
• W1902672695 cites W195116966 @default.
• W1902672695 cites W1955294074 @default.
• W1902672695 cites W1965780404 @default.
• W1902672695 cites W1969967464 @default.
• W1902672695 cites W1970453202 @default.
• W1902672695 cites W1973020985 @default.
• W1902672695 cites W1973709640 @default.
• W1902672695 cites W1977120445 @default.
• W1902672695 cites W1980578349 @default.
• W1902672695 cites W1981976464 @default.
• W1902672695 cites W1987723290 @default.
• W1902672695 cites W1991025036 @default.
• W1902672695 cites W1991332502 @default.
• W1902672695 cites W1996483574 @default.
• W1902672695 cites W2000696908 @default.
• W1902672695 cites W2002022490 @default.
• W1902672695 cites W2002022907 @default.
• W1902672695 cites W2004671404 @default.
• W1902672695 cites W2006370393 @default.
• W1902672695 cites W2013343028 @default.
• W1902672695 cites W2021933371 @default.
• W1902672695 cites W2024275748 @default.
• W1902672695 cites W2024536692 @default.
• W1902672695 cites W2029754794 @default.
• W1902672695 cites W2031376424 @default.
• W1902672695 cites W2036143021 @default.
• W1902672695 cites W2039892405 @default.
• W1902672695 cites W2047802468 @default.
• W1902672695 cites W2050438215 @default.
• W1902672695 cites W2054231953 @default.
• W1902672695 cites W2058913320 @default.
• W1902672695 cites W2060582443 @default.
• W1902672695 cites W2063576996 @default.
• W1902672695 cites W2068651555 @default.
• W1902672695 cites W2072112660 @default.
• W1902672695 cites W2073434711 @default.
• W1902672695 cites W2074834737 @default.
• W1902672695 cites W2085510239 @default.
• W1902672695 cites W2088402556 @default.
• W1902672695 cites W2088651192 @default.
• W1902672695 cites W2091936382 @default.
• W1902672695 cites W2093118313 @default.
• W1902672695 cites W2113699453 @default.
• W1902672695 cites W2134757840 @default.
• W1902672695 cites W2134783232 @default.
• W1902672695 cites W2137668170 @default.
• W1902672695 cites W2143234171 @default.
• W1902672695 cites W2148593034 @default.
• W1902672695 cites W2152147293 @default.
• W1902672695 cites W2171805689 @default.
• W1902672695 cites W2412807821 @default.
• W1902672695 cites W2460164463 @default.
• W1902672695 cites W99216986 @default.
• W1902672695 doi "https://doi.org/10.1371/journal.pone.0133582" @default.
• W1902672695 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4506090" @default.
• W1902672695 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26186651" @default.
• W1902672695 hasPublicationYear "2015" @default.
• W1902672695 type Work @default.
• W1902672695 sameAs 1902672695 @default.
• W1902672695 citedByCount "44" @default.
• W1902672695 countsByYear W19026726952016 @default.
• W1902672695 countsByYear W19026726952017 @default.
• W1902672695 countsByYear W19026726952018 @default.
• W1902672695 countsByYear W19026726952019 @default.
• W1902672695 countsByYear W19026726952020 @default.
• W1902672695 countsByYear W19026726952021 @default.
• W1902672695 countsByYear W19026726952022 @default.
• W1902672695 countsByYear W19026726952023 @default.
• W1902672695 crossrefType "journal-article" @default.
• W1902672695 hasAuthorship W1902672695A5018422527 @default.
• W1902672695 hasAuthorship W1902672695A5042067942 @default.
• W1902672695 hasAuthorship W1902672695A5042536343 @default.
• W1902672695 hasAuthorship W1902672695A5074918314 @default.
• W1902672695 hasBestOaLocation W19026726951 @default.
• W1902672695 hasConcept C118487528 @default.
• W1902672695 hasConcept C126322002 @default.
• W1902672695 hasConcept C156957248 @default.
• W1902672695 hasConcept C185592680 @default.
• W1902672695 hasConcept C2776151105 @default.
• W1902672695 hasConcept C2778004101 @default.
• W1902672695 hasConcept C2778527774 @default.
• W1902672695 hasConcept C2781092963 @default.
• W1902672695 hasConcept C2991803831 @default.
• W1902672695 hasConcept C44249647 @default.
• W1902672695 hasConcept C55493867 @default.

• next