Matches in SemOpenAlex for { <https://semopenalex.org/work/W1903681584> ?p ?o ?g. }
Showing items 1 to 87 of
87
with 100 items per page.
- W1903681584 endingPage "964" @default.
- W1903681584 startingPage "959" @default.
- W1903681584 abstract "The study was designed to determine the role of interferon (IFN)-gamma in inflammatory responses against experimentally induced pneumonia caused by Klebsiella pneumoniae. The host immunological responses in IFN-gamma gene knockout (IFN-gamma(-/-)) mice and immunocompetent control mice were compared. K. pneumoniae strain T-113 was inoculated intranasally into anaesthetised mice to induce pneumonia. Infected control mice survived significantly longer than infected IFN-gamma(-/-) mice. Viable bacterial counts in lungs and blood abruptly increased in IFN-gamma(-/-) mice; in contrast, a gradual decrease in the number of bacteria was noted in control mice. During the early stages of infection, the concentrations of interleukin (IL)-1beta and IL-6 in broncho-alveolar lavage fluid and IL-1beta in serum of IFN-gamma(-/-) mice were significantly lower than in control mice. During the late stage of infection, serum IL-6 level in IFN-gamma(-/-) mice was significantly higher than in control mice. These results suggest that the defective immunological host response, including inflammatory cytokine production caused by deficiency of IFN-gamma, is one of the mechanisms that allow the progression of pulmonary infection to systemic septicaemia." @default.
- W1903681584 created "2016-06-24" @default.
- W1903681584 creator A5003256422 @default.
- W1903681584 creator A5015238774 @default.
- W1903681584 creator A5036014408 @default.
- W1903681584 creator A5040168683 @default.
- W1903681584 creator A5056798404 @default.
- W1903681584 creator A5074919264 @default.
- W1903681584 creator A5080526180 @default.
- W1903681584 date "2001-11-01" @default.
- W1903681584 modified "2023-10-11" @default.
- W1903681584 title "Protection against pulmonary infection with Klebsiella pneumoniae in mice by interferon-γ through activation of phagocytic cells and stimulation of production of other cytokines" @default.
- W1903681584 doi "https://doi.org/10.1099/0022-1317-50-11-959" @default.
- W1903681584 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11699592" @default.
- W1903681584 hasPublicationYear "2001" @default.
- W1903681584 type Work @default.
- W1903681584 sameAs 1903681584 @default.
- W1903681584 citedByCount "36" @default.
- W1903681584 countsByYear W19036815842012 @default.
- W1903681584 countsByYear W19036815842013 @default.
- W1903681584 countsByYear W19036815842014 @default.
- W1903681584 countsByYear W19036815842015 @default.
- W1903681584 countsByYear W19036815842016 @default.
- W1903681584 countsByYear W19036815842017 @default.
- W1903681584 countsByYear W19036815842018 @default.
- W1903681584 countsByYear W19036815842019 @default.
- W1903681584 countsByYear W19036815842021 @default.
- W1903681584 countsByYear W19036815842022 @default.
- W1903681584 crossrefType "journal-article" @default.
- W1903681584 hasAuthorship W1903681584A5003256422 @default.
- W1903681584 hasAuthorship W1903681584A5015238774 @default.
- W1903681584 hasAuthorship W1903681584A5036014408 @default.
- W1903681584 hasAuthorship W1903681584A5040168683 @default.
- W1903681584 hasAuthorship W1903681584A5056798404 @default.
- W1903681584 hasAuthorship W1903681584A5074919264 @default.
- W1903681584 hasAuthorship W1903681584A5080526180 @default.
- W1903681584 hasBestOaLocation W19036815841 @default.
- W1903681584 hasConcept C104317684 @default.
- W1903681584 hasConcept C126322002 @default.
- W1903681584 hasConcept C134018914 @default.
- W1903681584 hasConcept C203014093 @default.
- W1903681584 hasConcept C24998067 @default.
- W1903681584 hasConcept C2777058267 @default.
- W1903681584 hasConcept C2777914695 @default.
- W1903681584 hasConcept C2778690821 @default.
- W1903681584 hasConcept C2780841837 @default.
- W1903681584 hasConcept C547475151 @default.
- W1903681584 hasConcept C55493867 @default.
- W1903681584 hasConcept C71924100 @default.
- W1903681584 hasConcept C86803240 @default.
- W1903681584 hasConcept C89423630 @default.
- W1903681584 hasConceptScore W1903681584C104317684 @default.
- W1903681584 hasConceptScore W1903681584C126322002 @default.
- W1903681584 hasConceptScore W1903681584C134018914 @default.
- W1903681584 hasConceptScore W1903681584C203014093 @default.
- W1903681584 hasConceptScore W1903681584C24998067 @default.
- W1903681584 hasConceptScore W1903681584C2777058267 @default.
- W1903681584 hasConceptScore W1903681584C2777914695 @default.
- W1903681584 hasConceptScore W1903681584C2778690821 @default.
- W1903681584 hasConceptScore W1903681584C2780841837 @default.
- W1903681584 hasConceptScore W1903681584C547475151 @default.
- W1903681584 hasConceptScore W1903681584C55493867 @default.
- W1903681584 hasConceptScore W1903681584C71924100 @default.
- W1903681584 hasConceptScore W1903681584C86803240 @default.
- W1903681584 hasConceptScore W1903681584C89423630 @default.
- W1903681584 hasIssue "11" @default.
- W1903681584 hasLocation W19036815841 @default.
- W1903681584 hasLocation W19036815842 @default.
- W1903681584 hasOpenAccess W1903681584 @default.
- W1903681584 hasPrimaryLocation W19036815841 @default.
- W1903681584 hasRelatedWork W2043507772 @default.
- W1903681584 hasRelatedWork W2127265247 @default.
- W1903681584 hasRelatedWork W2352241648 @default.
- W1903681584 hasRelatedWork W2368998077 @default.
- W1903681584 hasRelatedWork W2387486394 @default.
- W1903681584 hasRelatedWork W2418637179 @default.
- W1903681584 hasRelatedWork W2782250776 @default.
- W1903681584 hasRelatedWork W2931297918 @default.
- W1903681584 hasRelatedWork W3029946593 @default.
- W1903681584 hasRelatedWork W3062875243 @default.
- W1903681584 hasVolume "50" @default.
- W1903681584 isParatext "false" @default.
- W1903681584 isRetracted "false" @default.
- W1903681584 magId "1903681584" @default.
- W1903681584 workType "article" @default.