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• W19029990 abstract "Communication between cells usually accomplished by the generation of specific signals for message transmission requires the participation of integral components of the membrane. Cell membranes perform the important task of conveying the chemical message contained in the signal into the interior of the cell. The mechanism by which the cell membrane accomplishes this function in most biological systems is generally well defined. Macromolecules called receptors located on the cell surface serve to discriminate, with a very high degree of specificity and efficacy, the ligands present in the close environment surrounding the cell. The coupling of the ligand to the receptor activates an intramembrane component having the net effect of transducing the message to activate an effector system in the interior of the cell membrane generating a second messenger to amplify the initial signal culminating in the biological response typical of the ligand and the cell. Receptor–ligand interactions are complex reactions involving all the components of the membrane, namely, protein, carbohydrate, and lipid. The receptor composed of an assembly of glycoproteins is embedded in the lipid bilayer. The chapter also discusses the experimental approaches available to evaluate the role of protein glycosylation in receptor–ligand interactions and their implications for the study of the mechanism of hormone action." @default.
• W19029990 created "2016-06-24" @default.
• W19029990 creator A5040622942 @default.
• W19029990 date "1985-01-01" @default.
• W19029990 modified "2023-10-17" @default.
• W19029990 title "Protein Glycosylation and Receptor–Ligand Interactions" @default.
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• W19029990 doi "https://doi.org/10.1016/b978-0-12-185202-3.50015-9" @default.
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