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• W1902951844 abstract "Coenzyme Q 10 (CoQ 10 ) is essential for all cells, and deficiency has been implicated in cardiovascular disease. Plant phytosterols inhibit cholesterol absorption, and may thereby also reduce cardiovascular risk. This study compared the relative bioavailability of CoQ 10 solubilized in low‐dose soybean phytosterols (SterolQ 10 ) with a generic CoQ 10 solubilizate. In a randomized, cross‐over design, 36 healthy males received a single 100 mg dose of CoQ 10 , as SterolQ 10 or generic CoQ 10 , with a two‐week washout between treatments. Plasma CoQ 10 was analysed at baseline, and at 2, 4, 6, 8 and 10 h after supplement ingestion. Subjects were then administered either 100 mg/day of generic CoQ 10 or SterolQ 10 for 4 weeks. Fasting plasma CoQ 10 levels were measured at baseline and following supplementation. The two preparations were bioequivalent in regard to the area under the curve (AUC 0–10h ) and maximum increase in concentration ( C max ), with geometric mean ratios of 0.89 (CI 0.81–0.98) and 0.88 (CI 0.80–0.96), respectively. Four‐weeks of CoQ 10 resulted in a comparable twofold increase in CoQ 10 levels for both formulations ( p < 0.001), which was similar between preparations ( p = 0.74). The combined CoQ 10 and phytosterol formulation, SterolQ 10 , showed bioequivalence to the generic CoQ 10 following a single CoQ 10 dose, and demonstrated comparable bioavailability following multiple dose administration. Copyright © 2012 John Wiley & Sons, Ltd." @default.
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• W1902951844 date "2012-01-06" @default.
• W1902951844 modified "2023-10-17" @default.
• W1902951844 title "Pharmacokinetic Comparison of a Generic Coenzyme Q10 Solubilizate and a Formulation with Soybean Phytosterols" @default.
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• W1902951844 doi "https://doi.org/10.1002/ptr.3667" @default.
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