Matches in SemOpenAlex for { <https://semopenalex.org/work/W1903399216> ?p ?o ?g. }
- W1903399216 endingPage "30221" @default.
- W1903399216 startingPage "30212" @default.
- W1903399216 abstract "CD200, a protein belonging to the immunoglobulin superfamily, has been associated with a poor prognosis in lymphoproliferative disorders and in acute leukemia. We studied the expression of CD200 in a series of 244 patients with diagnosis of acute myeloid leukemia (AML), to evaluate its impact on outcome and its possible association with other known prognostic factors. CD200 was found in 136/244 (56%) patients, in 41 of whom (30%) with high intensity of expression (MFI ≥ 11). CD200 was more frequent in secondary compared to de novo leukemia (p = 0.0006), in CD34 positive cases (p = 0.00001), in Bcl2 overexpressing cases (p = 0.01), in those wild-type Flt3 (p = 0.004) and with favorable or unfavorable compared to intermediate karyotype (p = 0.0003). CD200+ patients have a two-fold lower probability to attain complete remission, both in univariate (p = 0.006) and multivariate (p = 0.04) analysis. The negative impact of CD200 was found also in overall survival (p = 0.02) and was correlated with the intensity of expression of the molecule (p = 0.024). CD200 has an additive negative impact on survival in patients with unfavorable cytogenetic (p = 0.046) and in secondary leukemia (p = 0.05), and is associate with a worsening of outcome in patients with favorable biological markers, such as mutated NPM (p = 0.02), wild-type Flt3 (p = 0.034), negativity of CD34 (p = 0.03) and of CD56 (p = 0.03). In conclusion, CD200 is emerging as both a prognostic factor and a potential target of novel therapeutic approaches for AML, aiming to reverse the do not eat me signal of CD200 or to manipulate the suppressive immune microenvironment induced by CD200 binding to its receptor." @default.
- W1903399216 created "2016-06-24" @default.
- W1903399216 creator A5002237220 @default.
- W1903399216 creator A5010397935 @default.
- W1903399216 creator A5018280069 @default.
- W1903399216 creator A5020333760 @default.
- W1903399216 creator A5020457631 @default.
- W1903399216 creator A5028721494 @default.
- W1903399216 creator A5032968890 @default.
- W1903399216 creator A5037487958 @default.
- W1903399216 creator A5044096443 @default.
- W1903399216 creator A5047530816 @default.
- W1903399216 creator A5072904606 @default.
- W1903399216 creator A5086592438 @default.
- W1903399216 date "2015-08-18" @default.
- W1903399216 modified "2023-10-04" @default.
- W1903399216 title "Clinical impact of CD200 expression in patients with acute myeloid leukemia and correlation with other molecular prognostic factors" @default.
- W1903399216 cites W1534965621 @default.
- W1903399216 cites W1547504566 @default.
- W1903399216 cites W1558680281 @default.
- W1903399216 cites W1757647948 @default.
- W1903399216 cites W1963589380 @default.
- W1903399216 cites W1969448287 @default.
- W1903399216 cites W1977747092 @default.
- W1903399216 cites W1989673842 @default.
- W1903399216 cites W1990553375 @default.
- W1903399216 cites W1994502107 @default.
- W1903399216 cites W1996814190 @default.
- W1903399216 cites W2000788593 @default.
- W1903399216 cites W2004150448 @default.
- W1903399216 cites W2004902429 @default.
- W1903399216 cites W2006285478 @default.
- W1903399216 cites W2008241551 @default.
- W1903399216 cites W2011977826 @default.
- W1903399216 cites W2012604818 @default.
- W1903399216 cites W2018641619 @default.
- W1903399216 cites W2022260878 @default.
- W1903399216 cites W2022460737 @default.
- W1903399216 cites W2026273485 @default.
- W1903399216 cites W2031452237 @default.
- W1903399216 cites W2032132964 @default.
- W1903399216 cites W2035401673 @default.
- W1903399216 cites W2038929505 @default.
- W1903399216 cites W2043216151 @default.
- W1903399216 cites W2044942890 @default.
- W1903399216 cites W2051587095 @default.
- W1903399216 cites W2052690356 @default.
- W1903399216 cites W2057726523 @default.
- W1903399216 cites W2061417824 @default.
- W1903399216 cites W2062728665 @default.
- W1903399216 cites W2069491149 @default.
- W1903399216 cites W2074425311 @default.
- W1903399216 cites W2075440816 @default.
- W1903399216 cites W2076426515 @default.
- W1903399216 cites W2079068389 @default.
- W1903399216 cites W2089183003 @default.
- W1903399216 cites W2104319926 @default.
- W1903399216 cites W2111063688 @default.
- W1903399216 cites W2116858301 @default.
- W1903399216 cites W2118270328 @default.
- W1903399216 cites W2120539661 @default.
- W1903399216 cites W2127865783 @default.
- W1903399216 cites W2134528462 @default.
- W1903399216 cites W2144395887 @default.
- W1903399216 cites W2151601086 @default.
- W1903399216 cites W2154774088 @default.
- W1903399216 cites W2158448264 @default.
- W1903399216 cites W2164018844 @default.
- W1903399216 cites W2169794517 @default.
- W1903399216 cites W2316323341 @default.
- W1903399216 cites W2395701816 @default.
- W1903399216 cites W2470638255 @default.
- W1903399216 doi "https://doi.org/10.18632/oncotarget.4901" @default.
- W1903399216 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4745791" @default.
- W1903399216 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26338961" @default.
- W1903399216 hasPublicationYear "2015" @default.
- W1903399216 type Work @default.
- W1903399216 sameAs 1903399216 @default.
- W1903399216 citedByCount "31" @default.
- W1903399216 countsByYear W19033992162016 @default.
- W1903399216 countsByYear W19033992162017 @default.
- W1903399216 countsByYear W19033992162018 @default.
- W1903399216 countsByYear W19033992162019 @default.
- W1903399216 countsByYear W19033992162020 @default.
- W1903399216 countsByYear W19033992162021 @default.
- W1903399216 countsByYear W19033992162022 @default.
- W1903399216 countsByYear W19033992162023 @default.
- W1903399216 crossrefType "journal-article" @default.
- W1903399216 hasAuthorship W1903399216A5002237220 @default.
- W1903399216 hasAuthorship W1903399216A5010397935 @default.
- W1903399216 hasAuthorship W1903399216A5018280069 @default.
- W1903399216 hasAuthorship W1903399216A5020333760 @default.
- W1903399216 hasAuthorship W1903399216A5020457631 @default.
- W1903399216 hasAuthorship W1903399216A5028721494 @default.
- W1903399216 hasAuthorship W1903399216A5032968890 @default.
- W1903399216 hasAuthorship W1903399216A5037487958 @default.
- W1903399216 hasAuthorship W1903399216A5044096443 @default.
- W1903399216 hasAuthorship W1903399216A5047530816 @default.