FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1902750135> ?p ?o ?g. }

• W1902750135 endingPage "96" @default.
• W1902750135 startingPage "84" @default.
• W1902750135 abstract "Abstract: Neurodegenerative disorders and chronic disability due to stroke in the brain or spinal cord afflict a large sector of the population. To investigate the mechanism involved in ischemic stroke and to develop neuroprotective drugs/therapies, in vivo and in vitro, pharmacological models are needed. To investigate the cellular and molecular neuroprotective mechanisms of nerve growth factor (NGF), a member of the nervous system neurotrophin family of growth factors, under ischemia, we used an oxygen-glucose-deprivation (OGD) device and pheochromocytoma PC12 cells exposed to a paradigm of ischemic insult. Pretreatment of the cultures with 50 ng/mL of NGF, 18 h prior to OGD insult, conferred 30% of neuroprotection. Time-course experiments showed marked activation of the ERK, JNK, and p-38 MAPK isoforms during the OGD phase, but not during OGD reperfusion. Pretreatment of the cultures with 50 ng/mL of NGF, 18 h prior to OGD insult, resulted in 50% attenuation of OGD-induced activation of JNK 1, and 20% and 50% attenuation of OGD-induced activation of p-38 α and β, respectively. The effect of NGF on gene expression in the PC12 ischemic model using Affymatrix Rat DNA-Microarray technology indicates that only 6% of the genes are differentially regulated (induced/suppressed) by OGD insult and/or NGF. These findings support the notion that pretreatment with NGF confers neuroprotection from OGD insult, a phenomenon coincidentally related to differential inhibition of MAPK stress kinase isoforms and differential gene expression. This ischemic model may be useful to investigate molecular mechanisms of OGD-induced neurotoxicity and NGF-induced neuroprotection, and to generate novel therapeutic concepts for stroke treatment." @default.
• W1902750135 created "2016-06-24" @default.
• W1902750135 creator A5007950605 @default.
• W1902750135 creator A5049332135 @default.
• W1902750135 creator A5053182759 @default.
• W1902750135 creator A5053474076 @default.
• W1902750135 creator A5063592070 @default.
• W1902750135 creator A5072325478 @default.
• W1902750135 date "2008-06-28" @default.
• W1902750135 modified "2023-10-16" @default.
• W1902750135 title "Neuroprotection by NGF in the PC12 In Vitro OGD Model" @default.
• W1902750135 cites W117431324 @default.
• W1902750135 cites W144463400 @default.
• W1902750135 cites W1517407659 @default.
• W1902750135 cites W1603686013 @default.
• W1902750135 cites W1605936700 @default.
• W1902750135 cites W1970587959 @default.
• W1902750135 cites W1976385326 @default.
• W1902750135 cites W1983708941 @default.
• W1902750135 cites W1984715375 @default.
• W1902750135 cites W1986825817 @default.
• W1902750135 cites W1990736894 @default.
• W1902750135 cites W1991500309 @default.
• W1902750135 cites W2000780795 @default.
• W1902750135 cites W2010170013 @default.
• W1902750135 cites W2014686564 @default.
• W1902750135 cites W2015262351 @default.
• W1902750135 cites W2018013926 @default.
• W1902750135 cites W2020793101 @default.
• W1902750135 cites W2024917983 @default.
• W1902750135 cites W2028929157 @default.
• W1902750135 cites W2030348181 @default.
• W1902750135 cites W2031398528 @default.
• W1902750135 cites W2031702150 @default.
• W1902750135 cites W2032054534 @default.
• W1902750135 cites W2032466814 @default.
• W1902750135 cites W2033983053 @default.
• W1902750135 cites W2036352622 @default.
• W1902750135 cites W2038258886 @default.
• W1902750135 cites W2038551082 @default.
• W1902750135 cites W2055149392 @default.
• W1902750135 cites W2059485051 @default.
• W1902750135 cites W2061482527 @default.
• W1902750135 cites W2068814836 @default.
• W1902750135 cites W2085031640 @default.
• W1902750135 cites W2086835104 @default.
• W1902750135 cites W2091770093 @default.
• W1902750135 cites W2094556796 @default.
• W1902750135 cites W2101846365 @default.
• W1902750135 cites W2110795584 @default.
• W1902750135 cites W2113879673 @default.
• W1902750135 cites W2117219210 @default.
• W1902750135 cites W2119361990 @default.
• W1902750135 cites W2122057254 @default.
• W1902750135 cites W2133414832 @default.
• W1902750135 cites W2133966135 @default.
• W1902750135 cites W2139565721 @default.
• W1902750135 cites W2144792853 @default.
• W1902750135 cites W2144983731 @default.
• W1902750135 cites W2146441148 @default.
• W1902750135 cites W2152426226 @default.
• W1902750135 doi "https://doi.org/10.1111/j.1749-6632.2005.tb00013.x" @default.
• W1902750135 hasPublicationYear "2008" @default.
• W1902750135 type Work @default.
• W1902750135 sameAs 1902750135 @default.
• W1902750135 citedByCount "10" @default.
• W1902750135 countsByYear W19027501352013 @default.
• W1902750135 countsByYear W19027501352018 @default.
• W1902750135 countsByYear W19027501352022 @default.
• W1902750135 crossrefType "journal-article" @default.
• W1902750135 hasAuthorship W1902750135A5007950605 @default.
• W1902750135 hasAuthorship W1902750135A5049332135 @default.
• W1902750135 hasAuthorship W1902750135A5053182759 @default.
• W1902750135 hasAuthorship W1902750135A5053474076 @default.
• W1902750135 hasAuthorship W1902750135A5063592070 @default.
• W1902750135 hasAuthorship W1902750135A5072325478 @default.
• W1902750135 hasConcept C126322002 @default.
• W1902750135 hasConcept C170493617 @default.
• W1902750135 hasConcept C184235292 @default.
• W1902750135 hasConcept C25498285 @default.
• W1902750135 hasConcept C2778423431 @default.
• W1902750135 hasConcept C2779491297 @default.
• W1902750135 hasConcept C29730261 @default.
• W1902750135 hasConcept C541997718 @default.
• W1902750135 hasConcept C57074206 @default.
• W1902750135 hasConcept C71924100 @default.
• W1902750135 hasConcept C86803240 @default.
• W1902750135 hasConcept C95444343 @default.
• W1902750135 hasConcept C98274493 @default.
• W1902750135 hasConceptScore W1902750135C126322002 @default.
• W1902750135 hasConceptScore W1902750135C170493617 @default.
• W1902750135 hasConceptScore W1902750135C184235292 @default.
• W1902750135 hasConceptScore W1902750135C25498285 @default.
• W1902750135 hasConceptScore W1902750135C2778423431 @default.
• W1902750135 hasConceptScore W1902750135C2779491297 @default.
• W1902750135 hasConceptScore W1902750135C29730261 @default.
• W1902750135 hasConceptScore W1902750135C541997718 @default.
• W1902750135 hasConceptScore W1902750135C57074206 @default.

• next