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- W1902689735 abstract "Abstract Tritium-labeled group A streptococcal carbohydrate haptens have been prepared by incubation of acid hydrolysates of group A carbohydrate with 3H-borohydride. Isolation of hapten was achieved by column and thin layer chromatography. These procedures yielded an antigenically univalent hapten, “α hapten,” with an estimated molecular weight of 1100 daltons and a rhamnose: glucosamine molar ratio of 6:1. The α hapten inhibited the binding of A-carbohydrate with homologous antiserum. Comparative antibody-binding studies were performed with group A streptococcal rabbit antibody preparations by using the α hapten and a synthetic 3H-p-nitrophenyl-β-N-acetylglucosamine (3H-pNøNAG) hapten. These studies demonstrate that average association constants (K0) obtained with the α hapten are one to two orders of magnitude higher than the K0 determined with 3H-pNøNAG. Significantly less nonspecific binding was observed with the α hapten. Binding studies with the α hapten enabled the determination of K0 for a number of antibody preparations which failed to evidence specific binding with 3H-pNøNAG. The availability of the α hapten makes more feasible the reliable determination of K0 for antibody prepared under various conditions." @default.
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- W1902689735 date "1973-09-01" @default.
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- W1902689735 title "Characterization and Antibody-Binding Capacity of Streptococcal Group a Carbohydrate Haptens" @default.
- W1902689735 doi "https://doi.org/10.4049/jimmunol.111.3.868" @default.
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